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Eicosapentaenoic acid and docosahexaenoic acid from fish oils: differential associations with lipid responses.
Br J Nutr. 2002 May; 87(5):435-45.BJ

Abstract

Fish-oil supplementation can reduce circulating triacylglycerol (TG) levels and cardiovascular risk. This study aimed to assess independent associations between changes in platelet eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and fasting and postprandial (PP) lipoprotein concentrations and LDL oxidation status, following fish-oil intervention. Fifty-five mildly hypertriacylglycerolaemic (TG 1.5-4.0 mmol/l) men completed a double-blind placebo controlled cross over study, where individuals consumed 6 g fish oil (3 g EPA+DHA) or 6 g olive oil (placebo)/d for two 6-week intervention periods, with a 12-week wash-out period in between. Fish-oil intervention resulted in a significant increase in the platelet phospholipid EPA (+491 %, P<0.001) and DHA (+44 %, P<0.001) content and a significant decrease in the arachidonic acid (-10 %, P<0.001) and gamma-linolenic acid (-24 %, P<0.001) levels. A 30 % increase in ex vivo LDL oxidation (P<0.001) was observed. In addition, fish oil resulted in a significant decrease in fasting and PP TG levels (P<0.001), PP non-esterified fatty acid (NEFA) levels, and in the percentage LDL as LDL-3 (P=0.040), and an increase in LDL-cholesterol (P=0.027). In multivariate analysis, changes in platelet phospholipid DHA emerged as being independently associated with the rise in LDL-cholesterol, accounting for 16 % of the variability in this outcome measure (P=0.030). In contrast, increases in platelet EPA were independently associated with the reductions in fasting (P=0.046) and PP TG (P=0.023), and PP NEFA (P=0.015), explaining 15-20 % and 25 % of the variability in response respectively. Increases in platelet EPA+DHA were independently and positively associated with the increase in LDL oxidation (P=0.011). EPA and DHA may have differential effects on plasma lipids in mildly hypertriacylglycerolaemic men.

Authors+Show Affiliations

The Hugh Sinclair Unit of Human Nutrition, The University of Reading, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12010583

Citation

Leigh-Firbank, Elizabeth C., et al. "Eicosapentaenoic Acid and Docosahexaenoic Acid From Fish Oils: Differential Associations With Lipid Responses." The British Journal of Nutrition, vol. 87, no. 5, 2002, pp. 435-45.
Leigh-Firbank EC, Minihane AM, Leake DS, et al. Eicosapentaenoic acid and docosahexaenoic acid from fish oils: differential associations with lipid responses. Br J Nutr. 2002;87(5):435-45.
Leigh-Firbank, E. C., Minihane, A. M., Leake, D. S., Wright, J. W., Murphy, M. C., Griffin, B. A., & Williams, C. M. (2002). Eicosapentaenoic acid and docosahexaenoic acid from fish oils: differential associations with lipid responses. The British Journal of Nutrition, 87(5), 435-45.
Leigh-Firbank EC, et al. Eicosapentaenoic Acid and Docosahexaenoic Acid From Fish Oils: Differential Associations With Lipid Responses. Br J Nutr. 2002;87(5):435-45. PubMed PMID: 12010583.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Eicosapentaenoic acid and docosahexaenoic acid from fish oils: differential associations with lipid responses. AU - Leigh-Firbank,Elizabeth C, AU - Minihane,Anne M, AU - Leake,David S, AU - Wright,John W, AU - Murphy,Margaret C, AU - Griffin,Bruce A, AU - Williams,Christine M, PY - 2002/5/16/pubmed PY - 2002/6/20/medline PY - 2002/5/16/entrez SP - 435 EP - 45 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 87 IS - 5 N2 - Fish-oil supplementation can reduce circulating triacylglycerol (TG) levels and cardiovascular risk. This study aimed to assess independent associations between changes in platelet eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and fasting and postprandial (PP) lipoprotein concentrations and LDL oxidation status, following fish-oil intervention. Fifty-five mildly hypertriacylglycerolaemic (TG 1.5-4.0 mmol/l) men completed a double-blind placebo controlled cross over study, where individuals consumed 6 g fish oil (3 g EPA+DHA) or 6 g olive oil (placebo)/d for two 6-week intervention periods, with a 12-week wash-out period in between. Fish-oil intervention resulted in a significant increase in the platelet phospholipid EPA (+491 %, P<0.001) and DHA (+44 %, P<0.001) content and a significant decrease in the arachidonic acid (-10 %, P<0.001) and gamma-linolenic acid (-24 %, P<0.001) levels. A 30 % increase in ex vivo LDL oxidation (P<0.001) was observed. In addition, fish oil resulted in a significant decrease in fasting and PP TG levels (P<0.001), PP non-esterified fatty acid (NEFA) levels, and in the percentage LDL as LDL-3 (P=0.040), and an increase in LDL-cholesterol (P=0.027). In multivariate analysis, changes in platelet phospholipid DHA emerged as being independently associated with the rise in LDL-cholesterol, accounting for 16 % of the variability in this outcome measure (P=0.030). In contrast, increases in platelet EPA were independently associated with the reductions in fasting (P=0.046) and PP TG (P=0.023), and PP NEFA (P=0.015), explaining 15-20 % and 25 % of the variability in response respectively. Increases in platelet EPA+DHA were independently and positively associated with the increase in LDL oxidation (P=0.011). EPA and DHA may have differential effects on plasma lipids in mildly hypertriacylglycerolaemic men. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/12010583/Eicosapentaenoic_acid_and_docosahexaenoic_acid_from_fish_oils:_differential_associations_with_lipid_responses_ L2 - https://www.cambridge.org/core/product/identifier/S0007114502000776/type/journal_article DB - PRIME DP - Unbound Medicine ER -