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[Apolipoprotein E polymorphism and plasma lipid, lipoprotein, apolipoprotein levels in 291 children of Changsha].
Hunan Yi Ke Da Xue Xue Bao. 1999; 24(3):232-6.HY

Abstract

In order to investigate the distribution of apolipoprotein (Apo) E polymorphism and effect of ApoE genotypes on plasma lipid, lipoprotein, apolipoprotein levels in children of Changsha, we determined ApoE genotypes in 291 children by means of PCR-RFLP. ApoE allele frequencies in the population were epsilon 2 = 0.081, epsilon 3 = 0.857, epsilon 4 = 0.062. There were no difference in the ApoE genotypes distribution between sexes. The children with Apo epsilon 2 allele had higher levels of ApoE, ApoA1 and high density lipoprotein-cholesterol together with lower levels of total cholesterol, ApoB100 and low density lipoprotein-cholesterol than those with other ApoE alleles. These changes were opposite in children with Apo epsilon 4 allele. The levels of plasma triglyceride, lipoprotein(a) were not affected significantly by ApoE alleles. Moreover, the effect of ApoE genotypes on levels of plasma lipids was different between sexes. These results suggest that ApoE polymorphisms could affect plasma lipids metabolism in children.

Authors+Show Affiliations

Department of Pediatrics, Second Affiliated Hospital, Hunan Medical University, Changsha 410011.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

12016791

Citation

Xiang, W, et al. "[Apolipoprotein E Polymorphism and Plasma Lipid, Lipoprotein, Apolipoprotein Levels in 291 Children of Changsha]." Hunan Yi Ke Da Xue Xue Bao = Hunan Yike Daxue Xuebao = Bulletin of Hunan Medical University, vol. 24, no. 3, 1999, pp. 232-6.
Xiang W, Zhao S, Peng D. [Apolipoprotein E polymorphism and plasma lipid, lipoprotein, apolipoprotein levels in 291 children of Changsha]. Hunan Yi Ke Da Xue Xue Bao. 1999;24(3):232-6.
Xiang, W., Zhao, S., & Peng, D. (1999). [Apolipoprotein E polymorphism and plasma lipid, lipoprotein, apolipoprotein levels in 291 children of Changsha]. Hunan Yi Ke Da Xue Xue Bao = Hunan Yike Daxue Xuebao = Bulletin of Hunan Medical University, 24(3), 232-6.
Xiang W, Zhao S, Peng D. [Apolipoprotein E Polymorphism and Plasma Lipid, Lipoprotein, Apolipoprotein Levels in 291 Children of Changsha]. Hunan Yi Ke Da Xue Xue Bao. 1999;24(3):232-6. PubMed PMID: 12016791.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Apolipoprotein E polymorphism and plasma lipid, lipoprotein, apolipoprotein levels in 291 children of Changsha]. AU - Xiang,W, AU - Zhao,S, AU - Peng,D, PY - 2002/5/23/pubmed PY - 2002/7/31/medline PY - 2002/5/23/entrez SP - 232 EP - 6 JF - Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University JO - Hunan Yi Ke Da Xue Xue Bao VL - 24 IS - 3 N2 - In order to investigate the distribution of apolipoprotein (Apo) E polymorphism and effect of ApoE genotypes on plasma lipid, lipoprotein, apolipoprotein levels in children of Changsha, we determined ApoE genotypes in 291 children by means of PCR-RFLP. ApoE allele frequencies in the population were epsilon 2 = 0.081, epsilon 3 = 0.857, epsilon 4 = 0.062. There were no difference in the ApoE genotypes distribution between sexes. The children with Apo epsilon 2 allele had higher levels of ApoE, ApoA1 and high density lipoprotein-cholesterol together with lower levels of total cholesterol, ApoB100 and low density lipoprotein-cholesterol than those with other ApoE alleles. These changes were opposite in children with Apo epsilon 4 allele. The levels of plasma triglyceride, lipoprotein(a) were not affected significantly by ApoE alleles. Moreover, the effect of ApoE genotypes on levels of plasma lipids was different between sexes. These results suggest that ApoE polymorphisms could affect plasma lipids metabolism in children. SN - 1000-5625 UR - https://www.unboundmedicine.com/medline/citation/12016791/[Apolipoprotein_E_polymorphism_and_plasma_lipid_lipoprotein_apolipoprotein_levels_in_291_children_of_Changsha]_ DB - PRIME DP - Unbound Medicine ER -