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Novel approaches for the treatment of food allergy.

Abstract

At present there is no effective therapy for IgE-mediated food allergy, and patients must rely upon food-allergen avoidance. Unfortunately, the accidental ingestion of allergen-containing foods leading to potentially severe reactions is common. Definitive therapies for food allergy are desperately needed. Although rush immunotherapy has been reported to induce tolerance in some patients, the rate of maintenance of tolerance was low, and there was an undesirably high incidence of adverse reactions. New knowledge of the immunological mechanisms underlying allergic disease has expanded the potential therapeutic options for food allergy. The establishment of animal models of food hypersensitivity, which include sensitization by the oral route and anaphylaxis upon oral challenge, have facilitated the investigation of therapies for food allergy. Novel approaches under investigation include the reduction of IgE by the infusion of anti-IgE antibodies, vaccination with plasmid DNA, the use of anti-allergy immunostimulatory sequences, cytokines and bacterial agents, immunotherapy with mutated proteins and peptides, and complementary medicine such as Chinese herbs.

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  • Authors+Show Affiliations

    ,

    Department of Pediatrics, Mount Sinai School of Medicine, New York, New York 10029-6574, USA. xiu-min.li@mssm.edu

    Source

    MeSH

    Antibody Specificity
    Desensitization, Immunologic
    Food Hypersensitivity
    Humans
    Immunoglobulin E
    Milk Proteins
    United States

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    12045426

    Citation

    Li, Xiu-Min, and Hugh A. Sampson. "Novel Approaches for the Treatment of Food Allergy." Current Opinion in Allergy and Clinical Immunology, vol. 2, no. 3, 2002, pp. 273-8.
    Li XM, Sampson HA. Novel approaches for the treatment of food allergy. Curr Opin Allergy Clin Immunol. 2002;2(3):273-8.
    Li, X. M., & Sampson, H. A. (2002). Novel approaches for the treatment of food allergy. Current Opinion in Allergy and Clinical Immunology, 2(3), pp. 273-8.
    Li XM, Sampson HA. Novel Approaches for the Treatment of Food Allergy. Curr Opin Allergy Clin Immunol. 2002;2(3):273-8. PubMed PMID: 12045426.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Novel approaches for the treatment of food allergy. AU - Li,Xiu-Min, AU - Sampson,Hugh A, PY - 2002/6/5/pubmed PY - 2002/10/19/medline PY - 2002/6/5/entrez SP - 273 EP - 8 JF - Current opinion in allergy and clinical immunology JO - Curr Opin Allergy Clin Immunol VL - 2 IS - 3 N2 - At present there is no effective therapy for IgE-mediated food allergy, and patients must rely upon food-allergen avoidance. Unfortunately, the accidental ingestion of allergen-containing foods leading to potentially severe reactions is common. Definitive therapies for food allergy are desperately needed. Although rush immunotherapy has been reported to induce tolerance in some patients, the rate of maintenance of tolerance was low, and there was an undesirably high incidence of adverse reactions. New knowledge of the immunological mechanisms underlying allergic disease has expanded the potential therapeutic options for food allergy. The establishment of animal models of food hypersensitivity, which include sensitization by the oral route and anaphylaxis upon oral challenge, have facilitated the investigation of therapies for food allergy. Novel approaches under investigation include the reduction of IgE by the infusion of anti-IgE antibodies, vaccination with plasmid DNA, the use of anti-allergy immunostimulatory sequences, cytokines and bacterial agents, immunotherapy with mutated proteins and peptides, and complementary medicine such as Chinese herbs. SN - 1528-4050 UR - https://www.unboundmedicine.com/medline/citation/12045426/Novel_approaches_for_the_treatment_of_food_allergy_ L2 - http://Insights.ovid.com/pubmed?pmid=12045426 DB - PRIME DP - Unbound Medicine ER -