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Endocrine and cytokine responses to acute psychological stress in multiple sclerosis.
Brain Behav Immun 2002; 16(3):282-7BB

Abstract

Multiple sclerosis (MS) is an autoimmune disease affecting the central nervous system. An impaired hypothalamopituitary axis and stress reactivity have extensively been discussed without convincing experimental evidence. We choose a standardized acute psychological stressor to determine whether MS patients show altered endocrine and immune responses to stress. In 35 relapsing-remitting MS patients we found elevated baseline levels for catecholamines, prolactin, and IL-6 compared to 15 healthy controls. All neuroendocrine parameters declined during the stress intervention in MS as well as in stress-exposed controls. But only prolactin showed a significantly larger decline in stressed MS patients versus controls. During exposure to the stress we found no significant changes in serum levels of IL-6, IL-6 receptor, or TNF-alpha in either MS patients or controls after stimulation of a whole blood culture. An altered neural immune signaling in relapsing-remitting MS patients during acute experimental stress could not be proven for the parameters analyzed.

Authors+Show Affiliations

Department of Neurology, University Hospital Hamburg-Eppendorf, Hamburg, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12009688

Citation

Heesen, Christoph, et al. "Endocrine and Cytokine Responses to Acute Psychological Stress in Multiple Sclerosis." Brain, Behavior, and Immunity, vol. 16, no. 3, 2002, pp. 282-7.
Heesen C, Schulz H, Schmidt M, et al. Endocrine and cytokine responses to acute psychological stress in multiple sclerosis. Brain Behav Immun. 2002;16(3):282-7.
Heesen, C., Schulz, H., Schmidt, M., Gold, S., Tessmer, W., & Schulz, K. H. (2002). Endocrine and cytokine responses to acute psychological stress in multiple sclerosis. Brain, Behavior, and Immunity, 16(3), pp. 282-7.
Heesen C, et al. Endocrine and Cytokine Responses to Acute Psychological Stress in Multiple Sclerosis. Brain Behav Immun. 2002;16(3):282-7. PubMed PMID: 12009688.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Endocrine and cytokine responses to acute psychological stress in multiple sclerosis. AU - Heesen,Christoph, AU - Schulz,Holger, AU - Schmidt,Michaela, AU - Gold,Stefan, AU - Tessmer,Wiebke, AU - Schulz,Karl-Heinz, PY - 2002/5/16/pubmed PY - 2002/6/29/medline PY - 2002/5/16/entrez SP - 282 EP - 7 JF - Brain, behavior, and immunity JO - Brain Behav. Immun. VL - 16 IS - 3 N2 - Multiple sclerosis (MS) is an autoimmune disease affecting the central nervous system. An impaired hypothalamopituitary axis and stress reactivity have extensively been discussed without convincing experimental evidence. We choose a standardized acute psychological stressor to determine whether MS patients show altered endocrine and immune responses to stress. In 35 relapsing-remitting MS patients we found elevated baseline levels for catecholamines, prolactin, and IL-6 compared to 15 healthy controls. All neuroendocrine parameters declined during the stress intervention in MS as well as in stress-exposed controls. But only prolactin showed a significantly larger decline in stressed MS patients versus controls. During exposure to the stress we found no significant changes in serum levels of IL-6, IL-6 receptor, or TNF-alpha in either MS patients or controls after stimulation of a whole blood culture. An altered neural immune signaling in relapsing-remitting MS patients during acute experimental stress could not be proven for the parameters analyzed. SN - 0889-1591 UR - https://www.unboundmedicine.com/medline/citation/12009688/Endocrine_and_cytokine_responses_to_acute_psychological_stress_in_multiple_sclerosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0889159101906282 DB - PRIME DP - Unbound Medicine ER -