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[Celiac disease and spontaneous abortion].
Minerva Ginecol 2002; 54(2):151-9MG

Abstract

BACKGROUND

Over the last ten years it has become clear that the clinical expression of celiac disease is more heterogeneous than was thought in the past. Although celiac disease is a relatively frequent disease (1/170-200), it is only diagnosed in a small percentage of adult cases compared to the real situation because it is manifested with few symptoms or in an atypical form, or occasionally is completely silent. Gynecological problems have been reported in women with celiac disease, in particular delayed menarche, early menopause, sterility, recurrent abortion and fetal intrauterine growth retardation. The main aim of this study was to investigate the association between celiac disease and abortion, and in particular to evaluate whether patients suffering from recurrent spontaneous abortion might present an atypical or subclinical form of the disease.

METHODS

During the period 1997-1998 a series of laboratory tests were carried out at the Department of Obstetrics and Gynecology and at the Institute of Medicine B of Verona University, in a sample of 184 women (149 from the Obstetrics Clinic and 35 from Internal Medicine B). These tests included circulating anti-gliadin (AGA) and anti-endomysium (EMA) antibodies and total serum immunoglobulins. In positive cases, further diagnostic tests were performed using small bowel biopsy specimens.

RESULTS

In our selected sample of cases, 5 women (2.7%) were positive for immunological screening against IgA-EMA and for bowel biopsy (confirmed diagnosis of celiac disease). Four of these women (2.1%) formed part of a group of patients with a positive history of spontaneous abortion and one (0.5%) was from the control group.

CONCLUSIONS

An analysis of the cases that emerged from this study and those reported in the literature shows that tests to identify the celiac disease should be extended to the population with a risk of developing this disease. These subjects should include those with a family history or clinical symptoms, in particular women with a history of multiple abortions. In these cases, there are grounds for suspecting an atypical form of celiac disease.

Authors+Show Affiliations

Istituto di Clinica Ginecologica e Ostetrica A, Università degli Studi, Verona, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

ita

PubMed ID

12032453

Citation

Foschi, F, et al. "[Celiac Disease and Spontaneous Abortion]." Minerva Ginecologica, vol. 54, no. 2, 2002, pp. 151-9.
Foschi F, Diani F, Zardini E, et al. [Celiac disease and spontaneous abortion]. Minerva Ginecol. 2002;54(2):151-9.
Foschi, F., Diani, F., Zardini, E., Zanoni, G., & Caramaschi, P. (2002). [Celiac disease and spontaneous abortion]. Minerva Ginecologica, 54(2), pp. 151-9.
Foschi F, et al. [Celiac Disease and Spontaneous Abortion]. Minerva Ginecol. 2002;54(2):151-9. PubMed PMID: 12032453.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Celiac disease and spontaneous abortion]. AU - Foschi,F, AU - Diani,F, AU - Zardini,E, AU - Zanoni,G, AU - Caramaschi,P, PY - 2002/5/29/pubmed PY - 2002/10/3/medline PY - 2002/5/29/entrez SP - 151 EP - 9 JF - Minerva ginecologica JO - Minerva Ginecol VL - 54 IS - 2 N2 - BACKGROUND: Over the last ten years it has become clear that the clinical expression of celiac disease is more heterogeneous than was thought in the past. Although celiac disease is a relatively frequent disease (1/170-200), it is only diagnosed in a small percentage of adult cases compared to the real situation because it is manifested with few symptoms or in an atypical form, or occasionally is completely silent. Gynecological problems have been reported in women with celiac disease, in particular delayed menarche, early menopause, sterility, recurrent abortion and fetal intrauterine growth retardation. The main aim of this study was to investigate the association between celiac disease and abortion, and in particular to evaluate whether patients suffering from recurrent spontaneous abortion might present an atypical or subclinical form of the disease. METHODS: During the period 1997-1998 a series of laboratory tests were carried out at the Department of Obstetrics and Gynecology and at the Institute of Medicine B of Verona University, in a sample of 184 women (149 from the Obstetrics Clinic and 35 from Internal Medicine B). These tests included circulating anti-gliadin (AGA) and anti-endomysium (EMA) antibodies and total serum immunoglobulins. In positive cases, further diagnostic tests were performed using small bowel biopsy specimens. RESULTS: In our selected sample of cases, 5 women (2.7%) were positive for immunological screening against IgA-EMA and for bowel biopsy (confirmed diagnosis of celiac disease). Four of these women (2.1%) formed part of a group of patients with a positive history of spontaneous abortion and one (0.5%) was from the control group. CONCLUSIONS: An analysis of the cases that emerged from this study and those reported in the literature shows that tests to identify the celiac disease should be extended to the population with a risk of developing this disease. These subjects should include those with a family history or clinical symptoms, in particular women with a history of multiple abortions. In these cases, there are grounds for suspecting an atypical form of celiac disease. SN - 0026-4784 UR - https://www.unboundmedicine.com/medline/citation/12032453/[Celiac_disease_and_spontaneous_abortion]_ L2 - http://www.diseaseinfosearch.org/result/1186 DB - PRIME DP - Unbound Medicine ER -