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An open randomized study of inactivated hepatitis A vaccine administered concomitantly with typhoid fever and yellow fever vaccines.
J Travel Med. 2002 Mar-Apr; 9(2):66-70.JT

Abstract

BACKGROUND

Concomitant administration of several vaccines is a common practice when travel clinics prepare persons for international travel. The purpose of the study was to compare the immunogenicity and safety of hepatitis A, typhoid fever, and yellow fever vaccines administered concomitantly with hepatitis A vaccine administered alone and typhoid fever and yellow fever vaccines administered alone.

METHODS

Healthy adults 18 to 55 years of age were randomized to receive either VAQTA, TyphimVi, and YF-VAX on day 0 and VAQTA at week 24 (Group 1); TyphimVi and YF-VAX on day 0 and an optional dose of VAQTA 1 month later (Group 2); or VAQTA at day 0 and week 24 (Group 3).

RESULTS

From March to December 1997, a total of 240 subjects were enrolled, 80 in each treatment group. Most were female and Caucasian, and the mean age was 29.4 years. Four weeks after vaccine dose 1, seroconversion to protective antibody levels against hepatitis A was 95.9% in Group 1 and 100% in Group 3. In Group 1, 93.4% of subjects demonstrated at least a 4-fold rise in neutralizing antibody levels against typhoid, compared with 90% in Group 2. Serum neutralizing antibody against yellow fever developed in 98.6% of subjects in Group 1 compared with 100% in Group 2.

CONCLUSIONS

These findings were consistent with similarity in the immune responses between treatment groups as defined a priori. The adverse experience (AE) profile did not appear to be substantially affected by concomitant administration of all three vaccines. Providing these three vaccines concomitantly can simplify the process of obtaining pretravel prophylaxis and may help ensure that all needed vaccines are administered.

Authors+Show Affiliations

University of Washington School of Medicine, Seattle, Washington, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12044272

Citation

Jong, Elaine C., et al. "An Open Randomized Study of Inactivated Hepatitis a Vaccine Administered Concomitantly With Typhoid Fever and Yellow Fever Vaccines." Journal of Travel Medicine, vol. 9, no. 2, 2002, pp. 66-70.
Jong EC, Kaplan KM, Eves KA, et al. An open randomized study of inactivated hepatitis A vaccine administered concomitantly with typhoid fever and yellow fever vaccines. J Travel Med. 2002;9(2):66-70.
Jong, E. C., Kaplan, K. M., Eves, K. A., Taddeo, C. A., Lakkis, H. D., & Kuter, B. J. (2002). An open randomized study of inactivated hepatitis A vaccine administered concomitantly with typhoid fever and yellow fever vaccines. Journal of Travel Medicine, 9(2), 66-70.
Jong EC, et al. An Open Randomized Study of Inactivated Hepatitis a Vaccine Administered Concomitantly With Typhoid Fever and Yellow Fever Vaccines. J Travel Med. 2002 Mar-Apr;9(2):66-70. PubMed PMID: 12044272.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An open randomized study of inactivated hepatitis A vaccine administered concomitantly with typhoid fever and yellow fever vaccines. AU - Jong,Elaine C, AU - Kaplan,Karen M, AU - Eves,Karen A, AU - Taddeo,Colleen A, AU - Lakkis,Hassan D, AU - Kuter,Barbara J, PY - 2002/6/5/pubmed PY - 2002/6/21/medline PY - 2002/6/5/entrez SP - 66 EP - 70 JF - Journal of travel medicine JO - J Travel Med VL - 9 IS - 2 N2 - BACKGROUND: Concomitant administration of several vaccines is a common practice when travel clinics prepare persons for international travel. The purpose of the study was to compare the immunogenicity and safety of hepatitis A, typhoid fever, and yellow fever vaccines administered concomitantly with hepatitis A vaccine administered alone and typhoid fever and yellow fever vaccines administered alone. METHODS: Healthy adults 18 to 55 years of age were randomized to receive either VAQTA, TyphimVi, and YF-VAX on day 0 and VAQTA at week 24 (Group 1); TyphimVi and YF-VAX on day 0 and an optional dose of VAQTA 1 month later (Group 2); or VAQTA at day 0 and week 24 (Group 3). RESULTS: From March to December 1997, a total of 240 subjects were enrolled, 80 in each treatment group. Most were female and Caucasian, and the mean age was 29.4 years. Four weeks after vaccine dose 1, seroconversion to protective antibody levels against hepatitis A was 95.9% in Group 1 and 100% in Group 3. In Group 1, 93.4% of subjects demonstrated at least a 4-fold rise in neutralizing antibody levels against typhoid, compared with 90% in Group 2. Serum neutralizing antibody against yellow fever developed in 98.6% of subjects in Group 1 compared with 100% in Group 2. CONCLUSIONS: These findings were consistent with similarity in the immune responses between treatment groups as defined a priori. The adverse experience (AE) profile did not appear to be substantially affected by concomitant administration of all three vaccines. Providing these three vaccines concomitantly can simplify the process of obtaining pretravel prophylaxis and may help ensure that all needed vaccines are administered. SN - 1195-1982 UR - https://www.unboundmedicine.com/medline/citation/12044272/An_open_randomized_study_of_inactivated_hepatitis_A_vaccine_administered_concomitantly_with_typhoid_fever_and_yellow_fever_vaccines_ L2 - https://academic.oup.com/jtm/article-lookup/doi/10.2310/7060.2002.21955 DB - PRIME DP - Unbound Medicine ER -