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Urinary 2-hydroxyestrone/16alpha-hydroxyestrone ratio and family history of breast cancer in premenopausal women.
Breast Cancer Res Treat 2002; 72(2):139-43BC

Abstract

It has been hypothesized that the ratio of urinary 2-hydroxyestrone to 16alpha-hydroxyestrone (2-OHE1/16alpha-OHE1 represents a biomarker for breast cancer risk; the lower the ratio the higher the risk. We obtained early morning urine samples from 70 'high risk' premenopausal women who had a first degree family history of breast cancer and 27 'low risk' women with no such history. Five estrogen metabolites in urine were determined: 2-OHE1, 16alpha-OHE1, estrone (E1), estradiol (E2), and estriol (E3) conjugates. We compared geometric mean levels of each metabolite adjusted for age and weight. 'High risk' women did not have elevated levels of any of these metabolites. Instead, we observed decrements of 3-27% in women with a family history of breast cancer compared with women without such history, this difference was statistically significant for E2, 2- OHE1, and 16alpha-OHE1. The ratio of 2-OHE1/16alpha-OHE1 was identical in women with and without a family history of breast cancer. These results were unchanged, when additionally adjusted for recent intake of alcohol or cruciferous vegetables. Our data suggest that among premenopausal women, family history is not associated with higher urinary estrogen levels or a lower ratio of urinary 2-OHE1/16alpha-OHE1.

Authors+Show Affiliations

Department of Preventive Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles 90089, USA. gursin@hsc.usc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12038704

Citation

Ursin, Giske, et al. "Urinary 2-hydroxyestrone/16alpha-hydroxyestrone Ratio and Family History of Breast Cancer in Premenopausal Women." Breast Cancer Research and Treatment, vol. 72, no. 2, 2002, pp. 139-43.
Ursin G, London S, Yang D, et al. Urinary 2-hydroxyestrone/16alpha-hydroxyestrone ratio and family history of breast cancer in premenopausal women. Breast Cancer Res Treat. 2002;72(2):139-43.
Ursin, G., London, S., Yang, D., Tseng, C. C., Pike, M. C., Bernstein, L., ... Gentzschein, E. (2002). Urinary 2-hydroxyestrone/16alpha-hydroxyestrone ratio and family history of breast cancer in premenopausal women. Breast Cancer Research and Treatment, 72(2), pp. 139-43.
Ursin G, et al. Urinary 2-hydroxyestrone/16alpha-hydroxyestrone Ratio and Family History of Breast Cancer in Premenopausal Women. Breast Cancer Res Treat. 2002;72(2):139-43. PubMed PMID: 12038704.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Urinary 2-hydroxyestrone/16alpha-hydroxyestrone ratio and family history of breast cancer in premenopausal women. AU - Ursin,Giske, AU - London,Stephanie, AU - Yang,Dongyun, AU - Tseng,Chiu-Chen, AU - Pike,Malcolm C, AU - Bernstein,Leslie, AU - Stanczyk,Frank Z, AU - Gentzschein,Elisabet, PY - 2002/6/1/pubmed PY - 2002/12/10/medline PY - 2002/6/1/entrez SP - 139 EP - 43 JF - Breast cancer research and treatment JO - Breast Cancer Res. Treat. VL - 72 IS - 2 N2 - It has been hypothesized that the ratio of urinary 2-hydroxyestrone to 16alpha-hydroxyestrone (2-OHE1/16alpha-OHE1 represents a biomarker for breast cancer risk; the lower the ratio the higher the risk. We obtained early morning urine samples from 70 'high risk' premenopausal women who had a first degree family history of breast cancer and 27 'low risk' women with no such history. Five estrogen metabolites in urine were determined: 2-OHE1, 16alpha-OHE1, estrone (E1), estradiol (E2), and estriol (E3) conjugates. We compared geometric mean levels of each metabolite adjusted for age and weight. 'High risk' women did not have elevated levels of any of these metabolites. Instead, we observed decrements of 3-27% in women with a family history of breast cancer compared with women without such history, this difference was statistically significant for E2, 2- OHE1, and 16alpha-OHE1. The ratio of 2-OHE1/16alpha-OHE1 was identical in women with and without a family history of breast cancer. These results were unchanged, when additionally adjusted for recent intake of alcohol or cruciferous vegetables. Our data suggest that among premenopausal women, family history is not associated with higher urinary estrogen levels or a lower ratio of urinary 2-OHE1/16alpha-OHE1. SN - 0167-6806 UR - https://www.unboundmedicine.com/medline/citation/12038704/Urinary_2_hydroxyestrone/16alpha_hydroxyestrone_ratio_and_family_history_of_breast_cancer_in_premenopausal_women_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=12038704.ui DB - PRIME DP - Unbound Medicine ER -