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Evaluation of Fagara zanthoxyloides root extract in sickle cell anemia blood in vitro.
Lloydia. 1975 Sep-Oct; 38(5):387-90.L

Abstract

An aqueous extract was prepared from roots of Fagara zanthoxyloides and examined for evidence of an antisickling effect in vitro. Addition of 25 mg/ml of the extract to fresh blood samples from sickle anemia subjects produced no change in the blood oxygen dissociation curves, and approximately equal percentages of sickled cells were observed at comparable oxygen saturation levels in the presence or absence of the extract. These observations fail to confirm previous reports describing an antisickling effect of root extracts of Fagara zanthoxyloides.

Authors

Honig GR
No affiliation info available
Farnsworth NR
No affiliation info available
Ferenc C
No affiliation info available
Vida LN
No affiliation info available

MeSH

Anemia, Sickle CellErythrocytes, AbnormalGhanaHumansOxygenPlant ExtractsPlants, Medicinal

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1202311

Citation

Honig, G R., et al. "Evaluation of Fagara Zanthoxyloides Root Extract in Sickle Cell Anemia Blood in Vitro." Lloydia, vol. 38, no. 5, 1975, pp. 387-90.
Honig GR, Farnsworth NR, Ferenc C, et al. Evaluation of Fagara zanthoxyloides root extract in sickle cell anemia blood in vitro. Lloydia. 1975;38(5):387-90.
Honig, G. R., Farnsworth, N. R., Ferenc, C., & Vida, L. N. (1975). Evaluation of Fagara zanthoxyloides root extract in sickle cell anemia blood in vitro. Lloydia, 38(5), 387-90.
Honig GR, et al. Evaluation of Fagara Zanthoxyloides Root Extract in Sickle Cell Anemia Blood in Vitro. Lloydia. 1975 Sep-Oct;38(5):387-90. PubMed PMID: 1202311.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of Fagara zanthoxyloides root extract in sickle cell anemia blood in vitro. AU - Honig,G R, AU - Farnsworth,N R, AU - Ferenc,C, AU - Vida,L N, PY - 1975/9/1/pubmed PY - 1975/9/1/medline PY - 1975/9/1/entrez SP - 387 EP - 90 JF - Lloydia JO - Lloydia VL - 38 IS - 5 N2 - An aqueous extract was prepared from roots of Fagara zanthoxyloides and examined for evidence of an antisickling effect in vitro. Addition of 25 mg/ml of the extract to fresh blood samples from sickle anemia subjects produced no change in the blood oxygen dissociation curves, and approximately equal percentages of sickled cells were observed at comparable oxygen saturation levels in the presence or absence of the extract. These observations fail to confirm previous reports describing an antisickling effect of root extracts of Fagara zanthoxyloides. SN - 0024-5461 UR - https://www.unboundmedicine.com/medline/citation/1202311/Evaluation_of_Fagara_zanthoxyloides_root_extract_in_sickle_cell_anemia_blood_in_vitro_ DB - PRIME DP - Unbound Medicine ER -