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Serum colloidal osmotic pressure in the development of kwashiorkor and in recovery: its relationship to albumin and globulin concentrations and oedema.
Br J Nutr 1975; 34(3):459-67BJ

Abstract

1. Serum colloidal osmotic pressure was measured in children 'at risk' to kwashiorkor, in other with frank signs of the disease and during recovery. Simultaneous estimations of serum albumin and globulin concentrations and assessments of the extent of oedema were also made. 2. During the development of kwashiorkor, serum colloidal osmotic pressure did not decrease significantly until albumin concentration was 25-1--27-5 g/l. Above 30-0 g/1, colloidal osmotic pressure was maintained at normal levels during which time a significant reciprocal relationship existed between albumin and globulin concentrations. These findings provide support for suggestions that there may be on oncotic regulation of albumin synthesis. 3. Low albumin concentrations were mainly responsible for the low colloidal osmotic pressures found in children with kwashiorkor and in agreement and previous findings the threshold for the formation of oncotic oedema was found to be about 2-35--2-65 kN/m2. 4. Values for colloidal osmotic pressure calculated from serum albumin and gobulin concentrations using emprical formulas did not agree well with measured values and no constant correction factor suitable over the whole range of albumin concentrations found in rural Ugandan children could be devised. In many hypoalbuminaemic children ony direct measurement of serum colloidal pressure will indicate the true extent of risk to an episode of oedema.

Authors

No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1201269

Citation

Coward, W A.. "Serum Colloidal Osmotic Pressure in the Development of Kwashiorkor and in Recovery: Its Relationship to Albumin and Globulin Concentrations and Oedema." The British Journal of Nutrition, vol. 34, no. 3, 1975, pp. 459-67.
Coward WA. Serum colloidal osmotic pressure in the development of kwashiorkor and in recovery: its relationship to albumin and globulin concentrations and oedema. Br J Nutr. 1975;34(3):459-67.
Coward, W. A. (1975). Serum colloidal osmotic pressure in the development of kwashiorkor and in recovery: its relationship to albumin and globulin concentrations and oedema. The British Journal of Nutrition, 34(3), pp. 459-67.
Coward WA. Serum Colloidal Osmotic Pressure in the Development of Kwashiorkor and in Recovery: Its Relationship to Albumin and Globulin Concentrations and Oedema. Br J Nutr. 1975;34(3):459-67. PubMed PMID: 1201269.
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TY - JOUR T1 - Serum colloidal osmotic pressure in the development of kwashiorkor and in recovery: its relationship to albumin and globulin concentrations and oedema. A1 - Coward,W A, PY - 1975/11/1/pubmed PY - 1975/11/1/medline PY - 1975/11/1/entrez SP - 459 EP - 67 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 34 IS - 3 N2 - 1. Serum colloidal osmotic pressure was measured in children 'at risk' to kwashiorkor, in other with frank signs of the disease and during recovery. Simultaneous estimations of serum albumin and globulin concentrations and assessments of the extent of oedema were also made. 2. During the development of kwashiorkor, serum colloidal osmotic pressure did not decrease significantly until albumin concentration was 25-1--27-5 g/l. Above 30-0 g/1, colloidal osmotic pressure was maintained at normal levels during which time a significant reciprocal relationship existed between albumin and globulin concentrations. These findings provide support for suggestions that there may be on oncotic regulation of albumin synthesis. 3. Low albumin concentrations were mainly responsible for the low colloidal osmotic pressures found in children with kwashiorkor and in agreement and previous findings the threshold for the formation of oncotic oedema was found to be about 2-35--2-65 kN/m2. 4. Values for colloidal osmotic pressure calculated from serum albumin and gobulin concentrations using emprical formulas did not agree well with measured values and no constant correction factor suitable over the whole range of albumin concentrations found in rural Ugandan children could be devised. In many hypoalbuminaemic children ony direct measurement of serum colloidal pressure will indicate the true extent of risk to an episode of oedema. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/1201269/Serum_colloidal_osmotic_pressure_in_the_development_of_kwashiorkor_and_in_recovery:_its_relationship_to_albumin_and_globulin_concentrations_and_oedema_ L2 - https://medlineplus.gov/edema.html DB - PRIME DP - Unbound Medicine ER -