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Change in saturated fat intake is associated with progression of carotid and femoral intima-media thickness, and with levels of soluble intercellular adhesion molecule-1.
Atherosclerosis 2002; 163(1):113-20A

Abstract

BACKGROUND

A high saturated fat (SFA) intake may stimulate progression of atherosclerosis, and may be positively associated with expression of adhesion molecules.

METHODS

In moderately hypercholesterolaemic participants of a dietary intervention study (n=103; 55+/-10 years), we examined associations between reported changes in SFA intake and changes in carotid and femoral intima-media thickness (IMT) and soluble intercellular adhesion molecule-1 (sICAM-1) levels after 2 years. The carotid and femoral IMT was assessed by high-resolution B-mode ultrasound images.

RESULTS

After 2 years, dietary intake of SFA decreased with 1.8+/-2.6% of energy (P<0.01). In the lowest quintile of change in SFA intake (-5.9+/-1.4% of energy), changes in carotid and femoral IMT were +0.03 mm (SEM 0.03) and -0.09 mm (SEM 0.07), respectively, versus +0.10 mm (SEM 0.03), +0.17 mm (SEM 0.07) in the top quintile (+1.6+/-0.7% of energy) (P linear trend 0.07 (carotis), 0.02 (femoralis)). Changes in sICAM-1 were -19.0 ng/nl (SEM 5.6) in the lowest quintile, versus +8.6 ng/ml (SEM 5.3) in the top quintile (P linear trend <0.001), adjusted for baseline level, SFA intake, body mass index, age, changes in intake of fruit, polyunsaturated fat, and dietary cholesterol. Adjustments for changes in established risk factors did not alter these results.

CONCLUSIONS

Decreased SFA intake may reduce progression of atherosclerosis, as assessed by IMT, and is associated with reduced levels of sICAM-1 after 2 years. Further research using randomised placebo-controlled trials is necessary to exclude potential confounding variables and to confirm causality.

Authors+Show Affiliations

Department of General Practice, University of Groningen, Anton Deusinglaan 4, 9713 AW, Groningen, The Netherlands. w.bemelmans@med.rug.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12048128

Citation

Bemelmans, Wanda J E., et al. "Change in Saturated Fat Intake Is Associated With Progression of Carotid and Femoral Intima-media Thickness, and With Levels of Soluble Intercellular Adhesion Molecule-1." Atherosclerosis, vol. 163, no. 1, 2002, pp. 113-20.
Bemelmans WJ, Lefrandt JD, Feskens EJ, et al. Change in saturated fat intake is associated with progression of carotid and femoral intima-media thickness, and with levels of soluble intercellular adhesion molecule-1. Atherosclerosis. 2002;163(1):113-20.
Bemelmans, W. J., Lefrandt, J. D., Feskens, E. J., Broer, J., Tervaert, J. W., May, J. F., & Smit, A. J. (2002). Change in saturated fat intake is associated with progression of carotid and femoral intima-media thickness, and with levels of soluble intercellular adhesion molecule-1. Atherosclerosis, 163(1), pp. 113-20.
Bemelmans WJ, et al. Change in Saturated Fat Intake Is Associated With Progression of Carotid and Femoral Intima-media Thickness, and With Levels of Soluble Intercellular Adhesion Molecule-1. Atherosclerosis. 2002;163(1):113-20. PubMed PMID: 12048128.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Change in saturated fat intake is associated with progression of carotid and femoral intima-media thickness, and with levels of soluble intercellular adhesion molecule-1. AU - Bemelmans,Wanda J E, AU - Lefrandt,Johan D, AU - Feskens,Edith J M, AU - Broer,Jan, AU - Tervaert,Jan Willem Cohen, AU - May,Johan F, AU - Smit,Andries J, PY - 2002/6/6/pubmed PY - 2002/12/6/medline PY - 2002/6/6/entrez SP - 113 EP - 20 JF - Atherosclerosis JO - Atherosclerosis VL - 163 IS - 1 N2 - BACKGROUND: A high saturated fat (SFA) intake may stimulate progression of atherosclerosis, and may be positively associated with expression of adhesion molecules. METHODS: In moderately hypercholesterolaemic participants of a dietary intervention study (n=103; 55+/-10 years), we examined associations between reported changes in SFA intake and changes in carotid and femoral intima-media thickness (IMT) and soluble intercellular adhesion molecule-1 (sICAM-1) levels after 2 years. The carotid and femoral IMT was assessed by high-resolution B-mode ultrasound images. RESULTS: After 2 years, dietary intake of SFA decreased with 1.8+/-2.6% of energy (P<0.01). In the lowest quintile of change in SFA intake (-5.9+/-1.4% of energy), changes in carotid and femoral IMT were +0.03 mm (SEM 0.03) and -0.09 mm (SEM 0.07), respectively, versus +0.10 mm (SEM 0.03), +0.17 mm (SEM 0.07) in the top quintile (+1.6+/-0.7% of energy) (P linear trend 0.07 (carotis), 0.02 (femoralis)). Changes in sICAM-1 were -19.0 ng/nl (SEM 5.6) in the lowest quintile, versus +8.6 ng/ml (SEM 5.3) in the top quintile (P linear trend <0.001), adjusted for baseline level, SFA intake, body mass index, age, changes in intake of fruit, polyunsaturated fat, and dietary cholesterol. Adjustments for changes in established risk factors did not alter these results. CONCLUSIONS: Decreased SFA intake may reduce progression of atherosclerosis, as assessed by IMT, and is associated with reduced levels of sICAM-1 after 2 years. Further research using randomised placebo-controlled trials is necessary to exclude potential confounding variables and to confirm causality. SN - 0021-9150 UR - https://www.unboundmedicine.com/medline/citation/12048128/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9150(01)00747-X DB - PRIME DP - Unbound Medicine ER -