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Decreased expression of the CCAAT/enhancer binding protein alpha gene involved in hepatocyte proliferation in human hepatocellular carcinomas.
Int J Mol Med. 2002 Jun; 9(6):597-600.IJ

Abstract

CCAAT/enhancer binding protein alpha (C/EBPalpha), expressed at a high level in liver, plays an important role in proliferation and differentiation of hepatocytes. Previous studies showed that an expression level of the C/EBPalpha gene in hepatocytes was downregulated in response to proliferation signals and that forced expression of the C/EBPalpha gene in a number of cells caused cell cycle arrest. We compared the expression level of the C/EBPalpha gene in surgical specimens between hepatocellular carcinoma and non-tumorous regions of the same patients. In 9 out of 13 cases, the expression level in the tumors was decreased compared with that in corresponding non-tumorous regions. Transfection of the C/EBPalpha gene into C/EBPalpha-negative human hepatocellular carcinoma HLF cells, however, did not influence the rate of cell proliferation or cell cycle. Our present data suggest that the expression of the C/EBPalpha gene was downregulated in the majority of human hepatocellular carcinoma but the expression may not be directly associated with impaired proliferative activity of hepatocellular carcinoma cells.

Authors+Show Affiliations

Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba City 260-8670, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12011976

Citation

Tomizawa, Minoru, et al. "Decreased Expression of the CCAAT/enhancer Binding Protein Alpha Gene Involved in Hepatocyte Proliferation in Human Hepatocellular Carcinomas." International Journal of Molecular Medicine, vol. 9, no. 6, 2002, pp. 597-600.
Tomizawa M, Wang YQ, Ebara M, et al. Decreased expression of the CCAAT/enhancer binding protein alpha gene involved in hepatocyte proliferation in human hepatocellular carcinomas. Int J Mol Med. 2002;9(6):597-600.
Tomizawa, M., Wang, Y. Q., Ebara, M., Saisho, H., Watanabe, K., Nakagawara, A., & Tagawa, M. (2002). Decreased expression of the CCAAT/enhancer binding protein alpha gene involved in hepatocyte proliferation in human hepatocellular carcinomas. International Journal of Molecular Medicine, 9(6), 597-600.
Tomizawa M, et al. Decreased Expression of the CCAAT/enhancer Binding Protein Alpha Gene Involved in Hepatocyte Proliferation in Human Hepatocellular Carcinomas. Int J Mol Med. 2002;9(6):597-600. PubMed PMID: 12011976.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Decreased expression of the CCAAT/enhancer binding protein alpha gene involved in hepatocyte proliferation in human hepatocellular carcinomas. AU - Tomizawa,Minoru, AU - Wang,Yan-Qing, AU - Ebara,Masaaki, AU - Saisho,Hiromitsu, AU - Watanabe,Kazuo, AU - Nakagawara,Akira, AU - Tagawa,Masatoshi, PY - 2002/5/16/pubmed PY - 2002/8/31/medline PY - 2002/5/16/entrez SP - 597 EP - 600 JF - International journal of molecular medicine JO - Int J Mol Med VL - 9 IS - 6 N2 - CCAAT/enhancer binding protein alpha (C/EBPalpha), expressed at a high level in liver, plays an important role in proliferation and differentiation of hepatocytes. Previous studies showed that an expression level of the C/EBPalpha gene in hepatocytes was downregulated in response to proliferation signals and that forced expression of the C/EBPalpha gene in a number of cells caused cell cycle arrest. We compared the expression level of the C/EBPalpha gene in surgical specimens between hepatocellular carcinoma and non-tumorous regions of the same patients. In 9 out of 13 cases, the expression level in the tumors was decreased compared with that in corresponding non-tumorous regions. Transfection of the C/EBPalpha gene into C/EBPalpha-negative human hepatocellular carcinoma HLF cells, however, did not influence the rate of cell proliferation or cell cycle. Our present data suggest that the expression of the C/EBPalpha gene was downregulated in the majority of human hepatocellular carcinoma but the expression may not be directly associated with impaired proliferative activity of hepatocellular carcinoma cells. SN - 1107-3756 UR - https://www.unboundmedicine.com/medline/citation/12011976/Decreased_expression_of_the_CCAAT/enhancer_binding_protein_alpha_gene_involved_in_hepatocyte_proliferation_in_human_hepatocellular_carcinomas_ L2 - https://www.spandidos-publications.com/ijmm/9/6/597 DB - PRIME DP - Unbound Medicine ER -