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Connections and regulation of the human estrogen receptor.
Science. 2002 May 31; 296(5573):1642-4.Sci

Abstract

Estrogen regulates a plethora of functionally dissimilar processes in a broad range of tissues. Recent progress in the study of the molecular mechanism of action of estrogen(s) has revealed why different cells can respond to the same hormone in a different manner. Three of these findings are of particular importance: (i) There are two genetically and functionally distinct estrogen receptors that have distinct expression patterns in vivo; (ii) the positive and negative transcriptional activities of these receptors require them to engage transcription cofactors (coactivators or corepressors) in target cells; and (iii) not all cofactors are functionally equivalent, nor are they expressed in the same manner in all cells. Thus, although the estrogen receptor is required for a cell to respond to an estrogenic stimulus, the nature and extent of that response are determined by the proteins, pathways, and processes with which the receptor interacts.

Authors+Show Affiliations

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Box 3813, Durham, NC 27710, USA. donald.mcdonnell@duke.eduNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

12040178

Citation

McDonnell, Donald P., and John D. Norris. "Connections and Regulation of the Human Estrogen Receptor." Science (New York, N.Y.), vol. 296, no. 5573, 2002, pp. 1642-4.
McDonnell DP, Norris JD. Connections and regulation of the human estrogen receptor. Science. 2002;296(5573):1642-4.
McDonnell, D. P., & Norris, J. D. (2002). Connections and regulation of the human estrogen receptor. Science (New York, N.Y.), 296(5573), 1642-4.
McDonnell DP, Norris JD. Connections and Regulation of the Human Estrogen Receptor. Science. 2002 May 31;296(5573):1642-4. PubMed PMID: 12040178.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Connections and regulation of the human estrogen receptor. AU - McDonnell,Donald P, AU - Norris,John D, PY - 2002/6/1/pubmed PY - 2002/7/6/medline PY - 2002/6/1/entrez SP - 1642 EP - 4 JF - Science (New York, N.Y.) JO - Science VL - 296 IS - 5573 N2 - Estrogen regulates a plethora of functionally dissimilar processes in a broad range of tissues. Recent progress in the study of the molecular mechanism of action of estrogen(s) has revealed why different cells can respond to the same hormone in a different manner. Three of these findings are of particular importance: (i) There are two genetically and functionally distinct estrogen receptors that have distinct expression patterns in vivo; (ii) the positive and negative transcriptional activities of these receptors require them to engage transcription cofactors (coactivators or corepressors) in target cells; and (iii) not all cofactors are functionally equivalent, nor are they expressed in the same manner in all cells. Thus, although the estrogen receptor is required for a cell to respond to an estrogenic stimulus, the nature and extent of that response are determined by the proteins, pathways, and processes with which the receptor interacts. SN - 1095-9203 UR - https://www.unboundmedicine.com/medline/citation/12040178/Connections_and_regulation_of_the_human_estrogen_receptor_ L2 - https:///www.science.org/doi/10.1126/science.1071884?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -