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Demonstrating the case that AD is a vascular disease: epidemiologic evidence.

Abstract

Alzheimer's disease (AD) is the most frequent type of dementia in old age. The pathology of AD is not well understood. One hypothesis states that AD has a vascular basis. This hypothesis is controversial because AD has traditionally been studied and treated as a separate disease from vascular dementia. This article reviews the epidemiologic evidence supporting an association between AD and two major vascular risk factors-blood pressure and diabetes. Both methodologic and biologic explanations for these associations are discussed.

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  • Publisher Full Text
  • Authors+Show Affiliations

    Intramural Research Program, Laboratory of Epidemiology, Demography and Biometry, Neuroepidemiology Section, National Institute on Aging, 7201 Wisconsin Avenue, Gateway Building, Suite 3C-309, Bethesda, MD 20892-9205, USA. launerl@nia.nih.gov

    Source

    Ageing research reviews 1:1 2002 Feb pg 61-77

    MeSH

    Aged
    Alzheimer Disease
    Blood Pressure
    Diabetes Complications
    Humans
    Risk Factors
    Vascular Diseases

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, P.H.S.
    Review

    Language

    eng

    PubMed ID

    12039449

    Citation

    Launer, Lenore J.. "Demonstrating the Case That AD Is a Vascular Disease: Epidemiologic Evidence." Ageing Research Reviews, vol. 1, no. 1, 2002, pp. 61-77.
    Launer LJ. Demonstrating the case that AD is a vascular disease: epidemiologic evidence. Ageing Res Rev. 2002;1(1):61-77.
    Launer, L. J. (2002). Demonstrating the case that AD is a vascular disease: epidemiologic evidence. Ageing Research Reviews, 1(1), pp. 61-77.
    Launer LJ. Demonstrating the Case That AD Is a Vascular Disease: Epidemiologic Evidence. Ageing Res Rev. 2002;1(1):61-77. PubMed PMID: 12039449.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Demonstrating the case that AD is a vascular disease: epidemiologic evidence. A1 - Launer,Lenore J, PY - 2002/6/1/pubmed PY - 2002/6/20/medline PY - 2002/6/1/entrez SP - 61 EP - 77 JF - Ageing research reviews JO - Ageing Res. Rev. VL - 1 IS - 1 N2 - Alzheimer's disease (AD) is the most frequent type of dementia in old age. The pathology of AD is not well understood. One hypothesis states that AD has a vascular basis. This hypothesis is controversial because AD has traditionally been studied and treated as a separate disease from vascular dementia. This article reviews the epidemiologic evidence supporting an association between AD and two major vascular risk factors-blood pressure and diabetes. Both methodologic and biologic explanations for these associations are discussed. SN - 1568-1637 UR - https://www.unboundmedicine.com/medline/citation/12039449/Demonstrating_the_case_that_AD_is_a_vascular_disease:_epidemiologic_evidence_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0047637401003645 DB - PRIME DP - Unbound Medicine ER -