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The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma.
Arch Ophthalmol 2002; 120(6):714-20; discussion 829-30AO

Abstract

BACKGROUND

The Ocular Hypertension Treatment Study (OHTS) has shown that topical ocular hypotensive medication is effective in delaying or preventing the onset of primary open-angle glaucoma (POAG) in individuals with elevated intraocular pressure (ocular hypertension) and no evidence of glaucomatous damage.

OBJECTIVE

To describe baseline demographic and clinical factors that predict which participants in the OHTS developed POAG.

METHODS

Baseline demographic and clinical data were collected prior to randomization except for corneal thickness measurements, which were performed during follow-up. Proportional hazards models were used to identify factors that predicted which participants in the OHTS developed POAG.

RESULTS

In univariate analyses, baseline factors that predicted the development of POAG included older age, race (African American), sex (male), larger vertical cup-disc ratio, larger horizontal cup-disc ratio, higher intraocular pressure, greater Humphrey visual field pattern standard deviation, heart disease, and thinner central corneal measurement. In multivariate analyses, baseline factors that predicted the development of POAG included older age, larger vertical or horizontal cup-disc ratio, higher intraocular pressure, greater pattern standard deviation, and thinner central corneal measurement.

CONCLUSIONS

Baseline age, vertical and horizontal cup-disc ratio, pattern standard deviation, and intraocular pressure were good predictors for the onset of POAG in the OHTS. Central corneal thickness was found to be a powerful predictor for the development of POAG.

Authors+Show Affiliations

OHTS Coordinating Center, Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, Box 8203, 660 South Euclid, St Louis, MO 63110, USA. mae@vrcc.wustl.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12049575

Citation

Gordon, Mae O., et al. "The Ocular Hypertension Treatment Study: Baseline Factors That Predict the Onset of Primary Open-angle Glaucoma." Archives of Ophthalmology (Chicago, Ill. : 1960), vol. 120, no. 6, 2002, pp. 714-20; discussion 829-30.
Gordon MO, Beiser JA, Brandt JD, et al. The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma. Arch Ophthalmol. 2002;120(6):714-20; discussion 829-30.
Gordon, M. O., Beiser, J. A., Brandt, J. D., Heuer, D. K., Higginbotham, E. J., Johnson, C. A., ... Kass, M. A. (2002). The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma. Archives of Ophthalmology (Chicago, Ill. : 1960), 120(6), pp. 714-20; discussion 829-30.
Gordon MO, et al. The Ocular Hypertension Treatment Study: Baseline Factors That Predict the Onset of Primary Open-angle Glaucoma. Arch Ophthalmol. 2002;120(6):714-20; discussion 829-30. PubMed PMID: 12049575.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma. AU - Gordon,Mae O, AU - Beiser,Julia A, AU - Brandt,James D, AU - Heuer,Dale K, AU - Higginbotham,Eve J, AU - Johnson,Chris A, AU - Keltner,John L, AU - Miller,J Philip, AU - Parrish,Richard K,2nd AU - Wilson,M Roy, AU - Kass,Michael A, PY - 2002/6/7/pubmed PY - 2002/6/18/medline PY - 2002/6/7/entrez SP - 714-20; discussion 829-30 JF - Archives of ophthalmology (Chicago, Ill. : 1960) JO - Arch. Ophthalmol. VL - 120 IS - 6 N2 - BACKGROUND: The Ocular Hypertension Treatment Study (OHTS) has shown that topical ocular hypotensive medication is effective in delaying or preventing the onset of primary open-angle glaucoma (POAG) in individuals with elevated intraocular pressure (ocular hypertension) and no evidence of glaucomatous damage. OBJECTIVE: To describe baseline demographic and clinical factors that predict which participants in the OHTS developed POAG. METHODS: Baseline demographic and clinical data were collected prior to randomization except for corneal thickness measurements, which were performed during follow-up. Proportional hazards models were used to identify factors that predicted which participants in the OHTS developed POAG. RESULTS: In univariate analyses, baseline factors that predicted the development of POAG included older age, race (African American), sex (male), larger vertical cup-disc ratio, larger horizontal cup-disc ratio, higher intraocular pressure, greater Humphrey visual field pattern standard deviation, heart disease, and thinner central corneal measurement. In multivariate analyses, baseline factors that predicted the development of POAG included older age, larger vertical or horizontal cup-disc ratio, higher intraocular pressure, greater pattern standard deviation, and thinner central corneal measurement. CONCLUSIONS: Baseline age, vertical and horizontal cup-disc ratio, pattern standard deviation, and intraocular pressure were good predictors for the onset of POAG in the OHTS. Central corneal thickness was found to be a powerful predictor for the development of POAG. SN - 0003-9950 UR - https://www.unboundmedicine.com/medline/citation/12049575/The_Ocular_Hypertension_Treatment_Study:_baseline_factors_that_predict_the_onset_of_primary_open_angle_glaucoma_ L2 - https://jamanetwork.com/journals/jamaophthalmology/fullarticle/vol/120/pg/714 DB - PRIME DP - Unbound Medicine ER -