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Dietary flavonoids as potential neuroprotectants.
Biol Chem. 2002 Mar-Apr; 383(3-4):503-19.BC

Abstract

There is an increasing awareness of the role of certain nutritional components, including dietary flavonoids found in fruit, vegetables and beverages, in the maintenance of health and prevention of chronic diseases. In this regard, recent studies highlight an exciting role with respect to their potential neuroprotective actions, in particular towards deficits commonly observed with aging, such as reduced performance of cognitive, memory and learning tasks. These neurological functions, and possible mechanisms involved in controlling them, can be influenced by supplementation of single dietary flavonoids, or as part of a flavonoid-rich preparation. With this, a renewed emphasis is aimed at further understanding their modes and sites of action. Moreover a common theme among many in vitro studies examining mechanisms of neuroprotection is the failure to include biologically relevant metabolites of the flavonoids known to enter the circulation, and thus most likely to be bioavailable to cells and tissues. This oversight will ultimately influence the mechanisms of action proposed to explain the neuroprotection observed in animals and human studies. As such, emerging findings suggest a variety of potential mechanisms of action of flavonoids and their bioavailable metabolites in cytoprotection against oxidative stress, which may be independent of conventional antioxidant reducing activities. Such mechanisms might involve their interaction with cell signalling cascades, their influence on gene expression and the down regulation of pathways leading to cell death.

Authors+Show Affiliations

Wolfson Center for Age-Related Diseases, Guy's King's and St. Thomas's School of Biomedical Sciences, King's College, London, UK.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

12033439

Citation

Youdim, Kuresh A., et al. "Dietary Flavonoids as Potential Neuroprotectants." Biological Chemistry, vol. 383, no. 3-4, 2002, pp. 503-19.
Youdim KA, Spencer JP, Schroeter H, et al. Dietary flavonoids as potential neuroprotectants. Biol Chem. 2002;383(3-4):503-19.
Youdim, K. A., Spencer, J. P., Schroeter, H., & Rice-Evans, C. (2002). Dietary flavonoids as potential neuroprotectants. Biological Chemistry, 383(3-4), 503-19.
Youdim KA, et al. Dietary Flavonoids as Potential Neuroprotectants. Biol Chem. 2002 Mar-Apr;383(3-4):503-19. PubMed PMID: 12033439.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary flavonoids as potential neuroprotectants. AU - Youdim,Kuresh A, AU - Spencer,Jeremy P E, AU - Schroeter,Hagen, AU - Rice-Evans,Catherine, PY - 2002/5/30/pubmed PY - 2002/11/26/medline PY - 2002/5/30/entrez SP - 503 EP - 19 JF - Biological chemistry JO - Biol Chem VL - 383 IS - 3-4 N2 - There is an increasing awareness of the role of certain nutritional components, including dietary flavonoids found in fruit, vegetables and beverages, in the maintenance of health and prevention of chronic diseases. In this regard, recent studies highlight an exciting role with respect to their potential neuroprotective actions, in particular towards deficits commonly observed with aging, such as reduced performance of cognitive, memory and learning tasks. These neurological functions, and possible mechanisms involved in controlling them, can be influenced by supplementation of single dietary flavonoids, or as part of a flavonoid-rich preparation. With this, a renewed emphasis is aimed at further understanding their modes and sites of action. Moreover a common theme among many in vitro studies examining mechanisms of neuroprotection is the failure to include biologically relevant metabolites of the flavonoids known to enter the circulation, and thus most likely to be bioavailable to cells and tissues. This oversight will ultimately influence the mechanisms of action proposed to explain the neuroprotection observed in animals and human studies. As such, emerging findings suggest a variety of potential mechanisms of action of flavonoids and their bioavailable metabolites in cytoprotection against oxidative stress, which may be independent of conventional antioxidant reducing activities. Such mechanisms might involve their interaction with cell signalling cascades, their influence on gene expression and the down regulation of pathways leading to cell death. SN - 1431-6730 UR - https://www.unboundmedicine.com/medline/citation/12033439/Dietary_flavonoids_as_potential_neuroprotectants_ L2 - https://www.degruyter.com/document/doi/10.1515/BC.2002.052 DB - PRIME DP - Unbound Medicine ER -