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Stem cells in the treatment of Parkinson's disease.

Abstract

Stem cells have been suggested as candidate therapeutic tools for neurodegenerative disorders, given their ability to give rise to the appropriate cell types after grafting in vivo. In this review I summarize some of the evidence currently available concerning two approaches for the treatment of Parkinson's disease: (1) The generation of dopaminergic neurons from embryonic stem cells, multipotent stem cells, and neuronal progenitor cells for cell replacement therapy. (2) The engineering of multipotent stem cells to release glial cell-line derived neurotrophic factor, a potent neurotrophic factor for dopaminergic neurons, in a neuroprotective and neuroregenerative approach to the treatment of Parkinson's disease.

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  • Publisher Full Text
  • Authors+Show Affiliations

    Laboratory of Molecular Neurobiology, Karolinska Institute, Stockholm, Sweden. ernest.arenas@mbb.ki.se

    Source

    Brain research bulletin 57:6 2002 Apr pg 795-808

    MeSH

    Animals
    Brain Tissue Transplantation
    Cell Culture Techniques
    Cell Differentiation
    Dopamine
    Embryonic Induction
    Humans
    Nerve Growth Factors
    Neurons
    Parkinson Disease
    Stem Cell Transplantation
    Stem Cells
    Substantia Nigra

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    12031276

    Citation

    Arenas, E. "Stem Cells in the Treatment of Parkinson's Disease." Brain Research Bulletin, vol. 57, no. 6, 2002, pp. 795-808.
    Arenas E. Stem cells in the treatment of Parkinson's disease. Brain Res Bull. 2002;57(6):795-808.
    Arenas, E. (2002). Stem cells in the treatment of Parkinson's disease. Brain Research Bulletin, 57(6), pp. 795-808.
    Arenas E. Stem Cells in the Treatment of Parkinson's Disease. Brain Res Bull. 2002;57(6):795-808. PubMed PMID: 12031276.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Stem cells in the treatment of Parkinson's disease. A1 - Arenas,E, PY - 2002/5/29/pubmed PY - 2002/7/18/medline PY - 2002/5/29/entrez SP - 795 EP - 808 JF - Brain research bulletin JO - Brain Res. Bull. VL - 57 IS - 6 N2 - Stem cells have been suggested as candidate therapeutic tools for neurodegenerative disorders, given their ability to give rise to the appropriate cell types after grafting in vivo. In this review I summarize some of the evidence currently available concerning two approaches for the treatment of Parkinson's disease: (1) The generation of dopaminergic neurons from embryonic stem cells, multipotent stem cells, and neuronal progenitor cells for cell replacement therapy. (2) The engineering of multipotent stem cells to release glial cell-line derived neurotrophic factor, a potent neurotrophic factor for dopaminergic neurons, in a neuroprotective and neuroregenerative approach to the treatment of Parkinson's disease. SN - 0361-9230 UR - https://www.unboundmedicine.com/medline/citation/12031276/Stem_cells_in_the_treatment_of_Parkinson's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0361923001007729 DB - PRIME DP - Unbound Medicine ER -