Tags

Type your tag names separated by a space and hit enter

New classification of pancreatic intraductal papillary-mucinous tumour by mucin expression: its relationship with potential for malignancy.
J Pathol 2002; 197(2):201-10JP

Abstract

In previous studies of the expression of MUC1 (membrane-bound type mucin) and MUC2 (intestinal type secretory mucin) in pancreatic tumours, invasive ductal carcinoma (IDC) usually showed MUC1+ and MUC2- expression, whereas intraductal papillary-mucinous tumour (IPMT) showed MUC1- and MUC2+ expression. Recently, however, many IPMTs have been collected, a considerable number of which have shown MUC1- and MUC2- expression. In the present study, the clinicopathological features were examined of 18 IPMTs with MUC2+ and 32 IPMTs with MUC2-, and their potential for malignancy was compared. Most of the IPMTs with MUC2+ were composed of dark columnar cells, whereas most of the IPMTs with MUC2- were composed of clear columnar cells. The incidence of carcinomatous change and invasive proliferation of the carcinoma in the MUC2+ tumours was significantly higher than in the MUC2- tumours. The clinical outcome for the patients with IPMT showing the MUC2+ pattern tended to be worse than for those with IPMT showing the MUC2- pattern, although the overall outcome for the two types of IPMT was significantly better than for those with IDC. Because of the differences in mucin expression pattern, morphological appearance and potential for malignancy between the two types of IPMT, we believe that they belong to different neoplastic lineages and that it may be reasonable to classify them as different entities, although the WHO classification contains a single clinicopathological entity of IPMT forming an adenoma-carcinoma sequence. In conclusion, our classification of IPMTs by MUC2 expression pattern may be of value in the better assessment of the biological behaviour of IPMTs and their potential for malignancy.

Authors+Show Affiliations

Department of Pathology, Kagoshima University Faculty of Medicine, Sakuragaoka, Kagoshima, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12015744

Citation

Nakamura, Akiko, et al. "New Classification of Pancreatic Intraductal Papillary-mucinous Tumour By Mucin Expression: Its Relationship With Potential for Malignancy." The Journal of Pathology, vol. 197, no. 2, 2002, pp. 201-10.
Nakamura A, Horinouchi M, Goto M, et al. New classification of pancreatic intraductal papillary-mucinous tumour by mucin expression: its relationship with potential for malignancy. J Pathol. 2002;197(2):201-10.
Nakamura, A., Horinouchi, M., Goto, M., Nagata, K., Sakoda, K., Takao, S., ... Yonezawa, S. (2002). New classification of pancreatic intraductal papillary-mucinous tumour by mucin expression: its relationship with potential for malignancy. The Journal of Pathology, 197(2), pp. 201-10.
Nakamura A, et al. New Classification of Pancreatic Intraductal Papillary-mucinous Tumour By Mucin Expression: Its Relationship With Potential for Malignancy. J Pathol. 2002;197(2):201-10. PubMed PMID: 12015744.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - New classification of pancreatic intraductal papillary-mucinous tumour by mucin expression: its relationship with potential for malignancy. AU - Nakamura,Akiko, AU - Horinouchi,Michiko, AU - Goto,Masamichi, AU - Nagata,Kohji, AU - Sakoda,Koro, AU - Takao,Sonshin, AU - Imai,Kohzoh, AU - Kim,Young S, AU - Sato,Eiichi, AU - Yonezawa,Suguru, PY - 2002/5/17/pubmed PY - 2002/7/2/medline PY - 2002/5/17/entrez SP - 201 EP - 10 JF - The Journal of pathology JO - J. Pathol. VL - 197 IS - 2 N2 - In previous studies of the expression of MUC1 (membrane-bound type mucin) and MUC2 (intestinal type secretory mucin) in pancreatic tumours, invasive ductal carcinoma (IDC) usually showed MUC1+ and MUC2- expression, whereas intraductal papillary-mucinous tumour (IPMT) showed MUC1- and MUC2+ expression. Recently, however, many IPMTs have been collected, a considerable number of which have shown MUC1- and MUC2- expression. In the present study, the clinicopathological features were examined of 18 IPMTs with MUC2+ and 32 IPMTs with MUC2-, and their potential for malignancy was compared. Most of the IPMTs with MUC2+ were composed of dark columnar cells, whereas most of the IPMTs with MUC2- were composed of clear columnar cells. The incidence of carcinomatous change and invasive proliferation of the carcinoma in the MUC2+ tumours was significantly higher than in the MUC2- tumours. The clinical outcome for the patients with IPMT showing the MUC2+ pattern tended to be worse than for those with IPMT showing the MUC2- pattern, although the overall outcome for the two types of IPMT was significantly better than for those with IDC. Because of the differences in mucin expression pattern, morphological appearance and potential for malignancy between the two types of IPMT, we believe that they belong to different neoplastic lineages and that it may be reasonable to classify them as different entities, although the WHO classification contains a single clinicopathological entity of IPMT forming an adenoma-carcinoma sequence. In conclusion, our classification of IPMTs by MUC2 expression pattern may be of value in the better assessment of the biological behaviour of IPMTs and their potential for malignancy. SN - 0022-3417 UR - https://www.unboundmedicine.com/medline/citation/12015744/New_classification_of_pancreatic_intraductal_papillary_mucinous_tumour_by_mucin_expression:_its_relationship_with_potential_for_malignancy_ L2 - https://doi.org/10.1002/path.1109 DB - PRIME DP - Unbound Medicine ER -