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Use of prick-tests in the screening of immediate allergy to protein: 16 cases.

Abstract

BACKGROUND

Allergy to protein hydrolysates seem to be on the rise but screening is difficult because of the wide range of symptoms. The goal of our study was to improve the screening process by skin prick testing infants with an anaphylactic form of allergy to cow's milk.

METHODS

We studied 92 infants who were allergic to cow's milk. The diagnosis was based on the results of skin prick tests, specific IgE assays, and oral food challenges. The skin prick tests were performed using a number of protein hydrolysate formulae and a synthetic amino acid-based formula available in France.

RESULTS

We detected sensitisation to the hydrolysates in 16 infants (17.3%), 15 by positive skin prick tests and one due to persistent symptoms on protein hydrolysate formulae (gastrointestinal manifestations, atopic dermatitis, and multiple food allergies), which completely receded when the synthetic amino acid formula was used as a substitute. Two infants had a positive hydrolysate oral food challenge test. There were no statistically significant differences in terms of age, sex, breastfeeding, clinical manifestations, family history, skin reaction size, or associated allergies. The infants who were sensitised to the hydrolysates had significantly higher specific IgE levels (whole milk,(_)-lactalbumin, and casein; median = 25.6 kU/L for cow's milk, p = 0.03) than those who were allergic to cow's milk but not sensitised to the hydrolysates.

CONCLUSIONS

Skin prick tests can be used to screen for sensitisation to hydrolysates in infants with IgE-mediated cow's milk allergy. They can also be used to determine the most suitable hydrolysate formula for individual infants.

Authors+Show Affiliations

,

Hôpital des Enfants, CHU Toulouse, 31026 Toulouse, France.

,

Source

Allergie et immunologie 34:3 2002 Mar pg 71-6

MeSH

Administration, Oral
Allergens
Amino Acids
Animals
Breast Feeding
Butter
Caseins
Cattle
Dermatitis, Atopic
Double-Blind Method
Female
Gastrointestinal Diseases
Humans
Hydrolysis
Hypersensitivity, Immediate
Immunoglobulin E
Infant
Infant Food
Lactalbumin
Male
Mass Screening
Milk Hypersensitivity
Respiratory Hypersensitivity
Skin Tests

Pub Type(s)

Comparative Study
Evaluation Studies
Journal Article

Language

eng

PubMed ID

12012790

Citation

Rancé, F, et al. "Use of Prick-tests in the Screening of Immediate Allergy to Protein: 16 Cases." Allergie Et Immunologie, vol. 34, no. 3, 2002, pp. 71-6.
Rancé F, Brondeau V, Abbal M. Use of prick-tests in the screening of immediate allergy to protein: 16 cases. Allerg Immunol (Paris). 2002;34(3):71-6.
Rancé, F., Brondeau, V., & Abbal, M. (2002). Use of prick-tests in the screening of immediate allergy to protein: 16 cases. Allergie Et Immunologie, 34(3), pp. 71-6.
Rancé F, Brondeau V, Abbal M. Use of Prick-tests in the Screening of Immediate Allergy to Protein: 16 Cases. Allerg Immunol (Paris). 2002;34(3):71-6. PubMed PMID: 12012790.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Use of prick-tests in the screening of immediate allergy to protein: 16 cases. AU - Rancé,F, AU - Brondeau,V, AU - Abbal,M, PY - 2002/5/16/pubmed PY - 2002/7/13/medline PY - 2002/5/16/entrez SP - 71 EP - 6 JF - Allergie et immunologie JO - Allerg Immunol (Paris) VL - 34 IS - 3 N2 - BACKGROUND: Allergy to protein hydrolysates seem to be on the rise but screening is difficult because of the wide range of symptoms. The goal of our study was to improve the screening process by skin prick testing infants with an anaphylactic form of allergy to cow's milk. METHODS: We studied 92 infants who were allergic to cow's milk. The diagnosis was based on the results of skin prick tests, specific IgE assays, and oral food challenges. The skin prick tests were performed using a number of protein hydrolysate formulae and a synthetic amino acid-based formula available in France. RESULTS: We detected sensitisation to the hydrolysates in 16 infants (17.3%), 15 by positive skin prick tests and one due to persistent symptoms on protein hydrolysate formulae (gastrointestinal manifestations, atopic dermatitis, and multiple food allergies), which completely receded when the synthetic amino acid formula was used as a substitute. Two infants had a positive hydrolysate oral food challenge test. There were no statistically significant differences in terms of age, sex, breastfeeding, clinical manifestations, family history, skin reaction size, or associated allergies. The infants who were sensitised to the hydrolysates had significantly higher specific IgE levels (whole milk,(_)-lactalbumin, and casein; median = 25.6 kU/L for cow's milk, p = 0.03) than those who were allergic to cow's milk but not sensitised to the hydrolysates. CONCLUSIONS: Skin prick tests can be used to screen for sensitisation to hydrolysates in infants with IgE-mediated cow's milk allergy. They can also be used to determine the most suitable hydrolysate formula for individual infants. SN - 0397-9148 UR - https://www.unboundmedicine.com/medline/citation/12012790/Use_of_prick_tests_in_the_screening_of_immediate_allergy_to_protein:_16_cases_ L2 - https://medlineplus.gov/infantandnewbornnutrition.html DB - PRIME DP - Unbound Medicine ER -