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Demonstrating the case that AD is a vascular disease: epidemiologic evidence.
Ageing Res Rev 2002; 1(1):61-77AR

Abstract

Alzheimer's disease (AD) is the most frequent type of dementia in old age. The pathology of AD is not well understood. One hypothesis states that AD has a vascular basis. This hypothesis is controversial because AD has traditionally been studied and treated as a separate disease from vascular dementia. This article reviews the epidemiologic evidence supporting an association between AD and two major vascular risk factors-blood pressure and diabetes. Both methodologic and biologic explanations for these associations are discussed.

Authors+Show Affiliations

Intramural Research Program, Laboratory of Epidemiology, Demography and Biometry, Neuroepidemiology Section, National Institute on Aging, 7201 Wisconsin Avenue, Gateway Building, Suite 3C-309, Bethesda, MD 20892-9205, USA. launerl@nia.nih.gov

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

12039449

Citation

Launer, Lenore J.. "Demonstrating the Case That AD Is a Vascular Disease: Epidemiologic Evidence." Ageing Research Reviews, vol. 1, no. 1, 2002, pp. 61-77.
Launer LJ. Demonstrating the case that AD is a vascular disease: epidemiologic evidence. Ageing Res Rev. 2002;1(1):61-77.
Launer, L. J. (2002). Demonstrating the case that AD is a vascular disease: epidemiologic evidence. Ageing Research Reviews, 1(1), pp. 61-77.
Launer LJ. Demonstrating the Case That AD Is a Vascular Disease: Epidemiologic Evidence. Ageing Res Rev. 2002;1(1):61-77. PubMed PMID: 12039449.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Demonstrating the case that AD is a vascular disease: epidemiologic evidence. A1 - Launer,Lenore J, PY - 2002/6/1/pubmed PY - 2002/6/20/medline PY - 2002/6/1/entrez SP - 61 EP - 77 JF - Ageing research reviews JO - Ageing Res. Rev. VL - 1 IS - 1 N2 - Alzheimer's disease (AD) is the most frequent type of dementia in old age. The pathology of AD is not well understood. One hypothesis states that AD has a vascular basis. This hypothesis is controversial because AD has traditionally been studied and treated as a separate disease from vascular dementia. This article reviews the epidemiologic evidence supporting an association between AD and two major vascular risk factors-blood pressure and diabetes. Both methodologic and biologic explanations for these associations are discussed. SN - 1568-1637 UR - https://www.unboundmedicine.com/medline/citation/12039449/Demonstrating_the_case_that_AD_is_a_vascular_disease:_epidemiologic_evidence_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0047637401003645 DB - PRIME DP - Unbound Medicine ER -