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Ozone differentially modulates airway responsiveness in atopic versus nonatopic guinea pigs.
Inhal Toxicol. 2002 May; 14(5):431-57.IT

Abstract

While acute exposures to ozone (O(3)) can alter airway responsiveness, effects from long-term exposures at low concentrations are less clear. This study assessed whether such exposures could induce nonspecific hyperresponsiveness in nonatopic (nonsensitized) guinea pigs and/or could exacerbate the pre-existing hyperresponsive state in atopic (sensitized) animals, and whether gender was a factor modulating any effect of O(3). Responsiveness was measured during and following exposures to 0.1 and 0.3 ppm O(3) for 4 h/day, 4 days/wk for 24 wk in male and female nonsensitized animals, those sensitized to allergen (ovalbumin) prior to initiation of O(3) exposures, and those sensitized concurrently with exposures. Ozone did not produce hyperresponsiveness in nonsensitized animals, but did exacerbate hyperresponsiveness to both specific and nonspecific bronchoprovocation challenges in sensitized animals, an effect that persisted through at least 4 wk after exposures ended. Gender was not a factor modulating response to O(3). Induced effects on responsiveness were not associated with numbers of eosinophils in the lungs nor with any chronic pulmonary inflammatory response, but were correlated with antigen-specific antibodies in blood. This study supports a role for chronic O(3) exposure in the exacerbation of airways dysfunction in a certain segment of the general population, namely, those demonstrating atopy.

Authors+Show Affiliations

Department of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12028802

Citation

Schlesinger, Richard B., et al. "Ozone Differentially Modulates Airway Responsiveness in Atopic Versus Nonatopic Guinea Pigs." Inhalation Toxicology, vol. 14, no. 5, 2002, pp. 431-57.
Schlesinger RB, Cohen MD, Gordon T, et al. Ozone differentially modulates airway responsiveness in atopic versus nonatopic guinea pigs. Inhal Toxicol. 2002;14(5):431-57.
Schlesinger, R. B., Cohen, M. D., Gordon, T., Nadziejko, C., Zelikoff, J. T., Sisco, M., Regal, J. F., & Ménache, M. G. (2002). Ozone differentially modulates airway responsiveness in atopic versus nonatopic guinea pigs. Inhalation Toxicology, 14(5), 431-57.
Schlesinger RB, et al. Ozone Differentially Modulates Airway Responsiveness in Atopic Versus Nonatopic Guinea Pigs. Inhal Toxicol. 2002;14(5):431-57. PubMed PMID: 12028802.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ozone differentially modulates airway responsiveness in atopic versus nonatopic guinea pigs. AU - Schlesinger,Richard B, AU - Cohen,Mitchell D, AU - Gordon,Terry, AU - Nadziejko,Christine, AU - Zelikoff,Judith T, AU - Sisco,Maureen, AU - Regal,Jean F, AU - Ménache,Margaret G, PY - 2002/5/25/pubmed PY - 2002/6/20/medline PY - 2002/5/25/entrez SP - 431 EP - 57 JF - Inhalation toxicology JO - Inhal Toxicol VL - 14 IS - 5 N2 - While acute exposures to ozone (O(3)) can alter airway responsiveness, effects from long-term exposures at low concentrations are less clear. This study assessed whether such exposures could induce nonspecific hyperresponsiveness in nonatopic (nonsensitized) guinea pigs and/or could exacerbate the pre-existing hyperresponsive state in atopic (sensitized) animals, and whether gender was a factor modulating any effect of O(3). Responsiveness was measured during and following exposures to 0.1 and 0.3 ppm O(3) for 4 h/day, 4 days/wk for 24 wk in male and female nonsensitized animals, those sensitized to allergen (ovalbumin) prior to initiation of O(3) exposures, and those sensitized concurrently with exposures. Ozone did not produce hyperresponsiveness in nonsensitized animals, but did exacerbate hyperresponsiveness to both specific and nonspecific bronchoprovocation challenges in sensitized animals, an effect that persisted through at least 4 wk after exposures ended. Gender was not a factor modulating response to O(3). Induced effects on responsiveness were not associated with numbers of eosinophils in the lungs nor with any chronic pulmonary inflammatory response, but were correlated with antigen-specific antibodies in blood. This study supports a role for chronic O(3) exposure in the exacerbation of airways dysfunction in a certain segment of the general population, namely, those demonstrating atopy. SN - 0895-8378 UR - https://www.unboundmedicine.com/medline/citation/12028802/Ozone_differentially_modulates_airway_responsiveness_in_atopic_versus_nonatopic_guinea_pigs_ L2 - http://www.tandfonline.com/doi/full/10.1080/089583701753678562 DB - PRIME DP - Unbound Medicine ER -