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The C677T thermolabile variant of methylene tetrahydrofolate reductase on homocysteine, folate and vitamin B12 in a hemodialysis center.
Medicina (B Aires) 2002; 62(2):149-53M

Abstract

Homocysteine is a risk factor for cardiovascular disease. Mutations in a key enzyme in homocysteine metabolism, methylenetetrahydrofolate reductase, may contribute to hyperhomocysteinemia and alter folate and cobalamin levels. After starting hemodialysis, 10 mg oral folate daily and 500 micrograms intravenous methylcobalamin once weekly were prescribed to 27 hemodialysis patients (time on hemodialysis > or = 12 months) and two groups were defined: Group A normal; Group B heterozygous. Initial, third and twelfth month measurements of homocysteine, serum folate and vitamin B12 levels were collected and analyzed. Heterozygous state of methylenetetrahydrofolate reductase prevalence was 48% and homozygozity 4%. Hyperhomocysteinemia was present in both groups. Cobalamin final levels were significantly lower in Group B compared to Group A. Homocysteine, serum folate and cobalamin levels at third and twelfth month were significantly different from baseline levels but non-different between them in both groups. In Group B, vitamin B12 at third month was significantly higher than initial, but final measurements were not different from baseline determinations. In conclusion, the heterozygous prevalence of the enzyme in hemodialysis patients is similar to that reported in the general population; hyperhomocysteinemia is frequent in hemodialysis patients and final levels in heterozygous patients are significantly higher than in normal patients. Cobalamin levels are lower in the heterozygous group. After one year of treatment, homocysteine tends to increase, suggesting a secondary resistance phenomenon to vitamin supplementation in heterozygous patients.

Authors+Show Affiliations

Servicio de Nefrología, Nuclear Hospital Británico, Perdriel 74, 1280 Buenos Aires, Argentina. htrimarchi@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng spa

PubMed ID

12038037

Citation

Trimarchi, Hernán, et al. "The C677T Thermolabile Variant of Methylene Tetrahydrofolate Reductase On Homocysteine, Folate and Vitamin B12 in a Hemodialysis Center." Medicina, vol. 62, no. 2, 2002, pp. 149-53.
Trimarchi H, Genoud V, Schiel A, et al. The C677T thermolabile variant of methylene tetrahydrofolate reductase on homocysteine, folate and vitamin B12 in a hemodialysis center. Medicina (B Aires). 2002;62(2):149-53.
Trimarchi, H., Genoud, V., Schiel, A., Castañon, M., Freixas, E., Diaz, M. L., ... Kordich, L. (2002). The C677T thermolabile variant of methylene tetrahydrofolate reductase on homocysteine, folate and vitamin B12 in a hemodialysis center. Medicina, 62(2), pp. 149-53.
Trimarchi H, et al. The C677T Thermolabile Variant of Methylene Tetrahydrofolate Reductase On Homocysteine, Folate and Vitamin B12 in a Hemodialysis Center. Medicina (B Aires). 2002;62(2):149-53. PubMed PMID: 12038037.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The C677T thermolabile variant of methylene tetrahydrofolate reductase on homocysteine, folate and vitamin B12 in a hemodialysis center. AU - Trimarchi,Hernán, AU - Genoud,Valeria, AU - Schiel,Amalia, AU - Castañon,Maria, AU - Freixas,Emilio, AU - Diaz,Maria Luisa, AU - Schropp,Juan, AU - Martino,Diana, AU - Pereyra,Horacio, AU - Kordich,Lucia, PY - 2002/6/1/pubmed PY - 2002/6/14/medline PY - 2002/6/1/entrez SP - 149 EP - 53 JF - Medicina JO - Medicina (B Aires) VL - 62 IS - 2 N2 - Homocysteine is a risk factor for cardiovascular disease. Mutations in a key enzyme in homocysteine metabolism, methylenetetrahydrofolate reductase, may contribute to hyperhomocysteinemia and alter folate and cobalamin levels. After starting hemodialysis, 10 mg oral folate daily and 500 micrograms intravenous methylcobalamin once weekly were prescribed to 27 hemodialysis patients (time on hemodialysis > or = 12 months) and two groups were defined: Group A normal; Group B heterozygous. Initial, third and twelfth month measurements of homocysteine, serum folate and vitamin B12 levels were collected and analyzed. Heterozygous state of methylenetetrahydrofolate reductase prevalence was 48% and homozygozity 4%. Hyperhomocysteinemia was present in both groups. Cobalamin final levels were significantly lower in Group B compared to Group A. Homocysteine, serum folate and cobalamin levels at third and twelfth month were significantly different from baseline levels but non-different between them in both groups. In Group B, vitamin B12 at third month was significantly higher than initial, but final measurements were not different from baseline determinations. In conclusion, the heterozygous prevalence of the enzyme in hemodialysis patients is similar to that reported in the general population; hyperhomocysteinemia is frequent in hemodialysis patients and final levels in heterozygous patients are significantly higher than in normal patients. Cobalamin levels are lower in the heterozygous group. After one year of treatment, homocysteine tends to increase, suggesting a secondary resistance phenomenon to vitamin supplementation in heterozygous patients. SN - 0025-7680 UR - https://www.unboundmedicine.com/medline/citation/12038037/The_C677T_thermolabile_variant_of_methylene_tetrahydrofolate_reductase_on_homocysteine_folate_and_vitamin_B12_in_a_hemodialysis_center_ L2 - https://medlineplus.gov/kidneyfailure.html DB - PRIME DP - Unbound Medicine ER -