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Bedside microdialysis: a tool to monitor cerebral metabolism in subarachnoid hemorrhage patients?
Crit Care Med. 2002 May; 30(5):1062-70.CC

Abstract

OBJECTIVE

To analyze the time course and changes of cerebral microdialysis parameters after aneurysmal subarachnoid hemorrhage (SAH) in respect to the clinical course (asymptomatic, delayed, and acute ischemic neurologic deficits) to evaluate the method of bedside microdialysis in these patients.

DESIGN

Prospective, controlled study during a 3-yr period.

SETTING

Neurosurgical intensive care unit at a primary level university hospital, supervised and staffed by members of both the department of neurosurgery and the department of anesthesiology and intensive care medicine.

PATIENTS

Ninety-seven patients (51 females/21 males; 52 +/- 13 yrs; World Federation of Neurological Surgeons Scale grades 0-5) after aneurysmatic SAH.

MEASUREMENTS AND MAIN RESULTS

A microdialysis catheter (CMA 100) was inserted into the region most likely to be affected by vasospasm directly after aneurysm clipping, connected to a pump, and perfused with Ringer solution (0.3 microL/min). The dialysates were collected hourly and analyzed at the bedside for glucose, lactate, lactate-pyruvate ratio, glutamate, and glycerol (CMA 600). Patients were classified according to clinical presentation as being asymptomatic or having acute (AIND) or delayed (DIND) ischemic neurologic deficits. DIND patients (n = 18) had significantly higher lactate and glutamate concentrations on days 1-8 post-SAH and a higher lactate-pyruvate ratio on days 3-8 post-SAH compared with asymptomatic patients (n = 57; p <.025). Glucose and glycerol levels did not differ in asymptomatic and DIND patients. AIND patients (n = 22) had the worst metabolic pattern: the extracellular glucose concentration was low, whereas the lactate, lactate-pyruvate ratio, glutamate, and glycerol levels were significantly elevated compared with asymptomatic and DIND patients. In 83% of the DIND patients, the changes in metabolites indicative of cerebral ischemia preceded the onset of symptomatic vasospasm. All DIND patients clinically improved in their Glasgow Coma Scale scores with induced hypertension, intentional hypervolemia, and/or hemodilution therapy (p =.01).

CONCLUSION

Cerebral bedside microdialysis is a safe and promising technique for monitoring (impending) regional cerebral ischemia. The dialysate changes can indicate early the onset of delayed neurologic deterioration and are in good accordance with the clinical course of SAH patients. In the future, this technique may be used to monitor the efficacy of the intensive care therapy of these patients.

Authors+Show Affiliations

Clinic of Neurosurgery, Charité Campus Virchow Medical Clinic, Humboldt University of Berlin, Berlin, Germany. asita.sarrafzadeh@charite.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12006804

Citation

Sarrafzadeh, Asita S., et al. "Bedside Microdialysis: a Tool to Monitor Cerebral Metabolism in Subarachnoid Hemorrhage Patients?" Critical Care Medicine, vol. 30, no. 5, 2002, pp. 1062-70.
Sarrafzadeh AS, Sakowitz OW, Kiening KL, et al. Bedside microdialysis: a tool to monitor cerebral metabolism in subarachnoid hemorrhage patients? Crit Care Med. 2002;30(5):1062-70.
Sarrafzadeh, A. S., Sakowitz, O. W., Kiening, K. L., Benndorf, G., Lanksch, W. R., & Unterberg, A. W. (2002). Bedside microdialysis: a tool to monitor cerebral metabolism in subarachnoid hemorrhage patients? Critical Care Medicine, 30(5), 1062-70.
Sarrafzadeh AS, et al. Bedside Microdialysis: a Tool to Monitor Cerebral Metabolism in Subarachnoid Hemorrhage Patients. Crit Care Med. 2002;30(5):1062-70. PubMed PMID: 12006804.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bedside microdialysis: a tool to monitor cerebral metabolism in subarachnoid hemorrhage patients? AU - Sarrafzadeh,Asita S, AU - Sakowitz,Oliver W, AU - Kiening,Karl L, AU - Benndorf,Goetz, AU - Lanksch,Wolfgang R, AU - Unterberg,Andreas W, PY - 2002/5/15/pubmed PY - 2002/6/12/medline PY - 2002/5/15/entrez SP - 1062 EP - 70 JF - Critical care medicine JO - Crit. Care Med. VL - 30 IS - 5 N2 - OBJECTIVE: To analyze the time course and changes of cerebral microdialysis parameters after aneurysmal subarachnoid hemorrhage (SAH) in respect to the clinical course (asymptomatic, delayed, and acute ischemic neurologic deficits) to evaluate the method of bedside microdialysis in these patients. DESIGN: Prospective, controlled study during a 3-yr period. SETTING: Neurosurgical intensive care unit at a primary level university hospital, supervised and staffed by members of both the department of neurosurgery and the department of anesthesiology and intensive care medicine. PATIENTS: Ninety-seven patients (51 females/21 males; 52 +/- 13 yrs; World Federation of Neurological Surgeons Scale grades 0-5) after aneurysmatic SAH. MEASUREMENTS AND MAIN RESULTS: A microdialysis catheter (CMA 100) was inserted into the region most likely to be affected by vasospasm directly after aneurysm clipping, connected to a pump, and perfused with Ringer solution (0.3 microL/min). The dialysates were collected hourly and analyzed at the bedside for glucose, lactate, lactate-pyruvate ratio, glutamate, and glycerol (CMA 600). Patients were classified according to clinical presentation as being asymptomatic or having acute (AIND) or delayed (DIND) ischemic neurologic deficits. DIND patients (n = 18) had significantly higher lactate and glutamate concentrations on days 1-8 post-SAH and a higher lactate-pyruvate ratio on days 3-8 post-SAH compared with asymptomatic patients (n = 57; p <.025). Glucose and glycerol levels did not differ in asymptomatic and DIND patients. AIND patients (n = 22) had the worst metabolic pattern: the extracellular glucose concentration was low, whereas the lactate, lactate-pyruvate ratio, glutamate, and glycerol levels were significantly elevated compared with asymptomatic and DIND patients. In 83% of the DIND patients, the changes in metabolites indicative of cerebral ischemia preceded the onset of symptomatic vasospasm. All DIND patients clinically improved in their Glasgow Coma Scale scores with induced hypertension, intentional hypervolemia, and/or hemodilution therapy (p =.01). CONCLUSION: Cerebral bedside microdialysis is a safe and promising technique for monitoring (impending) regional cerebral ischemia. The dialysate changes can indicate early the onset of delayed neurologic deterioration and are in good accordance with the clinical course of SAH patients. In the future, this technique may be used to monitor the efficacy of the intensive care therapy of these patients. SN - 0090-3493 UR - https://www.unboundmedicine.com/medline/citation/12006804/Bedside_microdialysis:_a_tool_to_monitor_cerebral_metabolism_in_subarachnoid_hemorrhage_patients L2 - https://dx.doi.org/10.1097/00003246-200205000-00018 DB - PRIME DP - Unbound Medicine ER -