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CB(1) and CB(2) receptor-mediated signalling: a focus on endocannabinoids.
Prostaglandins Leukot Essent Fatty Acids. 2002 Feb-Mar; 66(2-3):161-71.PL

Abstract

The discovery that the major psychoactive component of marijuana activated two G-protein coupled receptors prompted the search for the endogenous cannabinoid ligands now termed endocannabinoids. To date three putative ligands have been isolated, all consisting of arachidonic acid linked to a polar head group. Both synthetic and endogenous cannabinoids have been the focus of extensive study over the past few years. The signalling events produced by endocannabinoids as compared with Delta(9) -THC and synthetic cannabinoids contain many similarities. However, as research focuses more on endogenous ligands the divergence between these classes of compounds grows. This review focuses upon the developments in endocannabinoid signal transduction from receptor-mediated activation of common G-protein linked effector pathways through downstream regulation of gene transcription.

Authors+Show Affiliations

Forbes Norris ALS Research Center, California Pacific Medical Centre, 2351 Clay Street, Suite 416, San Francisco, CA 94115, USA.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

12052033

Citation

McAllister, Sean D., and Michelle Glass. "CB(1) and CB(2) Receptor-mediated Signalling: a Focus On Endocannabinoids." Prostaglandins, Leukotrienes, and Essential Fatty Acids, vol. 66, no. 2-3, 2002, pp. 161-71.
McAllister SD, Glass M. CB(1) and CB(2) receptor-mediated signalling: a focus on endocannabinoids. Prostaglandins Leukot Essent Fatty Acids. 2002;66(2-3):161-71.
McAllister, S. D., & Glass, M. (2002). CB(1) and CB(2) receptor-mediated signalling: a focus on endocannabinoids. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 66(2-3), 161-71.
McAllister SD, Glass M. CB(1) and CB(2) Receptor-mediated Signalling: a Focus On Endocannabinoids. Prostaglandins Leukot Essent Fatty Acids. 2002 Feb-Mar;66(2-3):161-71. PubMed PMID: 12052033.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - CB(1) and CB(2) receptor-mediated signalling: a focus on endocannabinoids. AU - McAllister,Sean D, AU - Glass,Michelle, PY - 2002/6/8/pubmed PY - 2002/12/7/medline PY - 2002/6/8/entrez SP - 161 EP - 71 JF - Prostaglandins, leukotrienes, and essential fatty acids JO - Prostaglandins Leukot. Essent. Fatty Acids VL - 66 IS - 2-3 N2 - The discovery that the major psychoactive component of marijuana activated two G-protein coupled receptors prompted the search for the endogenous cannabinoid ligands now termed endocannabinoids. To date three putative ligands have been isolated, all consisting of arachidonic acid linked to a polar head group. Both synthetic and endogenous cannabinoids have been the focus of extensive study over the past few years. The signalling events produced by endocannabinoids as compared with Delta(9) -THC and synthetic cannabinoids contain many similarities. However, as research focuses more on endogenous ligands the divergence between these classes of compounds grows. This review focuses upon the developments in endocannabinoid signal transduction from receptor-mediated activation of common G-protein linked effector pathways through downstream regulation of gene transcription. SN - 0952-3278 UR - https://www.unboundmedicine.com/medline/citation/12052033/CB_1__and_CB_2__receptor_mediated_signalling:_a_focus_on_endocannabinoids_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0952327801903448 DB - PRIME DP - Unbound Medicine ER -