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Alcohol drinking and risk of hemorrhagic stroke.

Abstract

In view of conflicting prior reports, we prospectively studied associations between alcohol consumption and subsequent hospitalization for hemorrhagic stroke (HS) in 431 persons. Alcohol use was determined at examinations in 1978-1984 among 128,934 members of a prepaid health plan. Cox proportional hazards models, with 6 covariates, yielded the following multivariate relative risks (95% CI's) for HS: lifelong abstainers (ref) = 1.0, exdrinkers = 0.9 (0.5-1.5), persons drinking <1/month = 1.1 (0.8-1.4), >1/month; <1 drink/day = 0.7 (0.5-0.9), 1-2/day = 0.8 (0.6-1.1), 3-5/day = 1.0 (0.6-1.5), 6+/day = 1.9 (1.0-3.5). Relationships to alcohol were similar for subarachnoid (31% of HS) or intracerebral hemorrhage (69% of HS) and in men or women. Beverage choice (wine, beer, and liquor) was not independently related. We conclude that only heavy drinking is weakly related to increased HS risk and that light drinking need not be proscribed with respect to HS risk.

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  • Authors+Show Affiliations

    ,

    Division of Cardiology, Department of Medicine, Kaiser Permanente Medical Center, Oakland, Calif 94611, USA. hartmavn@pacbell.net

    , ,

    Source

    Neuroepidemiology 21:3 pg 115-22

    MeSH

    Adult
    Alcohol Drinking
    California
    Cohort Studies
    Female
    Humans
    Male
    Middle Aged
    Prospective Studies
    Risk Factors
    Stroke

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    12006774

    Citation

    Klatsky, Arthur L., et al. "Alcohol Drinking and Risk of Hemorrhagic Stroke." Neuroepidemiology, vol. 21, no. 3, 2002, pp. 115-22.
    Klatsky AL, Armstrong MA, Friedman GD, et al. Alcohol drinking and risk of hemorrhagic stroke. Neuroepidemiology. 2002;21(3):115-22.
    Klatsky, A. L., Armstrong, M. A., Friedman, G. D., & Sidney, S. (2002). Alcohol drinking and risk of hemorrhagic stroke. Neuroepidemiology, 21(3), pp. 115-22.
    Klatsky AL, et al. Alcohol Drinking and Risk of Hemorrhagic Stroke. Neuroepidemiology. 2002;21(3):115-22. PubMed PMID: 12006774.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Alcohol drinking and risk of hemorrhagic stroke. AU - Klatsky,Arthur L, AU - Armstrong,Mary Anne, AU - Friedman,Gary D, AU - Sidney,Stephen, PY - 2002/5/15/pubmed PY - 2002/8/22/medline PY - 2002/5/15/entrez SP - 115 EP - 22 JF - Neuroepidemiology JO - Neuroepidemiology VL - 21 IS - 3 N2 - In view of conflicting prior reports, we prospectively studied associations between alcohol consumption and subsequent hospitalization for hemorrhagic stroke (HS) in 431 persons. Alcohol use was determined at examinations in 1978-1984 among 128,934 members of a prepaid health plan. Cox proportional hazards models, with 6 covariates, yielded the following multivariate relative risks (95% CI's) for HS: lifelong abstainers (ref) = 1.0, exdrinkers = 0.9 (0.5-1.5), persons drinking <1/month = 1.1 (0.8-1.4), >1/month; <1 drink/day = 0.7 (0.5-0.9), 1-2/day = 0.8 (0.6-1.1), 3-5/day = 1.0 (0.6-1.5), 6+/day = 1.9 (1.0-3.5). Relationships to alcohol were similar for subarachnoid (31% of HS) or intracerebral hemorrhage (69% of HS) and in men or women. Beverage choice (wine, beer, and liquor) was not independently related. We conclude that only heavy drinking is weakly related to increased HS risk and that light drinking need not be proscribed with respect to HS risk. SN - 0251-5350 UR - https://www.unboundmedicine.com/medline/citation/12006774/Alcohol_drinking_and_risk_of_hemorrhagic_stroke_ L2 - https://www.karger.com?DOI=10.1159/000054808 DB - PRIME DP - Unbound Medicine ER -