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Oxidative stress and peritoneal endometriosis.
Fertil Steril 2002; 77(5):861-70FS

Abstract

OBJECTIVE

To review the literature associating pelvic endometriosis with oxidative stress and to discuss the potential causes and consequences of a pro-oxidant environment in the peritoneal cavity.

DESIGN

Literature survey.

RESULT(S)

Several studies suggest that oxidative stress is a component of the inflammatory reaction associated with endometriosis. Evidence includes the prevention of endometriosis induction in rabbits by the addition of antioxidants, an increase in reactive oxygen species release by macrophages, increased peritoneal levels of oxidized low-density lipoproteins and their by-products, altered expression of endometrial pro-oxidant and antioxidant enzymes, and consumption of peritoneal fluid vitamin E. Retrograde menstruation is likely to carry highly pro-oxidant factors, such as heme and iron, into the peritoneal cavity, as well as apoptotic endometrial cells, which are well-known inducers of oxidative stress. Reactive oxygen species may be involved in endometriosis-associated infertility and may play a role in the regulation of the expression of genes encoding immunoregulators, cytokines and cell adhesion molecules implicated in the pathogenesis of endometriosis.

CONCLUSION(S)

Better understanding of the mechanisms of reactive oxygen species production and detoxification and further investigation of their effect on the peritoneal environment are essential to obtain new insight into this disease and eventually develop new diagnostic and therapeutic strategies.

Authors+Show Affiliations

Department of Gynecology, Université Catholique de Louvain, Brussels, Belgium.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

12009336

Citation

Van Langendonckt, Anne, et al. "Oxidative Stress and Peritoneal Endometriosis." Fertility and Sterility, vol. 77, no. 5, 2002, pp. 861-70.
Van Langendonckt A, Casanas-Roux F, Donnez J. Oxidative stress and peritoneal endometriosis. Fertil Steril. 2002;77(5):861-70.
Van Langendonckt, A., Casanas-Roux, F., & Donnez, J. (2002). Oxidative stress and peritoneal endometriosis. Fertility and Sterility, 77(5), pp. 861-70.
Van Langendonckt A, Casanas-Roux F, Donnez J. Oxidative Stress and Peritoneal Endometriosis. Fertil Steril. 2002;77(5):861-70. PubMed PMID: 12009336.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidative stress and peritoneal endometriosis. AU - Van Langendonckt,Anne, AU - Casanas-Roux,Françoise, AU - Donnez,Jacques, PY - 2002/5/16/pubmed PY - 2003/12/3/medline PY - 2002/5/16/entrez SP - 861 EP - 70 JF - Fertility and sterility JO - Fertil. Steril. VL - 77 IS - 5 N2 - OBJECTIVE: To review the literature associating pelvic endometriosis with oxidative stress and to discuss the potential causes and consequences of a pro-oxidant environment in the peritoneal cavity. DESIGN: Literature survey. RESULT(S): Several studies suggest that oxidative stress is a component of the inflammatory reaction associated with endometriosis. Evidence includes the prevention of endometriosis induction in rabbits by the addition of antioxidants, an increase in reactive oxygen species release by macrophages, increased peritoneal levels of oxidized low-density lipoproteins and their by-products, altered expression of endometrial pro-oxidant and antioxidant enzymes, and consumption of peritoneal fluid vitamin E. Retrograde menstruation is likely to carry highly pro-oxidant factors, such as heme and iron, into the peritoneal cavity, as well as apoptotic endometrial cells, which are well-known inducers of oxidative stress. Reactive oxygen species may be involved in endometriosis-associated infertility and may play a role in the regulation of the expression of genes encoding immunoregulators, cytokines and cell adhesion molecules implicated in the pathogenesis of endometriosis. CONCLUSION(S): Better understanding of the mechanisms of reactive oxygen species production and detoxification and further investigation of their effect on the peritoneal environment are essential to obtain new insight into this disease and eventually develop new diagnostic and therapeutic strategies. SN - 0015-0282 UR - https://www.unboundmedicine.com/medline/citation/12009336/Oxidative_stress_and_peritoneal_endometriosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S001502820202959X DB - PRIME DP - Unbound Medicine ER -