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Endocannabinoids in pain modulation.
Prostaglandins Leukot Essent Fatty Acids. 2002 Feb-Mar; 66(2-3):235-42.PL

Abstract

Five major approaches have been employed to determine the role of endocannabinoids in pain modulation: (1) studies of various markers of endocannabinoid action aimed at determining whether the necessary cannabinoid biochemical machinery is present in those brain areas that control pain sensitivity; (2) administration of exogenous cannabinoids to determine whether endocannabinoid action at appropriate sites would lead to a loss of pain sensitivity; (3) administration of compounds that would affect endocannabinoid action such as antagonists and transport inhibitors to determine whether drug-induced preterbation of cannabinoid action would alter pain sensitivity; (4) studies of genetically altered animals aimed at determining whether pain responses or responses to cannabinergic drugs are altered; and (5) studies that measure the release of endocannabinoids. Converging evidence from each of these research areas indicates that endocannabinods function to control pain in parallel with endogenous opioids but via different mechanisms.

Authors+Show Affiliations

Department of Psychology, Brown University, 89 Waterman Street, Providence, RI 02912, USA. j.walker@brown.eduNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

12052039

Citation

Walker, J M., and S M. Huang. "Endocannabinoids in Pain Modulation." Prostaglandins, Leukotrienes, and Essential Fatty Acids, vol. 66, no. 2-3, 2002, pp. 235-42.
Walker JM, Huang SM. Endocannabinoids in pain modulation. Prostaglandins Leukot Essent Fatty Acids. 2002;66(2-3):235-42.
Walker, J. M., & Huang, S. M. (2002). Endocannabinoids in pain modulation. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 66(2-3), 235-42.
Walker JM, Huang SM. Endocannabinoids in Pain Modulation. Prostaglandins Leukot Essent Fatty Acids. 2002 Feb-Mar;66(2-3):235-42. PubMed PMID: 12052039.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Endocannabinoids in pain modulation. AU - Walker,J M, AU - Huang,S M, PY - 2002/6/8/pubmed PY - 2002/12/7/medline PY - 2002/6/8/entrez SP - 235 EP - 42 JF - Prostaglandins, leukotrienes, and essential fatty acids JO - Prostaglandins Leukot. Essent. Fatty Acids VL - 66 IS - 2-3 N2 - Five major approaches have been employed to determine the role of endocannabinoids in pain modulation: (1) studies of various markers of endocannabinoid action aimed at determining whether the necessary cannabinoid biochemical machinery is present in those brain areas that control pain sensitivity; (2) administration of exogenous cannabinoids to determine whether endocannabinoid action at appropriate sites would lead to a loss of pain sensitivity; (3) administration of compounds that would affect endocannabinoid action such as antagonists and transport inhibitors to determine whether drug-induced preterbation of cannabinoid action would alter pain sensitivity; (4) studies of genetically altered animals aimed at determining whether pain responses or responses to cannabinergic drugs are altered; and (5) studies that measure the release of endocannabinoids. Converging evidence from each of these research areas indicates that endocannabinods function to control pain in parallel with endogenous opioids but via different mechanisms. SN - 0952-3278 UR - https://www.unboundmedicine.com/medline/citation/12052039/Endocannabinoids_in_pain_modulation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0952327801903618 DB - PRIME DP - Unbound Medicine ER -