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Serum levels of antioxidant vitamins and lipid peroxidation in multiple sclerosis.

Abstract

We determined serum levels of ascorbic acid, betacarotene, retinol and alpha tocopherol and lipid peroxidation (as estimated by thiobarbituric acid reacting substances (TBARS) generation) in 24 multiple sclerosis (MS) patients and 24 healthy sex- and age-matched person as control. The levels of four antioxidant vitamins were significantly lower in MS patients compared to controls (p < 0.05). TBARS levels were significantly higher in the patients of MS compared to the controls (p = 0.001). In MS patients, the levels of beta-carotene, alpha tocopherol and ascorbic acid correlated significantly with each other (r2 = 0.689 - 0.779). It appeared that there was inverse correlation between the serum levels of ascorbic acid or beta-carotene, but not of alpha tocopherol or retinol, and TBARS levels in MS. The present study indicates that antioxidant vitamins (alpha tocopherol, beta-carotene, retinol and ascorbic acid) are decreased in sera of MS patients during an attack, and that this decrease may well be dependent on the increased oxidative burden as reflected by lipid peroxidation products. The role of antioxidant vitamin supplementation in prevention and/or treatment of MS remains to be explored.

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  • Authors+Show Affiliations

    ,

    Department of Nutrition and Dietetics, School of Health Technology, Hacettepe University, Sihhiye, Ankara, Turkey. htbf@hacettepe.edu.tr

    ,

    Source

    Nutritional neuroscience 5:3 2002 Jun pg 215-20

    MeSH

    Adult
    Antioxidants
    Ascorbic Acid
    Female
    Humans
    Lipid Peroxidation
    Male
    Multiple Sclerosis
    Thiobarbituric Acid Reactive Substances
    Vitamin A
    Vitamins
    alpha-Tocopherol
    beta Carotene

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    12041878

    Citation

    Besler, Halit Tanju, et al. "Serum Levels of Antioxidant Vitamins and Lipid Peroxidation in Multiple Sclerosis." Nutritional Neuroscience, vol. 5, no. 3, 2002, pp. 215-20.
    Besler HT, Comoğlu S, Okçu Z. Serum levels of antioxidant vitamins and lipid peroxidation in multiple sclerosis. Nutr Neurosci. 2002;5(3):215-20.
    Besler, H. T., Comoğlu, S., & Okçu, Z. (2002). Serum levels of antioxidant vitamins and lipid peroxidation in multiple sclerosis. Nutritional Neuroscience, 5(3), pp. 215-20.
    Besler HT, Comoğlu S, Okçu Z. Serum Levels of Antioxidant Vitamins and Lipid Peroxidation in Multiple Sclerosis. Nutr Neurosci. 2002;5(3):215-20. PubMed PMID: 12041878.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Serum levels of antioxidant vitamins and lipid peroxidation in multiple sclerosis. AU - Besler,Halit Tanju, AU - Comoğlu,Selçuk, AU - Okçu,Zeki, PY - 2002/6/4/pubmed PY - 2002/11/26/medline PY - 2002/6/4/entrez SP - 215 EP - 20 JF - Nutritional neuroscience JO - Nutr Neurosci VL - 5 IS - 3 N2 - We determined serum levels of ascorbic acid, betacarotene, retinol and alpha tocopherol and lipid peroxidation (as estimated by thiobarbituric acid reacting substances (TBARS) generation) in 24 multiple sclerosis (MS) patients and 24 healthy sex- and age-matched person as control. The levels of four antioxidant vitamins were significantly lower in MS patients compared to controls (p < 0.05). TBARS levels were significantly higher in the patients of MS compared to the controls (p = 0.001). In MS patients, the levels of beta-carotene, alpha tocopherol and ascorbic acid correlated significantly with each other (r2 = 0.689 - 0.779). It appeared that there was inverse correlation between the serum levels of ascorbic acid or beta-carotene, but not of alpha tocopherol or retinol, and TBARS levels in MS. The present study indicates that antioxidant vitamins (alpha tocopherol, beta-carotene, retinol and ascorbic acid) are decreased in sera of MS patients during an attack, and that this decrease may well be dependent on the increased oxidative burden as reflected by lipid peroxidation products. The role of antioxidant vitamin supplementation in prevention and/or treatment of MS remains to be explored. SN - 1028-415X UR - https://www.unboundmedicine.com/medline/citation/12041878/Serum_levels_of_antioxidant_vitamins_and_lipid_peroxidation_in_multiple_sclerosis_ L2 - http://www.tandfonline.com/doi/full/10.1080/10284150290029205 DB - PRIME DP - Unbound Medicine ER -