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A prospective cohort study of cigarette smoking and pancreatic cancer in Japan.
Cancer Causes Control 2002; 13(3):249-54CC

Abstract

OBJECTIVE

To examine the association of cigarette smoking with the risk of death from pancreatic cancer in a prospective cohort study.

METHODS

A total of 110,792 inhabitants, aged 40-79 years (46,465 men and 64,327 women), were enrolled from 1988 to 1990 and followed up for mortality to the end of 1997. At baseline a self-administered questionnaire was used to obtain information on cigarette smoking and other lifestyle factors.

RESULTS

During the follow-up period (mean +/- SD: 8.1 +/- 1.8 years), 225 deaths due to pancreatic cancer were identified. After adjustment for age, body mass index, history of diabetes mellitus, and gallbladder diseases, the relative risks (RRs) for current smokers were 1.6 (95% CI 0.95-2.6) in males, and 1.7 (95% CI: 0.84-3.3) in females. Men who smoked more than 40 cigarettes per day had a substantially higher risk of pancreatic cancer, with a RR of 3.3 (95% CI: 1.4-8.1). A significantly decreasing trend in risk with increasing years after smoking cessation was observed (trend p = 0.04) among male ex-smokers. The RRs were 0.85 (95% CI 0.36-2.0) and 0.85 (0.36-2.0) for those who had quit smoking for 10-19 and > or =20 years, respectively.

CONCLUSIONS

Our cohort study confirmed that cigarette smoking was associated with an increased risk of death from pancreatic cancer.

Authors+Show Affiliations

Department of Public Health, Aichi Medical University School of Medicine, Aichi Prefecture, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12020106

Citation

Lin, Yingsong, et al. "A Prospective Cohort Study of Cigarette Smoking and Pancreatic Cancer in Japan." Cancer Causes & Control : CCC, vol. 13, no. 3, 2002, pp. 249-54.
Lin Y, Tamakoshi A, Kawamura T, et al. A prospective cohort study of cigarette smoking and pancreatic cancer in Japan. Cancer Causes Control. 2002;13(3):249-54.
Lin, Y., Tamakoshi, A., Kawamura, T., Inaba, Y., Kikuchi, S., Motohashi, Y., & Kurosawa, M. (2002). A prospective cohort study of cigarette smoking and pancreatic cancer in Japan. Cancer Causes & Control : CCC, 13(3), pp. 249-54.
Lin Y, et al. A Prospective Cohort Study of Cigarette Smoking and Pancreatic Cancer in Japan. Cancer Causes Control. 2002;13(3):249-54. PubMed PMID: 12020106.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A prospective cohort study of cigarette smoking and pancreatic cancer in Japan. AU - Lin,Yingsong, AU - Tamakoshi,Akiko, AU - Kawamura,Takashi, AU - Inaba,Yutaka, AU - Kikuchi,Shogo, AU - Motohashi,Yutaka, AU - Kurosawa,Michiko, AU - ,, PY - 2002/5/22/pubmed PY - 2002/11/26/medline PY - 2002/5/22/entrez SP - 249 EP - 54 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 13 IS - 3 N2 - OBJECTIVE: To examine the association of cigarette smoking with the risk of death from pancreatic cancer in a prospective cohort study. METHODS: A total of 110,792 inhabitants, aged 40-79 years (46,465 men and 64,327 women), were enrolled from 1988 to 1990 and followed up for mortality to the end of 1997. At baseline a self-administered questionnaire was used to obtain information on cigarette smoking and other lifestyle factors. RESULTS: During the follow-up period (mean +/- SD: 8.1 +/- 1.8 years), 225 deaths due to pancreatic cancer were identified. After adjustment for age, body mass index, history of diabetes mellitus, and gallbladder diseases, the relative risks (RRs) for current smokers were 1.6 (95% CI 0.95-2.6) in males, and 1.7 (95% CI: 0.84-3.3) in females. Men who smoked more than 40 cigarettes per day had a substantially higher risk of pancreatic cancer, with a RR of 3.3 (95% CI: 1.4-8.1). A significantly decreasing trend in risk with increasing years after smoking cessation was observed (trend p = 0.04) among male ex-smokers. The RRs were 0.85 (95% CI 0.36-2.0) and 0.85 (0.36-2.0) for those who had quit smoking for 10-19 and > or =20 years, respectively. CONCLUSIONS: Our cohort study confirmed that cigarette smoking was associated with an increased risk of death from pancreatic cancer. SN - 0957-5243 UR - https://www.unboundmedicine.com/medline/citation/12020106/A_prospective_cohort_study_of_cigarette_smoking_and_pancreatic_cancer_in_Japan_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=12020106.ui DB - PRIME DP - Unbound Medicine ER -