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[Tissue antioxidant capacity and bacterial translocation in parenteral nutrition. Experimental study].
Cir Pediatr. 2002 Jan; 15(1):29-33.CP

Abstract

Alterations in the antioxidant system (AS) has been observed during total parenteral nutrition (TPN). Light exposure or changes in the composition of TPN may affect this deleterious effect. On the other hand, bacterial translocation (BT) is frequent under TPN and may be related to AS. The aim of the study was to determine the adverse effect of standard and glutamine-enriched (GE) TPN, with or without light exposure, on the AS, and its relationship to BT. Forty-nine adult Wistar rats underwent central venous cannulation and were randomly assigned to one of five groups: Sham (n = 16): chow and water ad libitum and saline i.v. TPN (n = 10): had standard TPN. TPN(-) (n = 8): standard TPN without light-exposure. GTPN (n = 8): GE TPN. GTPN(-) (n = 7): GE TPN without light exposure. After 10 days, glutation reduced (GSH) was determined in liver and kidney. Mesenteric lymph nodes, peripheral and portal blood samples were cultured for BT. Comparing to Sham rats, TPN groups had statistically significant lower GSH levels, but there were no differences between standard or GE groups nor with or without light exposure groups. Sham animals had 12% BT. Significantly higher BT (p < 0.05) was found in TPN rats: 70% in TPN group, 88% in TPN(-) group, 86% in GTPN(-) animals and only 50% in GTPN group (p = 0.06 vs TPN group). To conclude: 1. TPN reduces antioxidant capacity and induces BT. 2. Glutamine supplementation or light protection do not improve tissue antioxidant capacity under TPN. 3. Glutamine supplementation tends to reduce BT only in the presence of light. 4. Absence of light exposure does not improve BT TPN-related.

Authors+Show Affiliations

Servicio de Cirugía Pediátrica, Complejo Hospitalario Donostia, San Sebastián.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

spa

PubMed ID

12025473

Citation

Eizaguirre, I, et al. "[Tissue Antioxidant Capacity and Bacterial Translocation in Parenteral Nutrition. Experimental Study]." Cirugia Pediatrica : Organo Oficial De La Sociedad Espanola De Cirugia Pediatrica, vol. 15, no. 1, 2002, pp. 29-33.
Eizaguirre I, Aldámiz L, Aldazábal P, et al. [Tissue antioxidant capacity and bacterial translocation in parenteral nutrition. Experimental study]. Cir Pediatr. 2002;15(1):29-33.
Eizaguirre, I., Aldámiz, L., Aldazábal, P., García, N., Asensio, A. B., Bachiller, P., García Arenzana, J. M., Sanjurjo, P., & Pérez Nanclares, G. (2002). [Tissue antioxidant capacity and bacterial translocation in parenteral nutrition. Experimental study]. Cirugia Pediatrica : Organo Oficial De La Sociedad Espanola De Cirugia Pediatrica, 15(1), 29-33.
Eizaguirre I, et al. [Tissue Antioxidant Capacity and Bacterial Translocation in Parenteral Nutrition. Experimental Study]. Cir Pediatr. 2002;15(1):29-33. PubMed PMID: 12025473.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Tissue antioxidant capacity and bacterial translocation in parenteral nutrition. Experimental study]. AU - Eizaguirre,I, AU - Aldámiz,L, AU - Aldazábal,P, AU - García,N, AU - Asensio,A B, AU - Bachiller,P, AU - García Arenzana,J M, AU - Sanjurjo,P, AU - Pérez Nanclares,G, PY - 2002/5/25/pubmed PY - 2003/2/7/medline PY - 2002/5/25/entrez SP - 29 EP - 33 JF - Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica JO - Cir Pediatr VL - 15 IS - 1 N2 - Alterations in the antioxidant system (AS) has been observed during total parenteral nutrition (TPN). Light exposure or changes in the composition of TPN may affect this deleterious effect. On the other hand, bacterial translocation (BT) is frequent under TPN and may be related to AS. The aim of the study was to determine the adverse effect of standard and glutamine-enriched (GE) TPN, with or without light exposure, on the AS, and its relationship to BT. Forty-nine adult Wistar rats underwent central venous cannulation and were randomly assigned to one of five groups: Sham (n = 16): chow and water ad libitum and saline i.v. TPN (n = 10): had standard TPN. TPN(-) (n = 8): standard TPN without light-exposure. GTPN (n = 8): GE TPN. GTPN(-) (n = 7): GE TPN without light exposure. After 10 days, glutation reduced (GSH) was determined in liver and kidney. Mesenteric lymph nodes, peripheral and portal blood samples were cultured for BT. Comparing to Sham rats, TPN groups had statistically significant lower GSH levels, but there were no differences between standard or GE groups nor with or without light exposure groups. Sham animals had 12% BT. Significantly higher BT (p < 0.05) was found in TPN rats: 70% in TPN group, 88% in TPN(-) group, 86% in GTPN(-) animals and only 50% in GTPN group (p = 0.06 vs TPN group). To conclude: 1. TPN reduces antioxidant capacity and induces BT. 2. Glutamine supplementation or light protection do not improve tissue antioxidant capacity under TPN. 3. Glutamine supplementation tends to reduce BT only in the presence of light. 4. Absence of light exposure does not improve BT TPN-related. SN - 0214-1221 UR - https://www.unboundmedicine.com/medline/citation/12025473/[Tissue_antioxidant_capacity_and_bacterial_translocation_in_parenteral_nutrition__Experimental_study]_ DB - PRIME DP - Unbound Medicine ER -