Tags

Type your tag names separated by a space and hit enter

Electrochemical analysis of acetaminophen using a boron-doped diamond thin film electrode applied to flow injection system.
J Pharm Biomed Anal. 2002 Jun 01; 28(5):841-7.JP

Abstract

The electrochemistry of acetaminophen in phosphate buffer solution (pH 8) was studied at a boron-doped diamond (BDD) thin film electrode using cyclic voltammetry, hydrodynamic voltammetry, and flow injection with amperometric detection. Cyclic voltammetry was used to study the reaction as a function of concentration of analyte. Comparison experiments were performed using a polished glassy carbon (GC) electrode. Acetaminophen undergoes quasi-reversible reaction at both of these two electrodes. The BDD and GC electrodes provided well-resolved cyclic voltammograms but the voltammetric signal-to-background ratios obtained from the diamond electrode were higher than those obtained from the GC electrode. The diamond electrode provided a linear dynamic range from 0.1 to 8 mM and a detection of 10 microM (S/B approximately 3) for voltammetric measurement. The flow injection analysis results at the diamond electrode indicated a linear dynamic range from 0.5 to 50 microM and a detection limit of 10 nM (S/N approximately 4). Acetaminophen in syrup samples has also been investigated. The results obtained in the recovery study (24.68+/-0.26 mg/ml) were comparable to those labeled (24 mg/ml).

Authors+Show Affiliations

Department of Chemistry, Faculty of Science, Chulalongkorn University, 254 Phyathai Road Patumwan, 10330, Bangkok, Thailand.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12039625

Citation

Wangfuengkanagul, Nattakarn, and Orawon Chailapakul. "Electrochemical Analysis of Acetaminophen Using a Boron-doped Diamond Thin Film Electrode Applied to Flow Injection System." Journal of Pharmaceutical and Biomedical Analysis, vol. 28, no. 5, 2002, pp. 841-7.
Wangfuengkanagul N, Chailapakul O. Electrochemical analysis of acetaminophen using a boron-doped diamond thin film electrode applied to flow injection system. J Pharm Biomed Anal. 2002;28(5):841-7.
Wangfuengkanagul, N., & Chailapakul, O. (2002). Electrochemical analysis of acetaminophen using a boron-doped diamond thin film electrode applied to flow injection system. Journal of Pharmaceutical and Biomedical Analysis, 28(5), 841-7.
Wangfuengkanagul N, Chailapakul O. Electrochemical Analysis of Acetaminophen Using a Boron-doped Diamond Thin Film Electrode Applied to Flow Injection System. J Pharm Biomed Anal. 2002 Jun 1;28(5):841-7. PubMed PMID: 12039625.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Electrochemical analysis of acetaminophen using a boron-doped diamond thin film electrode applied to flow injection system. AU - Wangfuengkanagul,Nattakarn, AU - Chailapakul,Orawon, PY - 2002/6/1/pubmed PY - 2002/8/7/medline PY - 2002/6/1/entrez SP - 841 EP - 7 JF - Journal of pharmaceutical and biomedical analysis JO - J Pharm Biomed Anal VL - 28 IS - 5 N2 - The electrochemistry of acetaminophen in phosphate buffer solution (pH 8) was studied at a boron-doped diamond (BDD) thin film electrode using cyclic voltammetry, hydrodynamic voltammetry, and flow injection with amperometric detection. Cyclic voltammetry was used to study the reaction as a function of concentration of analyte. Comparison experiments were performed using a polished glassy carbon (GC) electrode. Acetaminophen undergoes quasi-reversible reaction at both of these two electrodes. The BDD and GC electrodes provided well-resolved cyclic voltammograms but the voltammetric signal-to-background ratios obtained from the diamond electrode were higher than those obtained from the GC electrode. The diamond electrode provided a linear dynamic range from 0.1 to 8 mM and a detection of 10 microM (S/B approximately 3) for voltammetric measurement. The flow injection analysis results at the diamond electrode indicated a linear dynamic range from 0.5 to 50 microM and a detection limit of 10 nM (S/N approximately 4). Acetaminophen in syrup samples has also been investigated. The results obtained in the recovery study (24.68+/-0.26 mg/ml) were comparable to those labeled (24 mg/ml). SN - 0731-7085 UR - https://www.unboundmedicine.com/medline/citation/12039625/Electrochemical_analysis_of_acetaminophen_using_a_boron_doped_diamond_thin_film_electrode_applied_to_flow_injection_system_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0731708501006951 DB - PRIME DP - Unbound Medicine ER -