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A heat-sensitive TRP channel expressed in keratinocytes.
Science. 2002 Jun 14; 296(5575):2046-9.Sci

Abstract

Mechanical and thermal cues stimulate a specialized group of sensory neurons that terminate in the skin. Three members of the transient receptor potential (TRP) family of channels are expressed in subsets of these neurons and are activated at distinct physiological temperatures. Here, we describe the cloning and characterization of a novel thermosensitive TRP channel. TRPV3 has a unique threshold: It is activated at innocuous (warm) temperatures and shows an increased response at noxious temperatures. TRPV3 is specifically expressed in keratinocytes; hence, skin cells are capable of detecting heat via molecules similar to those in heat-sensing neurons.

Authors+Show Affiliations

Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12016205

Citation

Peier, Andrea M., et al. "A Heat-sensitive TRP Channel Expressed in Keratinocytes." Science (New York, N.Y.), vol. 296, no. 5575, 2002, pp. 2046-9.
Peier AM, Reeve AJ, Andersson DA, et al. A heat-sensitive TRP channel expressed in keratinocytes. Science. 2002;296(5575):2046-9.
Peier, A. M., Reeve, A. J., Andersson, D. A., Moqrich, A., Earley, T. J., Hergarden, A. C., Story, G. M., Colley, S., Hogenesch, J. B., McIntyre, P., Bevan, S., & Patapoutian, A. (2002). A heat-sensitive TRP channel expressed in keratinocytes. Science (New York, N.Y.), 296(5575), 2046-9.
Peier AM, et al. A Heat-sensitive TRP Channel Expressed in Keratinocytes. Science. 2002 Jun 14;296(5575):2046-9. PubMed PMID: 12016205.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A heat-sensitive TRP channel expressed in keratinocytes. AU - Peier,Andrea M, AU - Reeve,Alison J, AU - Andersson,David A, AU - Moqrich,Aziz, AU - Earley,Taryn J, AU - Hergarden,Anne C, AU - Story,Gina M, AU - Colley,Sian, AU - Hogenesch,John B, AU - McIntyre,Peter, AU - Bevan,Stuart, AU - Patapoutian,Ardem, Y1 - 2002/05/16/ PY - 2002/5/23/pubmed PY - 2002/7/16/medline PY - 2002/5/23/entrez SP - 2046 EP - 9 JF - Science (New York, N.Y.) JO - Science VL - 296 IS - 5575 N2 - Mechanical and thermal cues stimulate a specialized group of sensory neurons that terminate in the skin. Three members of the transient receptor potential (TRP) family of channels are expressed in subsets of these neurons and are activated at distinct physiological temperatures. Here, we describe the cloning and characterization of a novel thermosensitive TRP channel. TRPV3 has a unique threshold: It is activated at innocuous (warm) temperatures and shows an increased response at noxious temperatures. TRPV3 is specifically expressed in keratinocytes; hence, skin cells are capable of detecting heat via molecules similar to those in heat-sensing neurons. SN - 1095-9203 UR - https://www.unboundmedicine.com/medline/citation/12016205/A_heat_sensitive_TRP_channel_expressed_in_keratinocytes_ L2 - http://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=12016205 DB - PRIME DP - Unbound Medicine ER -