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Cow's milk allergy in infancy.
Curr Opin Allergy Clin Immunol 2002; 2(3):217-25CO

Abstract

Cow's milk allergy affects approximately 2% of infants under 2 years of age. This review summarizes the recent advances in understanding its pathophysiology and immunological mechanisms. Apart from IgE-mediated atopic manifestations, T cell-mediated reactions have been demonstrated in infants with cow's milk allergy. The clinical spectrum ranges from immediate-type reactions, presenting with urticaria and angioedema to intermediate and late-onset reactions, including atopic dermatitis, infantile colic, gastro-oesophageal reflux, oesophagitis, infantile proctocolitis, food-associated enterocolitis and constipation. The exact mechanisms of these disorders are still poorly understood. Double-blind, placebo controlled food challenge, the definitive diagnostic test for cow's milk allergy, is increasingly being replaced by the measurement of food-specific antibodies, in combination with skin-prick or atopy patch testing. The treatment of cow's milk allergy relies on allergen avoidance and hypoallergenic formulae, or maternal elimination diets in breast-fed infants.

Authors+Show Affiliations

Department of Allergy, Royal Children's Hospital, Parkville, Victoria, Australia. heiner@cryptic.rch.unimelb.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

12045418

Citation

Heine, Ralf G., et al. "Cow's Milk Allergy in Infancy." Current Opinion in Allergy and Clinical Immunology, vol. 2, no. 3, 2002, pp. 217-25.
Heine RG, Elsayed S, Hosking CS, et al. Cow's milk allergy in infancy. Curr Opin Allergy Clin Immunol. 2002;2(3):217-25.
Heine, R. G., Elsayed, S., Hosking, C. S., & Hill, D. J. (2002). Cow's milk allergy in infancy. Current Opinion in Allergy and Clinical Immunology, 2(3), pp. 217-25.
Heine RG, et al. Cow's Milk Allergy in Infancy. Curr Opin Allergy Clin Immunol. 2002;2(3):217-25. PubMed PMID: 12045418.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cow's milk allergy in infancy. AU - Heine,Ralf G, AU - Elsayed,Said, AU - Hosking,Clifford S, AU - Hill,David J, PY - 2002/6/5/pubmed PY - 2002/10/19/medline PY - 2002/6/5/entrez SP - 217 EP - 25 JF - Current opinion in allergy and clinical immunology JO - Curr Opin Allergy Clin Immunol VL - 2 IS - 3 N2 - Cow's milk allergy affects approximately 2% of infants under 2 years of age. This review summarizes the recent advances in understanding its pathophysiology and immunological mechanisms. Apart from IgE-mediated atopic manifestations, T cell-mediated reactions have been demonstrated in infants with cow's milk allergy. The clinical spectrum ranges from immediate-type reactions, presenting with urticaria and angioedema to intermediate and late-onset reactions, including atopic dermatitis, infantile colic, gastro-oesophageal reflux, oesophagitis, infantile proctocolitis, food-associated enterocolitis and constipation. The exact mechanisms of these disorders are still poorly understood. Double-blind, placebo controlled food challenge, the definitive diagnostic test for cow's milk allergy, is increasingly being replaced by the measurement of food-specific antibodies, in combination with skin-prick or atopy patch testing. The treatment of cow's milk allergy relies on allergen avoidance and hypoallergenic formulae, or maternal elimination diets in breast-fed infants. SN - 1528-4050 UR - https://www.unboundmedicine.com/medline/citation/12045418/full_citation L2 - http://Insights.ovid.com/pubmed?pmid=12045418 DB - PRIME DP - Unbound Medicine ER -