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Productive infection of the bone marrow cells in feline immunodeficiency virus infected cats.
Arch Virol. 2002 May; 147(5):1053-9.AV

Abstract

Bone marrow stromal cells (BMSC) from cats experimentally infected with feline immunodeficiency virus (FIV) were shown to contain FIV provirus using polymerase chain reaction and viral products were detected in culture supernatant using reverse transcriptase and enzyme linked immunosorbent assay techniques. Peripheral blood mononuclear cells from FIV-free cats co-cultured with infected bone marrow cells became productively infected with FIV. Such evidence supports the hypothesis that BMSC are a reservoir for FIV. Furthermore, BMSC produced virions capable of infecting susceptible cells and may represent an important source of infectious virus to cells of the macrophage lineage and/or hemopoietic progenitor cells, both of which ultimately become widely disseminated throughout the body.

Authors+Show Affiliations

Sandy JR
School of Pathology, Faculty of Medicine, University of NSW, Australia. j.sandy@unimelb.edu.au
Robinson WF
No affiliation info available
Bredhauer B
No affiliation info available
Kyaw-Tanner M
No affiliation info available
Howlett CR
No affiliation info available

MeSH

AnimalsBone Marrow CellsCatsCells, CulturedCoculture TechniquesImmunodeficiency Virus, FelineLentivirus InfectionsLeukocytes, Mononuclear

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12021873

Citation

Sandy, J R., et al. "Productive Infection of the Bone Marrow Cells in Feline Immunodeficiency Virus Infected Cats." Archives of Virology, vol. 147, no. 5, 2002, pp. 1053-9.
Sandy JR, Robinson WF, Bredhauer B, et al. Productive infection of the bone marrow cells in feline immunodeficiency virus infected cats. Arch Virol. 2002;147(5):1053-9.
Sandy, J. R., Robinson, W. F., Bredhauer, B., Kyaw-Tanner, M., & Howlett, C. R. (2002). Productive infection of the bone marrow cells in feline immunodeficiency virus infected cats. Archives of Virology, 147(5), 1053-9.
Sandy JR, et al. Productive Infection of the Bone Marrow Cells in Feline Immunodeficiency Virus Infected Cats. Arch Virol. 2002;147(5):1053-9. PubMed PMID: 12021873.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Productive infection of the bone marrow cells in feline immunodeficiency virus infected cats. AU - Sandy,J R, AU - Robinson,W F, AU - Bredhauer,B, AU - Kyaw-Tanner,M, AU - Howlett,C R, PY - 2002/5/22/pubmed PY - 2002/7/12/medline PY - 2002/5/22/entrez SP - 1053 EP - 9 JF - Archives of virology JO - Arch Virol VL - 147 IS - 5 N2 - Bone marrow stromal cells (BMSC) from cats experimentally infected with feline immunodeficiency virus (FIV) were shown to contain FIV provirus using polymerase chain reaction and viral products were detected in culture supernatant using reverse transcriptase and enzyme linked immunosorbent assay techniques. Peripheral blood mononuclear cells from FIV-free cats co-cultured with infected bone marrow cells became productively infected with FIV. Such evidence supports the hypothesis that BMSC are a reservoir for FIV. Furthermore, BMSC produced virions capable of infecting susceptible cells and may represent an important source of infectious virus to cells of the macrophage lineage and/or hemopoietic progenitor cells, both of which ultimately become widely disseminated throughout the body. SN - 0304-8608 UR - https://www.unboundmedicine.com/medline/citation/12021873/Productive_infection_of_the_bone_marrow_cells_in_feline_immunodeficiency_virus_infected_cats_ L2 - https://dx.doi.org/10.1007/s00705-001-0790-2 DB - PRIME DP - Unbound Medicine ER -