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Benign breast aspirates: two decades of experience.
Arch Pathol Lab Med. 1996 Nov; 120(11):1056-60.AP

Abstract

OBJECTIVE

To evaluate the reliability of benign breast aspirates.

DESIGN

A 20-year retrospective study of cytologically benign aspirates from palpable breast lesions followed by surgery and review of false negatives.

RESULTS

Data encompassed 1518 benign aspirates followed by benign histology, and 99 by malignant histology. Of the latter, 89% underwent biopsy within 1 month. Review of 52 available false negatives revealed 10 (19%) with no change in the original diagnosis, 16 (31%) reviewed as unsatisfactory specimens, and 26 (50%) reviewed as specimens with focal cytologic atypia (dyshesion, nuclear enlargement, and contour irregularity). Cellularity (>20 epithelial groups per slide) was an important criterion in postmenopausal women.

CONCLUSION

Our study confirms the reliability of benign breast aspirates interpreted in light of clinical and mammographic findings and demonstrates the importance of adequacy evaluation and focal atypia in preventing false negatives.

Authors+Show Affiliations

Department of Pathology, Lankenau Hospital, Wynnewood, PA 19096, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12049109

Citation

Zemba-Palko, V, et al. "Benign Breast Aspirates: Two Decades of Experience." Archives of Pathology & Laboratory Medicine, vol. 120, no. 11, 1996, pp. 1056-60.
Zemba-Palko V, Klenn PJ, Saminathan T, et al. Benign breast aspirates: two decades of experience. Arch Pathol Lab Med. 1996;120(11):1056-60.
Zemba-Palko, V., Klenn, P. J., Saminathan, T., & Kline, T. S. (1996). Benign breast aspirates: two decades of experience. Archives of Pathology & Laboratory Medicine, 120(11), 1056-60.
Zemba-Palko V, et al. Benign Breast Aspirates: Two Decades of Experience. Arch Pathol Lab Med. 1996;120(11):1056-60. PubMed PMID: 12049109.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Benign breast aspirates: two decades of experience. AU - Zemba-Palko,V, AU - Klenn,P J, AU - Saminathan,T, AU - Kline,T S, PY - 1996/11/1/pubmed PY - 2002/7/27/medline PY - 1996/11/1/entrez SP - 1056 EP - 60 JF - Archives of pathology & laboratory medicine JO - Arch Pathol Lab Med VL - 120 IS - 11 N2 - OBJECTIVE: To evaluate the reliability of benign breast aspirates. DESIGN: A 20-year retrospective study of cytologically benign aspirates from palpable breast lesions followed by surgery and review of false negatives. RESULTS: Data encompassed 1518 benign aspirates followed by benign histology, and 99 by malignant histology. Of the latter, 89% underwent biopsy within 1 month. Review of 52 available false negatives revealed 10 (19%) with no change in the original diagnosis, 16 (31%) reviewed as unsatisfactory specimens, and 26 (50%) reviewed as specimens with focal cytologic atypia (dyshesion, nuclear enlargement, and contour irregularity). Cellularity (>20 epithelial groups per slide) was an important criterion in postmenopausal women. CONCLUSION: Our study confirms the reliability of benign breast aspirates interpreted in light of clinical and mammographic findings and demonstrates the importance of adequacy evaluation and focal atypia in preventing false negatives. SN - 0003-9985 UR - https://www.unboundmedicine.com/medline/citation/12049109/Benign_breast_aspirates:_two_decades_of_experience_ L2 - https://medlineplus.gov/breastcancer.html DB - PRIME DP - Unbound Medicine ER -