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Hydroxyurea therapy associated with declining serum levels of magnesium in children with sickle cell anemia.

Abstract

OBJECTIVE

To obtain quantitative serum levels of total and ionized magnesium (Mg(2+)) in children with homozygous sickle cell anemia (SCA) undergoing therapy with hydroxyurea.

STUDY DESIGN

Five children, ages 11 to 14 years with homozygous SCA, were enrolled in a dose-escalating trial of hydroxyurea over an 18-month period. Serum levels of total and ionized magnesium together with ionized K(+), Na(+), and Ca(2+) were measured before hydroxyurea and every 6 months during hydroxyurea therapy.

RESULTS

Before treatment, 4 of the 5 patients had low or below-normal serum concentrations of Mg(2+) (normal range, 0.51-0.67 mmol/L). All 5 became Mg(2+)-deficient during hydroxyurea therapy, with no indication of recovery until after 12 to 18 months of drug administration (P <.05). Similar changes were noted for total magnesium concentrations. Mean serum levels of K(+), Na(+), and Ca(2+) remained consistently within normal ranges.

CONCLUSIONS

These findings warrant a controlled study of the effects of magnesium supplementation in patients with SCA receiving hydroxyurea. Potentially, such therapy could alleviate or prevent vaso-occlusive crises.

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    Authors+Show Affiliations

    Altura RA
    ,

    Division of Hematology-Oncology, Columbus Children's Hospital and Ohio State University, 43205, USA.

    Wang WC
    ,
    Wynn L
    ,
    Altura BM
    ,
    Altura BT

    Source

    The Journal of pediatrics 140:5 2002 May pg 565-9

    MeSH

    Adolescent
    Analysis of Variance
    Anemia, Sickle Cell
    Antisickling Agents
    Child
    Dose-Response Relationship, Drug
    Female
    Humans
    Hydroxyurea
    Magnesium Deficiency
    Male
    Pilot Projects
    Time Factors

    Pub Type(s)

    Clinical Trial
    Clinical Trial, Phase II
    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    12032523

    Citation

    Altura, Rachel A., et al. "Hydroxyurea Therapy Associated With Declining Serum Levels of Magnesium in Children With Sickle Cell Anemia." The Journal of Pediatrics, vol. 140, no. 5, 2002, pp. 565-9.
    Altura RA, Wang WC, Wynn L, et al. Hydroxyurea therapy associated with declining serum levels of magnesium in children with sickle cell anemia. J Pediatr. 2002;140(5):565-9.
    Altura, R. A., Wang, W. C., Wynn, L., Altura, B. M., & Altura, B. T. (2002). Hydroxyurea therapy associated with declining serum levels of magnesium in children with sickle cell anemia. The Journal of Pediatrics, 140(5), pp. 565-9.
    Altura RA, et al. Hydroxyurea Therapy Associated With Declining Serum Levels of Magnesium in Children With Sickle Cell Anemia. J Pediatr. 2002;140(5):565-9. PubMed PMID: 12032523.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Hydroxyurea therapy associated with declining serum levels of magnesium in children with sickle cell anemia. AU - Altura,Rachel A, AU - Wang,Winfred C, AU - Wynn,Lynn, AU - Altura,Burton M, AU - Altura,Bella T, PY - 2002/5/29/pubmed PY - 2002/7/5/medline PY - 2002/5/29/entrez SP - 565 EP - 9 JF - The Journal of pediatrics JO - J. Pediatr. VL - 140 IS - 5 N2 - OBJECTIVE: To obtain quantitative serum levels of total and ionized magnesium (Mg(2+)) in children with homozygous sickle cell anemia (SCA) undergoing therapy with hydroxyurea. STUDY DESIGN: Five children, ages 11 to 14 years with homozygous SCA, were enrolled in a dose-escalating trial of hydroxyurea over an 18-month period. Serum levels of total and ionized magnesium together with ionized K(+), Na(+), and Ca(2+) were measured before hydroxyurea and every 6 months during hydroxyurea therapy. RESULTS: Before treatment, 4 of the 5 patients had low or below-normal serum concentrations of Mg(2+) (normal range, 0.51-0.67 mmol/L). All 5 became Mg(2+)-deficient during hydroxyurea therapy, with no indication of recovery until after 12 to 18 months of drug administration (P <.05). Similar changes were noted for total magnesium concentrations. Mean serum levels of K(+), Na(+), and Ca(2+) remained consistently within normal ranges. CONCLUSIONS: These findings warrant a controlled study of the effects of magnesium supplementation in patients with SCA receiving hydroxyurea. Potentially, such therapy could alleviate or prevent vaso-occlusive crises. SN - 0022-3476 UR - https://www.unboundmedicine.com/medline/citation/12032523/Hydroxyurea_therapy_associated_with_declining_serum_levels_of_magnesium_in_children_with_sickle_cell_anemia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3476(02)00994-0 DB - PRIME DP - Unbound Medicine ER -