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[Biomarkers of tobacco smoke exposure].
Ann Biol Clin (Paris). 2002 May-Jun; 60(3):263-72.AB

Abstract

Tobacco smoking is a major risk factor for cancer, cardiovascular diseases and respiratory illnesses. Smoking is increasing among children and adolescents with subsequent consequences on the health. Furthermore, maternal tobacco smoking during pregnancy adversely affects prenatal growth. Nicotine, the most important tobacco alkaloid, is responsible for maintaining tobacco addiction. According to a recent Circulaire de la direction générale de la santé, nicotine dependence should be determined through questionnaires and quantitative estimate of nicotine metabolites. Nicotine blood level fluctuates and urinary nicotine excretion is of short duration. Nicotine is intensively metabolized in the liver and oxidized into cotinine. Urinary measurement of cotinine appears to be highly related with the degree of intoxication and to allow the differentiation between non exposed and exposed non-smokers. In order to check the present application of nicotine metabolites measurement, a survey was conducted in 340 smoking cessation units. Forty percent physicians (n = 137) answered the survey. For 17% of them, the quantification of nicotine metabolites is included in their daily practise and for 79%, guidelines about cotinine measurement should be given in France. Sixty-seven biologists answered the survey. Recommendations for immunoassay and HPLC determination of cotinine should be given as reported by 66 and 44% of them respectively. Indeed, urinary cotinine measurement with high performance liquid chromatography is highly sensitive and specific. However, immunoassays are more convenient. These two approaches are presently under investigation in order to provide guidelines for optimal use in various clinical situations. Traditional measures for nicotine dependence are the number of cigarettes smoked per day, nicotine intake expressed as mg per day, Fagerstr m questionnaire, expired air carbon monoxide, thiocyanates and cotinine levels in biological fluids. Urinary cotinine measurement is the most useful for the follow-up of smoking cessation including adjustment of nicotine replacement therapy, especially after a clinical event or for the follow-up of smoking pregnant women. It allows the detection of passive smoke exposure in children who are hospitalized for recurrent respiratory illnesses.

Authors+Show Affiliations

Laboratoire de biochimie C (FGC biochimie), Groupe hospitalier Pitié-Salpêtrière, 83, boulevard de l'Hôpital, 75651 Paris cedex 13, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

fre

PubMed ID

12050041

Citation

Berny, C, et al. "[Biomarkers of Tobacco Smoke Exposure]." Annales De Biologie Clinique, vol. 60, no. 3, 2002, pp. 263-72.
Berny C, Boyer JC, Capolaghi B, et al. [Biomarkers of tobacco smoke exposure]. Ann Biol Clin (Paris). 2002;60(3):263-72.
Berny, C., Boyer, J. C., Capolaghi, B., De L'Homme, G., Desch, G., Garelik, D., Hayder, R., Houdret, N., Jacob, N., Koskas, T., Lainé, G., Le Moel, G., Moulsma, M., Plantin-Carrenard, E., & Venembre, P. (2002). [Biomarkers of tobacco smoke exposure]. Annales De Biologie Clinique, 60(3), 263-72.
Berny C, et al. [Biomarkers of Tobacco Smoke Exposure]. Ann Biol Clin (Paris). 2002 May-Jun;60(3):263-72. PubMed PMID: 12050041.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Biomarkers of tobacco smoke exposure]. AU - Berny,C, AU - Boyer,J C, AU - Capolaghi,B, AU - De L'Homme,G, AU - Desch,G, AU - Garelik,D, AU - Hayder,R, AU - Houdret,N, AU - Jacob,N, AU - Koskas,T, AU - Lainé,G, AU - Le Moel,G, AU - Moulsma,M, AU - Plantin-Carrenard,E, AU - Venembre,Ph, PY - 2002/6/7/pubmed PY - 2002/8/1/medline PY - 2002/6/7/entrez SP - 263 EP - 72 JF - Annales de biologie clinique JO - Ann Biol Clin (Paris) VL - 60 IS - 3 N2 - Tobacco smoking is a major risk factor for cancer, cardiovascular diseases and respiratory illnesses. Smoking is increasing among children and adolescents with subsequent consequences on the health. Furthermore, maternal tobacco smoking during pregnancy adversely affects prenatal growth. Nicotine, the most important tobacco alkaloid, is responsible for maintaining tobacco addiction. According to a recent Circulaire de la direction générale de la santé, nicotine dependence should be determined through questionnaires and quantitative estimate of nicotine metabolites. Nicotine blood level fluctuates and urinary nicotine excretion is of short duration. Nicotine is intensively metabolized in the liver and oxidized into cotinine. Urinary measurement of cotinine appears to be highly related with the degree of intoxication and to allow the differentiation between non exposed and exposed non-smokers. In order to check the present application of nicotine metabolites measurement, a survey was conducted in 340 smoking cessation units. Forty percent physicians (n = 137) answered the survey. For 17% of them, the quantification of nicotine metabolites is included in their daily practise and for 79%, guidelines about cotinine measurement should be given in France. Sixty-seven biologists answered the survey. Recommendations for immunoassay and HPLC determination of cotinine should be given as reported by 66 and 44% of them respectively. Indeed, urinary cotinine measurement with high performance liquid chromatography is highly sensitive and specific. However, immunoassays are more convenient. These two approaches are presently under investigation in order to provide guidelines for optimal use in various clinical situations. Traditional measures for nicotine dependence are the number of cigarettes smoked per day, nicotine intake expressed as mg per day, Fagerstr m questionnaire, expired air carbon monoxide, thiocyanates and cotinine levels in biological fluids. Urinary cotinine measurement is the most useful for the follow-up of smoking cessation including adjustment of nicotine replacement therapy, especially after a clinical event or for the follow-up of smoking pregnant women. It allows the detection of passive smoke exposure in children who are hospitalized for recurrent respiratory illnesses. SN - 0003-3898 UR - https://www.unboundmedicine.com/medline/citation/12050041/[Biomarkers_of_tobacco_smoke_exposure]_ L2 - http://www.jle.com/medline.md?issn=0003-3898&vol=60&iss=3&page=263 DB - PRIME DP - Unbound Medicine ER -