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Cardiovascular risk factors and venous thromboembolism incidence: the longitudinal investigation of thromboembolism etiology.

Abstract

BACKGROUND

The association between traditional cardiovascular risk factors and risk of venous thromboembolism (VTE) has not been extensively examined in prospective studies.

METHODS

To determine whether atherosclerotic risk factors are also associated with increased incidence of VTE, we conducted a prospective study of 19 293 men and women without previous VTE in 6 US communities between 1987 and 1998.

RESULTS

There were 215 validated VTE events (1.45 per 1000 person-years) during a median of 8 years of follow-up. The age-adjusted hazard ratio was 1.4 (95% confidence interval [CI], 1.1-1.9) for men vs women, 1.6 (95% CI, 1.2-2.2) for blacks vs whites, and 1.7 (95% CI, 1.5-2.0) per decade of age. Cigarette smoking, hypertension, dyslipidemia, physical inactivity, and alcohol consumption were not associated with risk of VTE. Age-, race-, and sex-adjusted hazard ratios for body mass index categories (calculated as the weight in kilograms divided by the height in meters squared) of less than 25, 25 to less than 30, 30 to less than 35, 35 to less than 40, and 40 or more were 1.0, 1.5, 2.2, 1.5, and 2.7, respectively (P<.001 for the trend). Diabetes was also associated with an increased risk of VTE (adjusted hazard ratio, 1.5 [95% CI, 1.0-2.1]).

CONCLUSIONS

Our data showing no relationship of some arterial risk factors with VTE corroborate the view that the etiology of VTE differs from atherosclerotic cardiovascular disease. In addition, the findings suggest a hypothesis that avoidance of obesity and diabetes or vigilance in prophylaxis in patients with those conditions may prevent some venous thromboses.

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  • Authors+Show Affiliations

    ,

    Division of Epidemiology, School of Public Health, University of Minnesota, 1300 S Second St, Suite 300, Minneapolis, MN 55454, USA.

    , , , ,

    Source

    Archives of internal medicine 162:10 2002 May 27 pg 1182-9

    MeSH

    Aged
    Arteriosclerosis
    Female
    Humans
    Incidence
    Male
    Middle Aged
    Multivariate Analysis
    Proportional Hazards Models
    Prospective Studies
    Pulmonary Embolism
    Risk Factors
    United States
    Venous Thrombosis

    Pub Type(s)

    Journal Article
    Multicenter Study
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    12020191

    Citation

    Tsai, Albert W., et al. "Cardiovascular Risk Factors and Venous Thromboembolism Incidence: the Longitudinal Investigation of Thromboembolism Etiology." Archives of Internal Medicine, vol. 162, no. 10, 2002, pp. 1182-9.
    Tsai AW, Cushman M, Rosamond WD, et al. Cardiovascular risk factors and venous thromboembolism incidence: the longitudinal investigation of thromboembolism etiology. Arch Intern Med. 2002;162(10):1182-9.
    Tsai, A. W., Cushman, M., Rosamond, W. D., Heckbert, S. R., Polak, J. F., & Folsom, A. R. (2002). Cardiovascular risk factors and venous thromboembolism incidence: the longitudinal investigation of thromboembolism etiology. Archives of Internal Medicine, 162(10), pp. 1182-9.
    Tsai AW, et al. Cardiovascular Risk Factors and Venous Thromboembolism Incidence: the Longitudinal Investigation of Thromboembolism Etiology. Arch Intern Med. 2002 May 27;162(10):1182-9. PubMed PMID: 12020191.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Cardiovascular risk factors and venous thromboembolism incidence: the longitudinal investigation of thromboembolism etiology. AU - Tsai,Albert W, AU - Cushman,Mary, AU - Rosamond,Wayne D, AU - Heckbert,Susan R, AU - Polak,Joseph F, AU - Folsom,Aaron R, PY - 2002/5/22/pubmed PY - 2002/6/6/medline PY - 2002/5/22/entrez SP - 1182 EP - 9 JF - Archives of internal medicine JO - Arch. Intern. Med. VL - 162 IS - 10 N2 - BACKGROUND: The association between traditional cardiovascular risk factors and risk of venous thromboembolism (VTE) has not been extensively examined in prospective studies. METHODS: To determine whether atherosclerotic risk factors are also associated with increased incidence of VTE, we conducted a prospective study of 19 293 men and women without previous VTE in 6 US communities between 1987 and 1998. RESULTS: There were 215 validated VTE events (1.45 per 1000 person-years) during a median of 8 years of follow-up. The age-adjusted hazard ratio was 1.4 (95% confidence interval [CI], 1.1-1.9) for men vs women, 1.6 (95% CI, 1.2-2.2) for blacks vs whites, and 1.7 (95% CI, 1.5-2.0) per decade of age. Cigarette smoking, hypertension, dyslipidemia, physical inactivity, and alcohol consumption were not associated with risk of VTE. Age-, race-, and sex-adjusted hazard ratios for body mass index categories (calculated as the weight in kilograms divided by the height in meters squared) of less than 25, 25 to less than 30, 30 to less than 35, 35 to less than 40, and 40 or more were 1.0, 1.5, 2.2, 1.5, and 2.7, respectively (P<.001 for the trend). Diabetes was also associated with an increased risk of VTE (adjusted hazard ratio, 1.5 [95% CI, 1.0-2.1]). CONCLUSIONS: Our data showing no relationship of some arterial risk factors with VTE corroborate the view that the etiology of VTE differs from atherosclerotic cardiovascular disease. In addition, the findings suggest a hypothesis that avoidance of obesity and diabetes or vigilance in prophylaxis in patients with those conditions may prevent some venous thromboses. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/12020191/Cardiovascular_risk_factors_and_venous_thromboembolism_incidence:_the_longitudinal_investigation_of_thromboembolism_etiology_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/vol/162/pg/1182 DB - PRIME DP - Unbound Medicine ER -