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alpha(2)-Adrenergic receptors in NTS facilitate baroreflex function in adult spontaneously hypertensive rats.
. 2002 Jun; 282(6):H2336-45.

Abstract

We examined the effect of alpha(2)-adrenoreceptor blockade in the nucleus of the solitary tract (NTS) on baroreflex responses elicited by electrical stimulation of the left aortic depressor nerve (ADN) in urethane-anesthetized spontaneously hypertensive rats (SHR, n = 11) and normotensive Wistar-Kyoto rats (WKY, n = 11). ADN stimulation produced a frequency-dependent decrease in mean arterial pressure (MAP), renal sympathetic nerve activity (RSNA), and heart rate (HR). In SHR, unilateral microinjection of idazoxan into the NTS markedly reduced baroreflex control of MAP, RSNA, and HR and had a disproportionately greater influence on baroreflex control of MAP than of RSNA. In WKY, idazoxan microinjections did not significantly alter baroreflex function relative to control vehicle injections. These results suggest that baroreflex regulation of arterial pressure in SHR is highly dependent on NTS adrenergic mechanisms. The reflex regulation of sympathetic outflow to the kidney is less influenced by the altered alpha(2)-adrenoreceptor mechanisms in SHR.

Authors+Show Affiliations

Cardiovascular Center and Department of Internal Medicine, University of Iowa and Research Service of the Department of Veterans Affairs Medical Center, Iowa City, Iowa 52242, USA. lindah@ufl.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12003844

Citation

Hayward, Linda F., et al. "Alpha(2)-Adrenergic Receptors in NTS Facilitate Baroreflex Function in Adult Spontaneously Hypertensive Rats." American Journal of Physiology. Heart and Circulatory Physiology, vol. 282, no. 6, 2002, pp. H2336-45.
Hayward LF, Riley AP, Felder RB. Alpha(2)-Adrenergic receptors in NTS facilitate baroreflex function in adult spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol. 2002;282(6):H2336-45.
Hayward, L. F., Riley, A. P., & Felder, R. B. (2002). Alpha(2)-Adrenergic receptors in NTS facilitate baroreflex function in adult spontaneously hypertensive rats. American Journal of Physiology. Heart and Circulatory Physiology, 282(6), H2336-45.
Hayward LF, Riley AP, Felder RB. Alpha(2)-Adrenergic Receptors in NTS Facilitate Baroreflex Function in Adult Spontaneously Hypertensive Rats. Am J Physiol Heart Circ Physiol. 2002;282(6):H2336-45. PubMed PMID: 12003844.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - alpha(2)-Adrenergic receptors in NTS facilitate baroreflex function in adult spontaneously hypertensive rats. AU - Hayward,Linda F, AU - Riley,Alecia P, AU - Felder,Robert B, PY - 2002/5/11/pubmed PY - 2002/6/21/medline PY - 2002/5/11/entrez SP - H2336 EP - 45 JF - American journal of physiology. Heart and circulatory physiology JO - Am. J. Physiol. Heart Circ. Physiol. VL - 282 IS - 6 N2 - We examined the effect of alpha(2)-adrenoreceptor blockade in the nucleus of the solitary tract (NTS) on baroreflex responses elicited by electrical stimulation of the left aortic depressor nerve (ADN) in urethane-anesthetized spontaneously hypertensive rats (SHR, n = 11) and normotensive Wistar-Kyoto rats (WKY, n = 11). ADN stimulation produced a frequency-dependent decrease in mean arterial pressure (MAP), renal sympathetic nerve activity (RSNA), and heart rate (HR). In SHR, unilateral microinjection of idazoxan into the NTS markedly reduced baroreflex control of MAP, RSNA, and HR and had a disproportionately greater influence on baroreflex control of MAP than of RSNA. In WKY, idazoxan microinjections did not significantly alter baroreflex function relative to control vehicle injections. These results suggest that baroreflex regulation of arterial pressure in SHR is highly dependent on NTS adrenergic mechanisms. The reflex regulation of sympathetic outflow to the kidney is less influenced by the altered alpha(2)-adrenoreceptor mechanisms in SHR. SN - 0363-6135 UR - https://www.unboundmedicine.com/medline/citation/12003844/alpha_2__Adrenergic_receptors_in_NTS_facilitate_baroreflex_function_in_adult_spontaneously_hypertensive_rats_ L2 - https://journals.physiology.org/doi/10.1152/ajpheart.00167.2001?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -