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Monitoring glaucoma progression with visual evoked potentials of the blue-sensitive pathway.
Invest Ophthalmol Vis Sci. 2002 Jun; 43(6):1828-34.IO

Abstract

PURPOSE

To determine the value of visual evoked potentials with blue-on-yellow pattern stimulation in follow-up of glaucoma.

METHODS

This prospective longitudinal concurrent study included a heterogeneous cohort of two groups, perimetric (n = 161) and preperimetric (n = 118), of patients with chronic open-angle glaucoma and 113 healthy control subjects. In the preperimetric glaucoma group, patients showed glaucomatous abnormalities of the optic disc, maximum intraocular pressure higher than 21 mm Hg, and unremarkable computerized visual field examination results. Patients underwent up to three VEP measurements with blue-on-yellow pattern stimulation, as well as qualitative and morphometric evaluation of color stereo optic disc photographs. Mean follow-up time between measurements was 24 months. VEP measurements were separately analyzed in preperimetric subjects, with and without progression of optic nerve damage. Progression of glaucoma was defined as increasing loss of neuroretinal rim.

RESULTS

A separate analysis of VEP peak times in patients in the preperimetric group, with and without progression of glaucomatous optic nerve damage, showed no significant difference at baseline but a significant prolongation (P = 0.01) in patients with progressive disease, 2 years before morphologic changes were evident. VEPs in patients with nonprogressive disease were statistically unchanged during the observation period. The perimetric group and both preperimetric groups showed significantly prolonged VEP peak times in comparison with the control group (P < 0.001).

CONCLUSIONS

In addition to photographic evaluation to detect glaucomatous disc atrophy, the blue-on-yellow VEP may be an objective electrophysiological tool for monitoring patients with glaucoma, because peak times are significantly associated with progression of optic nerve damage.

Authors+Show Affiliations

Department of Ophthalmology and University Eye Hospital, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany. folkert.horn@augen.imed.uni-erlangen.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12036986

Citation

Horn, Folkert K., et al. "Monitoring Glaucoma Progression With Visual Evoked Potentials of the Blue-sensitive Pathway." Investigative Ophthalmology & Visual Science, vol. 43, no. 6, 2002, pp. 1828-34.
Horn FK, Jonas JB, Budde WM, et al. Monitoring glaucoma progression with visual evoked potentials of the blue-sensitive pathway. Invest Ophthalmol Vis Sci. 2002;43(6):1828-34.
Horn, F. K., Jonas, J. B., Budde, W. M., Jünemann, A. M., Mardin, C. Y., & Korth, M. (2002). Monitoring glaucoma progression with visual evoked potentials of the blue-sensitive pathway. Investigative Ophthalmology & Visual Science, 43(6), 1828-34.
Horn FK, et al. Monitoring Glaucoma Progression With Visual Evoked Potentials of the Blue-sensitive Pathway. Invest Ophthalmol Vis Sci. 2002;43(6):1828-34. PubMed PMID: 12036986.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Monitoring glaucoma progression with visual evoked potentials of the blue-sensitive pathway. AU - Horn,Folkert K, AU - Jonas,Jost B, AU - Budde,Wido M, AU - Jünemann,Anselm M, AU - Mardin,Christian Y, AU - Korth,Matthias, PY - 2002/5/31/pubmed PY - 2002/6/22/medline PY - 2002/5/31/entrez SP - 1828 EP - 34 JF - Investigative ophthalmology & visual science JO - Invest Ophthalmol Vis Sci VL - 43 IS - 6 N2 - PURPOSE: To determine the value of visual evoked potentials with blue-on-yellow pattern stimulation in follow-up of glaucoma. METHODS: This prospective longitudinal concurrent study included a heterogeneous cohort of two groups, perimetric (n = 161) and preperimetric (n = 118), of patients with chronic open-angle glaucoma and 113 healthy control subjects. In the preperimetric glaucoma group, patients showed glaucomatous abnormalities of the optic disc, maximum intraocular pressure higher than 21 mm Hg, and unremarkable computerized visual field examination results. Patients underwent up to three VEP measurements with blue-on-yellow pattern stimulation, as well as qualitative and morphometric evaluation of color stereo optic disc photographs. Mean follow-up time between measurements was 24 months. VEP measurements were separately analyzed in preperimetric subjects, with and without progression of optic nerve damage. Progression of glaucoma was defined as increasing loss of neuroretinal rim. RESULTS: A separate analysis of VEP peak times in patients in the preperimetric group, with and without progression of glaucomatous optic nerve damage, showed no significant difference at baseline but a significant prolongation (P = 0.01) in patients with progressive disease, 2 years before morphologic changes were evident. VEPs in patients with nonprogressive disease were statistically unchanged during the observation period. The perimetric group and both preperimetric groups showed significantly prolonged VEP peak times in comparison with the control group (P < 0.001). CONCLUSIONS: In addition to photographic evaluation to detect glaucomatous disc atrophy, the blue-on-yellow VEP may be an objective electrophysiological tool for monitoring patients with glaucoma, because peak times are significantly associated with progression of optic nerve damage. SN - 0146-0404 UR - https://www.unboundmedicine.com/medline/citation/12036986/Monitoring_glaucoma_progression_with_visual_evoked_potentials_of_the_blue_sensitive_pathway_ L2 - https://iovs.arvojournals.org/article.aspx?volume=43&amp;issue=6&amp;page=1828 DB - PRIME DP - Unbound Medicine ER -