Tags

Type your tag names separated by a space and hit enter

High frequency of microsatellite instability and loss of mismatch-repair protein expression in patients with double primary tumors of the endometrium and colorectum.
Cancer. 2002 May 01; 94(9):2502-10.C

Abstract

BACKGROUND

Patients with the familial syndrome hereditary nonpolyposis colorectal carcinoma (HNPCC) exhibit an increased risk for several tumor types, of which the greatest lifetime risk is for colorectal and endometrial carcinoma. HNPCC is caused by a germline mutation in one of several identified mismatch repair (MMR) genes and typically presents with microsatellite instability (MSI) and frequent loss of MMR protein expression in the tumor tissue. The objective of this study was to estimate the proportion of double primary tumors of the endometrium and colorectum that displays tumor characteristics suggestive of MMR deficiency.

METHODS

The authors used the southern Sweden regional population-based Cancer Registry to identify women who developed double primary tumors of the endometrium and colorectum. Of the 256 women who were diagnosed with carcinoma at both of these sites during the period 1958-1998, 39 women had developed their first tumor before age 50 years. The authors successfully retrieved 67 tumors from 36 of these patients and analyzed them for MSI and immunohistochemical expression of the MMR genes, MLH1, MSH2, and MSH6.

RESULTS

The MSI status of the 67 tumors was high MSI in 37 tumors, low MSI in 13 tumors, and microsatellite stable (MSS) in 17 tumors. Immunohistochemical loss of MMR protein expression was correlated with MSI status and was demonstrated in 29 high MSI tumors, in 1 low MSI tumor, and in 1 MSS tumor. A concordant loss of the same MMR protein in both tumors was found in 12 of 27 patients.

CONCLUSIONS

The authors demonstrated a high frequency of MSI (75%) in tumors from women with endometrial and colorectal carcinoma who had their first tumor diagnosed before age 50 years and observed concordant immunohistochemical loss of MMR protein expression, suggestive of a possible underlying germline mutation, in 12 of 27 patients (44%). They concluded that double primary malignancies of the colorectum and endometrium at a young age should make the clinician suspect HNPCC.

Authors+Show Affiliations

Department of Oncology, the Jubileum Institution, University Hospital, Lund, Sweden. maria.planck@onk.lu.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12015776

Citation

Planck, Maria, et al. "High Frequency of Microsatellite Instability and Loss of Mismatch-repair Protein Expression in Patients With Double Primary Tumors of the Endometrium and Colorectum." Cancer, vol. 94, no. 9, 2002, pp. 2502-10.
Planck M, Rambech E, Möslein G, et al. High frequency of microsatellite instability and loss of mismatch-repair protein expression in patients with double primary tumors of the endometrium and colorectum. Cancer. 2002;94(9):2502-10.
Planck, M., Rambech, E., Möslein, G., Müller, W., Olsson, H., & Nilbert, M. (2002). High frequency of microsatellite instability and loss of mismatch-repair protein expression in patients with double primary tumors of the endometrium and colorectum. Cancer, 94(9), 2502-10.
Planck M, et al. High Frequency of Microsatellite Instability and Loss of Mismatch-repair Protein Expression in Patients With Double Primary Tumors of the Endometrium and Colorectum. Cancer. 2002 May 1;94(9):2502-10. PubMed PMID: 12015776.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High frequency of microsatellite instability and loss of mismatch-repair protein expression in patients with double primary tumors of the endometrium and colorectum. AU - Planck,Maria, AU - Rambech,Eva, AU - Möslein,Gabriela, AU - Müller,Wolfram, AU - Olsson,Håkan, AU - Nilbert,Mef, PY - 2002/5/17/pubmed PY - 2002/6/14/medline PY - 2002/5/17/entrez SP - 2502 EP - 10 JF - Cancer JO - Cancer VL - 94 IS - 9 N2 - BACKGROUND: Patients with the familial syndrome hereditary nonpolyposis colorectal carcinoma (HNPCC) exhibit an increased risk for several tumor types, of which the greatest lifetime risk is for colorectal and endometrial carcinoma. HNPCC is caused by a germline mutation in one of several identified mismatch repair (MMR) genes and typically presents with microsatellite instability (MSI) and frequent loss of MMR protein expression in the tumor tissue. The objective of this study was to estimate the proportion of double primary tumors of the endometrium and colorectum that displays tumor characteristics suggestive of MMR deficiency. METHODS: The authors used the southern Sweden regional population-based Cancer Registry to identify women who developed double primary tumors of the endometrium and colorectum. Of the 256 women who were diagnosed with carcinoma at both of these sites during the period 1958-1998, 39 women had developed their first tumor before age 50 years. The authors successfully retrieved 67 tumors from 36 of these patients and analyzed them for MSI and immunohistochemical expression of the MMR genes, MLH1, MSH2, and MSH6. RESULTS: The MSI status of the 67 tumors was high MSI in 37 tumors, low MSI in 13 tumors, and microsatellite stable (MSS) in 17 tumors. Immunohistochemical loss of MMR protein expression was correlated with MSI status and was demonstrated in 29 high MSI tumors, in 1 low MSI tumor, and in 1 MSS tumor. A concordant loss of the same MMR protein in both tumors was found in 12 of 27 patients. CONCLUSIONS: The authors demonstrated a high frequency of MSI (75%) in tumors from women with endometrial and colorectal carcinoma who had their first tumor diagnosed before age 50 years and observed concordant immunohistochemical loss of MMR protein expression, suggestive of a possible underlying germline mutation, in 12 of 27 patients (44%). They concluded that double primary malignancies of the colorectum and endometrium at a young age should make the clinician suspect HNPCC. SN - 0008-543X UR - https://www.unboundmedicine.com/medline/citation/12015776/High_frequency_of_microsatellite_instability_and_loss_of_mismatch_repair_protein_expression_in_patients_with_double_primary_tumors_of_the_endometrium_and_colorectum_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0008-543X&date=2002&volume=94&issue=9&spage=2502 DB - PRIME DP - Unbound Medicine ER -