Tags

Type your tag names separated by a space and hit enter

VRl- and VRL-l-like immunoreactivity in normal and injured trigeminal dental primary sensory neurons of the rat.
Acta Odontol Scand. 2002 Mar; 60(2):72-9.AO

Abstract

The vanilloid receptor VR1 and the vanilloid receptor-like protein VRL-1 are associated with polymodal nociceptors, and may be important for pain processing in normal and injured teeth. Using immunohistochemistry, we have studied the distribution of these receptors in rat pulpal or gingival trigeminal ganglion neurons that were identified through retrograde labeling with fluoro-gold. Twenty-one percent to 34% of tooth pulp-innervating neurons were VRl-positive, while 32%-51% were VRL-1-immunoreactive. However, double-labeling experiments revealed that VR1 and VRL-1 rarely co-existed in the same cells, but rather seemed to be confined to separate subpopulations. Among the gingival neurons, about 25% were VR1-positive and about 41% were VRL-1-immunoreactive. A lesion of the inferior alveolar nerve, which supplies mandibular teeth and gingiva, resulted in a marked down-regulation of VR1 in the affected trigeminal ganglion cells. A down-regulation of VRL-l was also indicated. The results suggest that both VR1 and VRL-1 could have significant roles in pulpal and gingival nociceptive transduction.

Authors+Show Affiliations

Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden. Emma.Stenholm@ofa.ki.seNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12020118

Citation

Stenholm, Emma, et al. "VRl- and VRL-l-like Immunoreactivity in Normal and Injured Trigeminal Dental Primary Sensory Neurons of the Rat." Acta Odontologica Scandinavica, vol. 60, no. 2, 2002, pp. 72-9.
Stenholm E, Bongenhielm U, Ahlquist M, et al. VRl- and VRL-l-like immunoreactivity in normal and injured trigeminal dental primary sensory neurons of the rat. Acta Odontol Scand. 2002;60(2):72-9.
Stenholm, E., Bongenhielm, U., Ahlquist, M., & Fried, K. (2002). VRl- and VRL-l-like immunoreactivity in normal and injured trigeminal dental primary sensory neurons of the rat. Acta Odontologica Scandinavica, 60(2), 72-9.
Stenholm E, et al. VRl- and VRL-l-like Immunoreactivity in Normal and Injured Trigeminal Dental Primary Sensory Neurons of the Rat. Acta Odontol Scand. 2002;60(2):72-9. PubMed PMID: 12020118.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - VRl- and VRL-l-like immunoreactivity in normal and injured trigeminal dental primary sensory neurons of the rat. AU - Stenholm,Emma, AU - Bongenhielm,Ulf, AU - Ahlquist,Michael, AU - Fried,Kaj, PY - 2002/5/22/pubmed PY - 2002/8/10/medline PY - 2002/5/22/entrez SP - 72 EP - 9 JF - Acta odontologica Scandinavica JO - Acta Odontol. Scand. VL - 60 IS - 2 N2 - The vanilloid receptor VR1 and the vanilloid receptor-like protein VRL-1 are associated with polymodal nociceptors, and may be important for pain processing in normal and injured teeth. Using immunohistochemistry, we have studied the distribution of these receptors in rat pulpal or gingival trigeminal ganglion neurons that were identified through retrograde labeling with fluoro-gold. Twenty-one percent to 34% of tooth pulp-innervating neurons were VRl-positive, while 32%-51% were VRL-1-immunoreactive. However, double-labeling experiments revealed that VR1 and VRL-1 rarely co-existed in the same cells, but rather seemed to be confined to separate subpopulations. Among the gingival neurons, about 25% were VR1-positive and about 41% were VRL-1-immunoreactive. A lesion of the inferior alveolar nerve, which supplies mandibular teeth and gingiva, resulted in a marked down-regulation of VR1 in the affected trigeminal ganglion cells. A down-regulation of VRL-l was also indicated. The results suggest that both VR1 and VRL-1 could have significant roles in pulpal and gingival nociceptive transduction. SN - 0001-6357 UR - https://www.unboundmedicine.com/medline/citation/12020118/VRl__and_VRL_l_like_immunoreactivity_in_normal_and_injured_trigeminal_dental_primary_sensory_neurons_of_the_rat_ L2 - http://www.tandfonline.com/doi/full/10.1080/000163502753509455 DB - PRIME DP - Unbound Medicine ER -