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Fenbendazole treatment of pregnant bitches to reduce prenatal and lactogenic infections of Toxocara canis and Ancylostoma caninum in pups.
J Am Vet Med Assoc. 1983 Nov 01; 183(9):987-90.JA

Abstract

A granulated formulation of fenbendazole was tested in a total of 23 treated and control, pregnant, parasite-free Beagle bitches experimentally infected with Toxocara canis and Ancylostoma caninum. The drug was administered to each treated bitch once daily in canned dog food at a dosage of 50 mg/kg body weight. Each of 2 treatment regimens tested was initiated on the 40th day of pregnancy. One regimen involved daily treatment continuing through the 14th postpartum day, and it resulted in 89% fewer ascarids and 99% fewer hookworms in pups born to medicated bitches, as compared with pups born to unmedicated controls. The other regimen of treatment, which was stopped on the day of parturition, was less effective in reducing ascarid and hookworm burdens (64% and 88% reductions, respectively). Three to 5 bitches from each of the treatment and control groups were allowed to whelp a 2nd litter without further treatment or further exposure to parasite infections. Hookworm burdens in 2nd-litter pups born of bitches that had initially received fenbendazole through the 14th postpartum day were significantly lower (P < 0.01; 85% reduction), when compared with the 2nd-litter control pups. All other parasite burdens were not significantly different. It was concluded that granulated fenbendazole is effective in reducing burdens of Ancylostoma caninum and Toxocara canis in newborn pups when the bitch is treated during the last third of pregnancy, especially when treatment (50 mg/kg/day) extends from the 40th day of pregnancy through the 14th postpartum day.

Authors+Show Affiliations

Department of Parasitology, College of Veterinary Medicine, University of Georgia, Athens 30602, USA.No affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12002591

Citation

Burke, T M., and E L. Roberson. "Fenbendazole Treatment of Pregnant Bitches to Reduce Prenatal and Lactogenic Infections of Toxocara Canis and Ancylostoma Caninum in Pups." Journal of the American Veterinary Medical Association, vol. 183, no. 9, 1983, pp. 987-90.
Burke TM, Roberson EL. Fenbendazole treatment of pregnant bitches to reduce prenatal and lactogenic infections of Toxocara canis and Ancylostoma caninum in pups. J Am Vet Med Assoc. 1983;183(9):987-90.
Burke, T. M., & Roberson, E. L. (1983). Fenbendazole treatment of pregnant bitches to reduce prenatal and lactogenic infections of Toxocara canis and Ancylostoma caninum in pups. Journal of the American Veterinary Medical Association, 183(9), 987-90.
Burke TM, Roberson EL. Fenbendazole Treatment of Pregnant Bitches to Reduce Prenatal and Lactogenic Infections of Toxocara Canis and Ancylostoma Caninum in Pups. J Am Vet Med Assoc. 1983 Nov 1;183(9):987-90. PubMed PMID: 12002591.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fenbendazole treatment of pregnant bitches to reduce prenatal and lactogenic infections of Toxocara canis and Ancylostoma caninum in pups. AU - Burke,T M, AU - Roberson,E L, PY - 1983/11/1/pubmed PY - 2002/8/3/medline PY - 1983/11/1/entrez SP - 987 EP - 90 JF - Journal of the American Veterinary Medical Association JO - J Am Vet Med Assoc VL - 183 IS - 9 N2 - A granulated formulation of fenbendazole was tested in a total of 23 treated and control, pregnant, parasite-free Beagle bitches experimentally infected with Toxocara canis and Ancylostoma caninum. The drug was administered to each treated bitch once daily in canned dog food at a dosage of 50 mg/kg body weight. Each of 2 treatment regimens tested was initiated on the 40th day of pregnancy. One regimen involved daily treatment continuing through the 14th postpartum day, and it resulted in 89% fewer ascarids and 99% fewer hookworms in pups born to medicated bitches, as compared with pups born to unmedicated controls. The other regimen of treatment, which was stopped on the day of parturition, was less effective in reducing ascarid and hookworm burdens (64% and 88% reductions, respectively). Three to 5 bitches from each of the treatment and control groups were allowed to whelp a 2nd litter without further treatment or further exposure to parasite infections. Hookworm burdens in 2nd-litter pups born of bitches that had initially received fenbendazole through the 14th postpartum day were significantly lower (P < 0.01; 85% reduction), when compared with the 2nd-litter control pups. All other parasite burdens were not significantly different. It was concluded that granulated fenbendazole is effective in reducing burdens of Ancylostoma caninum and Toxocara canis in newborn pups when the bitch is treated during the last third of pregnancy, especially when treatment (50 mg/kg/day) extends from the 40th day of pregnancy through the 14th postpartum day. SN - 0003-1488 UR - https://www.unboundmedicine.com/medline/citation/12002591/Fenbendazole_treatment_of_pregnant_bitches_to_reduce_prenatal_and_lactogenic_infections_of_Toxocara_canis_and_Ancylostoma_caninum_in_pups_ DB - PRIME DP - Unbound Medicine ER -