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The gray zone in breast fine needle aspiration cytology. How to report on it?
Acta Cytol. 2002 May-Jun; 46(3):513-8.AC

Abstract

OBJECTIVE

To study the "gray zone" in breast fine needle aspiration cytology in which an unequivocal diagnosis cannot be reached with fine needle aspiration cytology findings.

STUDY DESIGN

This study compared cytology and histopathology of 72 breast lesions in which an initial cytologic diagnosis of atypia was given.

RESULTS

There were 36 benign (50%) and 36 malignant (50%) histologic biopsy cases in the cytologic atypia group. Anisonucleosis, chromatin and nuclear membrane irregularity, and presence of myoepithelial cells were significantly different in benign and malignant cases.

CONCLUSION

The gray zone in breast fine needle aspiration cytology is a broad spectrum that changes from proliferative fibrocystic disease to sclerosing adenosis to malignancy. Diagnosing gray zone pathology as atypical in fine needle aspiration cytology causes no delay in treatment as excisional biopsy is recommended for all equivocal cases.

Authors+Show Affiliations

Department of Pathology, Faculty of Medicine, University of Kocaeli, Izmit, Kocaeli, Turkey.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

12040646

Citation

Ozkara, Sevgiye Kaçar, et al. "The Gray Zone in Breast Fine Needle Aspiration Cytology. How to Report On It?" Acta Cytologica, vol. 46, no. 3, 2002, pp. 513-8.
Ozkara SK, Ustün MO, Paksoy N. The gray zone in breast fine needle aspiration cytology. How to report on it? Acta Cytol. 2002;46(3):513-8.
Ozkara, S. K., Ustün, M. O., & Paksoy, N. (2002). The gray zone in breast fine needle aspiration cytology. How to report on it? Acta Cytologica, 46(3), 513-8.
Ozkara SK, Ustün MO, Paksoy N. The Gray Zone in Breast Fine Needle Aspiration Cytology. How to Report On It. Acta Cytol. 2002 May-Jun;46(3):513-8. PubMed PMID: 12040646.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The gray zone in breast fine needle aspiration cytology. How to report on it? AU - Ozkara,Sevgiye Kaçar, AU - Ustün,Melek Ozkal, AU - Paksoy,Nadir, PY - 2002/6/4/pubmed PY - 2002/6/26/medline PY - 2002/6/4/entrez SP - 513 EP - 8 JF - Acta cytologica JO - Acta Cytol VL - 46 IS - 3 N2 - OBJECTIVE: To study the "gray zone" in breast fine needle aspiration cytology in which an unequivocal diagnosis cannot be reached with fine needle aspiration cytology findings. STUDY DESIGN: This study compared cytology and histopathology of 72 breast lesions in which an initial cytologic diagnosis of atypia was given. RESULTS: There were 36 benign (50%) and 36 malignant (50%) histologic biopsy cases in the cytologic atypia group. Anisonucleosis, chromatin and nuclear membrane irregularity, and presence of myoepithelial cells were significantly different in benign and malignant cases. CONCLUSION: The gray zone in breast fine needle aspiration cytology is a broad spectrum that changes from proliferative fibrocystic disease to sclerosing adenosis to malignancy. Diagnosing gray zone pathology as atypical in fine needle aspiration cytology causes no delay in treatment as excisional biopsy is recommended for all equivocal cases. SN - 0001-5547 UR - https://www.unboundmedicine.com/medline/citation/12040646/The_gray_zone_in_breast_fine_needle_aspiration_cytology__How_to_report_on_it L2 - https://www.karger.com?DOI=10.1159/000326870 DB - PRIME DP - Unbound Medicine ER -