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Antibiotic tolerance of peritoneal bacterial isolates in dialysis fluids.
J Antimicrob Chemother. 2002 May; 49(5):863-6.JA

Abstract

The objective was to test antibiotic activity against Staphylococcus epidermidis and Pseudomonas aeruginosa in fresh dianeal fluid and spent dialysate from patients undergoing chronic ambulatory peritoneal dialysis. MICs and MBCs were measured and compared with those in standard broth. For S. epidermidis, there was some reduction in cefazolin and vancomycin activity in dialysis fluids. For P. aeruginosa, ciprofloxacin and tobramycin MICs increased significantly, and all isolates were tolerant to ceftazidime and piperacillin in dialysis fluids. Dialysis fluids can significantly impair antibiotic activity. The clinical implications warrant further study of antibiotic pharmacodynamics in the treatment of peritonitis.

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Authors+Show Affiliations

Zelenitsky S
Faculty of Pharmacy, University of Manitoba, Winnipeg, Canada. Zelentis@ms.umanitoba.ca
Franczuk C
No affiliation info available
Fine A
No affiliation info available
Ariano R
No affiliation info available
Harding G
No affiliation info available

MeSH

Anti-Bacterial AgentsBacteriaCulture MediaDrug Resistance, MicrobialMethicillin ResistanceMicrobial Sensitivity TestsPeritoneal CavityPeritoneal DialysisPseudomonas aeruginosaStaphylococcus epidermidis

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12003985

Citation

Zelenitsky, Sheryl, et al. "Antibiotic Tolerance of Peritoneal Bacterial Isolates in Dialysis Fluids." The Journal of Antimicrobial Chemotherapy, vol. 49, no. 5, 2002, pp. 863-6.
Zelenitsky S, Franczuk C, Fine A, et al. Antibiotic tolerance of peritoneal bacterial isolates in dialysis fluids. J Antimicrob Chemother. 2002;49(5):863-6.
Zelenitsky, S., Franczuk, C., Fine, A., Ariano, R., & Harding, G. (2002). Antibiotic tolerance of peritoneal bacterial isolates in dialysis fluids. The Journal of Antimicrobial Chemotherapy, 49(5), 863-6.
Zelenitsky S, et al. Antibiotic Tolerance of Peritoneal Bacterial Isolates in Dialysis Fluids. J Antimicrob Chemother. 2002;49(5):863-6. PubMed PMID: 12003985.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antibiotic tolerance of peritoneal bacterial isolates in dialysis fluids. AU - Zelenitsky,Sheryl, AU - Franczuk,Christine, AU - Fine,Adrian, AU - Ariano,Robert, AU - Harding,Godfrey, PY - 2002/5/11/pubmed PY - 2002/11/30/medline PY - 2002/5/11/entrez SP - 863 EP - 6 JF - The Journal of antimicrobial chemotherapy JO - J Antimicrob Chemother VL - 49 IS - 5 N2 - The objective was to test antibiotic activity against Staphylococcus epidermidis and Pseudomonas aeruginosa in fresh dianeal fluid and spent dialysate from patients undergoing chronic ambulatory peritoneal dialysis. MICs and MBCs were measured and compared with those in standard broth. For S. epidermidis, there was some reduction in cefazolin and vancomycin activity in dialysis fluids. For P. aeruginosa, ciprofloxacin and tobramycin MICs increased significantly, and all isolates were tolerant to ceftazidime and piperacillin in dialysis fluids. Dialysis fluids can significantly impair antibiotic activity. The clinical implications warrant further study of antibiotic pharmacodynamics in the treatment of peritonitis. SN - 0305-7453 UR - https://www.unboundmedicine.com/medline/citation/12003985/Antibiotic_tolerance_of_peritoneal_bacterial_isolates_in_dialysis_fluids_ L2 - https://academic.oup.com/jac/article-lookup/doi/10.1093/jac/dkf006 DB - PRIME DP - Unbound Medicine ER -