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Occurrence of osteopenia among adolescent girls with oligo/amenorrhea.
Gynecol Endocrinol. 2002 Apr; 16(2):99-105.GE

Abstract

The occurrence of reduced bone mineral density (BMD) among adolescent girls with oligomenorrhea or secondary amenorrhea, due to 'pure' dysfunction of the hypothalamo-pituitary-ovarian (HPO) axis (without anorexia nervosa, excessive sport or ballet, slimming diet, etc.) was examined. The study group consisted of 19 adolescent girls (age 16-18 years) with oligo/amenorrhea. Clinical (height, weight, age at menarche, duration of amenorrhea, body mass index (BMI)), hormonal (follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol, progesterone, testosterone, prolactin), and ion (calcium, sodium, potassium, phosphate, chloride) parameters and the BMD of the lumbar spine were investigated. Correlations between BMD and other parameters were also examined. Twenty healthy volunteers (same age and regular cycles) served as controls. Three girls had osteoporosis, with a BMD below -2 standard deviations (SD). Ten showed osteopenia, with a BMD value between -1 and -2 SD. Only six of the study group had a normal BMD within +/- 1 SD. A positive correlation was observed between the BMD and the BMI (r = 0.73; p < 0.05). All the controls had normal hormonal, ion and BMD parameters. 'Pure' dysfunction of the HPO axis in adolescents, causing oligomenorrhea or secondary amenorrhea, might result in reduced BMD and, consequently, lower peak bone mass. Treatment of menstrual cycle disorders is necessary for the prevention of osteoporosis.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Faculty of Medicine, University of Pécs, H-7624 Pécs, Edesanyák útja 17, Hungary.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12012630

Citation

Csermely, T, et al. "Occurrence of Osteopenia Among Adolescent Girls With Oligo/amenorrhea." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 16, no. 2, 2002, pp. 99-105.
Csermely T, Halvax L, Schmidt E, et al. Occurrence of osteopenia among adolescent girls with oligo/amenorrhea. Gynecol Endocrinol. 2002;16(2):99-105.
Csermely, T., Halvax, L., Schmidt, E., Zámbó, K., Vadon, G., Szabó, I., & Szilágyi, A. (2002). Occurrence of osteopenia among adolescent girls with oligo/amenorrhea. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 16(2), 99-105.
Csermely T, et al. Occurrence of Osteopenia Among Adolescent Girls With Oligo/amenorrhea. Gynecol Endocrinol. 2002;16(2):99-105. PubMed PMID: 12012630.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Occurrence of osteopenia among adolescent girls with oligo/amenorrhea. AU - Csermely,T, AU - Halvax,L, AU - Schmidt,E, AU - Zámbó,K, AU - Vadon,G, AU - Szabó,I, AU - Szilágyi,A, PY - 2002/5/16/pubmed PY - 2002/11/26/medline PY - 2002/5/16/entrez SP - 99 EP - 105 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol Endocrinol VL - 16 IS - 2 N2 - The occurrence of reduced bone mineral density (BMD) among adolescent girls with oligomenorrhea or secondary amenorrhea, due to 'pure' dysfunction of the hypothalamo-pituitary-ovarian (HPO) axis (without anorexia nervosa, excessive sport or ballet, slimming diet, etc.) was examined. The study group consisted of 19 adolescent girls (age 16-18 years) with oligo/amenorrhea. Clinical (height, weight, age at menarche, duration of amenorrhea, body mass index (BMI)), hormonal (follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol, progesterone, testosterone, prolactin), and ion (calcium, sodium, potassium, phosphate, chloride) parameters and the BMD of the lumbar spine were investigated. Correlations between BMD and other parameters were also examined. Twenty healthy volunteers (same age and regular cycles) served as controls. Three girls had osteoporosis, with a BMD below -2 standard deviations (SD). Ten showed osteopenia, with a BMD value between -1 and -2 SD. Only six of the study group had a normal BMD within +/- 1 SD. A positive correlation was observed between the BMD and the BMI (r = 0.73; p < 0.05). All the controls had normal hormonal, ion and BMD parameters. 'Pure' dysfunction of the HPO axis in adolescents, causing oligomenorrhea or secondary amenorrhea, might result in reduced BMD and, consequently, lower peak bone mass. Treatment of menstrual cycle disorders is necessary for the prevention of osteoporosis. SN - 0951-3590 UR - https://www.unboundmedicine.com/medline/citation/12012630/Occurrence_of_osteopenia_among_adolescent_girls_with_oligo/amenorrhea_ DB - PRIME DP - Unbound Medicine ER -