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Factors influencing the prevalence of gallstones in liver disease: the beneficial and harmful influences of alcohol.
Am J Gastroenterol. 2002 Apr; 97(4):905-9.AJ

Abstract

OBJECTIVE

The Patient Treatment File of the Department of Veterans Affairs comprises the computerized records of all inpatients treated in all Veterans Affairs hospitals distributed throughout the United States. This database was used to study the association between liver disease and clinically manifest cholelithiasis.

METHODS

The computerized medical records of 38,459 patients with various forms of liver disease and 69,336 controls without the diagnosis were extracted from the annual files between 1990 and 1993. In a multiple logistic regression analysis, the occurrence of cholelithiasis served as the outcome variable, whereas different forms of liver disease and demographic characteristics, such as age, gender, and ethnicity, served as predictor variables.

RESULTS

Among the control population, cholelithiasis was reported in 5.2% (3,571 of 69,336) of subjects. Cholelithiasis occurred in 7.5% (2,898 of 38,459) of patients with all liver disease, 9.5% (1,642 of 17,287) of patients with alcoholic liver cirrhosis, 13.7% (981 of 7,149) of patients with nonalcoholic liver cirrhosis, and 9.1% (66 of 728) of patients with alcoholic fatty liver (chi2 = 1059, df = 4, p < 0.001). In the logistic regression, the odds ratios (ORs) for cholelithiasis associated with various forms of liver disease were: in all liver diseases combined (OR = 1.31, 95% CI = 1.25-1.38), in alcoholic liver cirrhosis (OR = 1.62, 95% CI = 1.54-1.72), in nonalcoholic liver cirrhosis (OR = 2.07, 95% CI = 1.94-2.21), and in alcoholic fatty liver (OR = 1.40, 95% CI = 1.11-1.75). Other risk factors for cholelithiasis besides liver disease were: female gender (OR = 1.43, 95% CI = 1.25-1.63), older age (OR = 1.28 per age decade, 95% CI = 1.26-1.30), Native American (OR = 1.38, 95% CI = 1.12-1.72) or Hispanic ethnicity (OR = 1.25, 95% CI = 1.15-1.35), and presence of diabetes mellitus (OR = 1.43, 95% CI = 1.35-1.52). A history of alcoholism exerted a protective influence (OR = 0.92, 95% CI = 0.87-0.97).

CONCLUSION

Gallstone disease occurs frequently in hospitalized patients with chronic liver disease or liver cirrhosis and contributes to the burden of the disease.

Authors+Show Affiliations

Department of Veterans Affairs Medical Center and The University of New Mexico, Albuquerque 87108, USA.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12003426

Citation

Buchner, Anna M., and Amnon Sonnenberg. "Factors Influencing the Prevalence of Gallstones in Liver Disease: the Beneficial and Harmful Influences of Alcohol." The American Journal of Gastroenterology, vol. 97, no. 4, 2002, pp. 905-9.
Buchner AM, Sonnenberg A. Factors influencing the prevalence of gallstones in liver disease: the beneficial and harmful influences of alcohol. Am J Gastroenterol. 2002;97(4):905-9.
Buchner, A. M., & Sonnenberg, A. (2002). Factors influencing the prevalence of gallstones in liver disease: the beneficial and harmful influences of alcohol. The American Journal of Gastroenterology, 97(4), 905-9.
Buchner AM, Sonnenberg A. Factors Influencing the Prevalence of Gallstones in Liver Disease: the Beneficial and Harmful Influences of Alcohol. Am J Gastroenterol. 2002;97(4):905-9. PubMed PMID: 12003426.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Factors influencing the prevalence of gallstones in liver disease: the beneficial and harmful influences of alcohol. AU - Buchner,Anna M, AU - Sonnenberg,Amnon, PY - 2002/5/11/pubmed PY - 2002/6/5/medline PY - 2002/5/11/entrez SP - 905 EP - 9 JF - The American journal of gastroenterology JO - Am J Gastroenterol VL - 97 IS - 4 N2 - OBJECTIVE: The Patient Treatment File of the Department of Veterans Affairs comprises the computerized records of all inpatients treated in all Veterans Affairs hospitals distributed throughout the United States. This database was used to study the association between liver disease and clinically manifest cholelithiasis. METHODS: The computerized medical records of 38,459 patients with various forms of liver disease and 69,336 controls without the diagnosis were extracted from the annual files between 1990 and 1993. In a multiple logistic regression analysis, the occurrence of cholelithiasis served as the outcome variable, whereas different forms of liver disease and demographic characteristics, such as age, gender, and ethnicity, served as predictor variables. RESULTS: Among the control population, cholelithiasis was reported in 5.2% (3,571 of 69,336) of subjects. Cholelithiasis occurred in 7.5% (2,898 of 38,459) of patients with all liver disease, 9.5% (1,642 of 17,287) of patients with alcoholic liver cirrhosis, 13.7% (981 of 7,149) of patients with nonalcoholic liver cirrhosis, and 9.1% (66 of 728) of patients with alcoholic fatty liver (chi2 = 1059, df = 4, p < 0.001). In the logistic regression, the odds ratios (ORs) for cholelithiasis associated with various forms of liver disease were: in all liver diseases combined (OR = 1.31, 95% CI = 1.25-1.38), in alcoholic liver cirrhosis (OR = 1.62, 95% CI = 1.54-1.72), in nonalcoholic liver cirrhosis (OR = 2.07, 95% CI = 1.94-2.21), and in alcoholic fatty liver (OR = 1.40, 95% CI = 1.11-1.75). Other risk factors for cholelithiasis besides liver disease were: female gender (OR = 1.43, 95% CI = 1.25-1.63), older age (OR = 1.28 per age decade, 95% CI = 1.26-1.30), Native American (OR = 1.38, 95% CI = 1.12-1.72) or Hispanic ethnicity (OR = 1.25, 95% CI = 1.15-1.35), and presence of diabetes mellitus (OR = 1.43, 95% CI = 1.35-1.52). A history of alcoholism exerted a protective influence (OR = 0.92, 95% CI = 0.87-0.97). CONCLUSION: Gallstone disease occurs frequently in hospitalized patients with chronic liver disease or liver cirrhosis and contributes to the burden of the disease. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/12003426/Factors_influencing_the_prevalence_of_gallstones_in_liver_disease:_the_beneficial_and_harmful_influences_of_alcohol_ L2 - https://Insights.ovid.com/pubmed?pmid=12003426 DB - PRIME DP - Unbound Medicine ER -