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Influence of type 2 diabetes mellitus on cardiovascular disease mortality: findings from the Hawaii-Los Angeles-Hiroshima study.
Diabetes Res Clin Pract 2002; 57(1):61-9DR

Abstract

The present study addressed whether diabetes mellitus was a strong risk factor for cardiovascular disease (CVD) death. Between 1976 and 1984, 927 (404 men) Japanese-Americans in Hawaii aged 40-79 years participated at baseline examination including a 75 g oral glucose tolerance test. Diabetes was defined as fasting serum glucose >or=140 mg/dl, 2 h postload glucose >or=180 mg/dl, or the use of drugs for diabetes. Causes of death were classified by ICD-9 codes on the reports from the Hawaii State Public Health Bureau. Until 1994, 178 individuals suffered death; 81 were attributed to CVD and 43 to coronary heart disease (CHD). The age-adjusted and coronary risk factors-adjusted relative risks for CHD and CVD mortality were significant for diabetes both in men and women. The impact of diabetes on CHD mortality was greater for women. However, no gender difference in the contribution of diabetes to fatal CVD was observed. Serum fasting glucose levels tended to be associated with CHD death and were associated with CVD death in diabetic subjects. In conclusion, diabetes is a strong independent risk factor for CVD mortality in Japanese-American men and women. Hyperglycemia is associated with CVD mortality in diabetic subjects.

Authors+Show Affiliations

Second Department of Internal Medicine, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minami-ku, Hiroshima-city, Japan. imazu@hiroshima-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

12007731

Citation

Imazu, Michinori, et al. "Influence of Type 2 Diabetes Mellitus On Cardiovascular Disease Mortality: Findings From the Hawaii-Los Angeles-Hiroshima Study." Diabetes Research and Clinical Practice, vol. 57, no. 1, 2002, pp. 61-9.
Imazu M, Sumii K, Yamamoto H, et al. Influence of type 2 diabetes mellitus on cardiovascular disease mortality: findings from the Hawaii-Los Angeles-Hiroshima study. Diabetes Res Clin Pract. 2002;57(1):61-9.
Imazu, M., Sumii, K., Yamamoto, H., Toyofuku, M., Tadehara, F., Okubo, M., ... Onaka, A. T. (2002). Influence of type 2 diabetes mellitus on cardiovascular disease mortality: findings from the Hawaii-Los Angeles-Hiroshima study. Diabetes Research and Clinical Practice, 57(1), pp. 61-9.
Imazu M, et al. Influence of Type 2 Diabetes Mellitus On Cardiovascular Disease Mortality: Findings From the Hawaii-Los Angeles-Hiroshima Study. Diabetes Res Clin Pract. 2002;57(1):61-9. PubMed PMID: 12007731.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of type 2 diabetes mellitus on cardiovascular disease mortality: findings from the Hawaii-Los Angeles-Hiroshima study. AU - Imazu,Michinori, AU - Sumii,Kotaro, AU - Yamamoto,Hideya, AU - Toyofuku,Mamoru, AU - Tadehara,Futoshi, AU - Okubo,Masamichi, AU - Yamakido,Michio, AU - Kohno,Nobuoki, AU - Onaka,Alvin T, AU - ,, PY - 2002/5/15/pubmed PY - 2002/9/6/medline PY - 2002/5/15/entrez SP - 61 EP - 9 JF - Diabetes research and clinical practice JO - Diabetes Res. Clin. Pract. VL - 57 IS - 1 N2 - The present study addressed whether diabetes mellitus was a strong risk factor for cardiovascular disease (CVD) death. Between 1976 and 1984, 927 (404 men) Japanese-Americans in Hawaii aged 40-79 years participated at baseline examination including a 75 g oral glucose tolerance test. Diabetes was defined as fasting serum glucose >or=140 mg/dl, 2 h postload glucose >or=180 mg/dl, or the use of drugs for diabetes. Causes of death were classified by ICD-9 codes on the reports from the Hawaii State Public Health Bureau. Until 1994, 178 individuals suffered death; 81 were attributed to CVD and 43 to coronary heart disease (CHD). The age-adjusted and coronary risk factors-adjusted relative risks for CHD and CVD mortality were significant for diabetes both in men and women. The impact of diabetes on CHD mortality was greater for women. However, no gender difference in the contribution of diabetes to fatal CVD was observed. Serum fasting glucose levels tended to be associated with CHD death and were associated with CVD death in diabetic subjects. In conclusion, diabetes is a strong independent risk factor for CVD mortality in Japanese-American men and women. Hyperglycemia is associated with CVD mortality in diabetic subjects. SN - 0168-8227 UR - https://www.unboundmedicine.com/medline/citation/12007731/Influence_of_type_2_diabetes_mellitus_on_cardiovascular_disease_mortality:_findings_from_the_Hawaii_Los_Angeles_Hiroshima_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168822702000165 DB - PRIME DP - Unbound Medicine ER -