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Endocannabinoids and the gut.
Prostaglandins Leukot Essent Fatty Acids. 2002 Feb-Mar; 66(2-3):333-41.PL

Abstract

In the digestive tract, there is evidence for the presence of high amounts of endocannabinoids (anandamide and 2-arachidonylglycerol) and of mechanisms for endocannabinoid metabolism and possibly endocannabinoid uptake. Pharmacological studies have shown that anandamide inhibits excitatory transmission and peristalsis in the isolated guinea-pig ileum and reduces intestinal motility in the mouse in vivo; all these effects are mediated by CB(1) receptors, which are located on enteric nerves. Conversely, the selective CB(1) receptor antagonist SR141716A increased intestinal motility and this effect is likely due to the displacement of endocannabinoids rather than to its inverse agonist properties. Interestingly, inhibitory effects of anandamide via non-CB(1) receptors and stimulatory effects via vanilloid receptors have also been proposed.

Authors+Show Affiliations

Department of Experimental Pharmacology, University of Naples Federico II, via D. Montesano 49, 80131 Naples, Italy.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

12052047

Citation

Pinto, L, et al. "Endocannabinoids and the Gut." Prostaglandins, Leukotrienes, and Essential Fatty Acids, vol. 66, no. 2-3, 2002, pp. 333-41.
Pinto L, Capasso R, Di Carlo G, et al. Endocannabinoids and the gut. Prostaglandins Leukot Essent Fatty Acids. 2002;66(2-3):333-41.
Pinto, L., Capasso, R., Di Carlo, G., & Izzo, A. A. (2002). Endocannabinoids and the gut. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 66(2-3), 333-41.
Pinto L, et al. Endocannabinoids and the Gut. Prostaglandins Leukot Essent Fatty Acids. 2002 Feb-Mar;66(2-3):333-41. PubMed PMID: 12052047.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Endocannabinoids and the gut. AU - Pinto,L, AU - Capasso,R, AU - Di Carlo,G, AU - Izzo,A A, PY - 2002/6/8/pubmed PY - 2002/12/7/medline PY - 2002/6/8/entrez SP - 333 EP - 41 JF - Prostaglandins, leukotrienes, and essential fatty acids JO - Prostaglandins Leukot. Essent. Fatty Acids VL - 66 IS - 2-3 N2 - In the digestive tract, there is evidence for the presence of high amounts of endocannabinoids (anandamide and 2-arachidonylglycerol) and of mechanisms for endocannabinoid metabolism and possibly endocannabinoid uptake. Pharmacological studies have shown that anandamide inhibits excitatory transmission and peristalsis in the isolated guinea-pig ileum and reduces intestinal motility in the mouse in vivo; all these effects are mediated by CB(1) receptors, which are located on enteric nerves. Conversely, the selective CB(1) receptor antagonist SR141716A increased intestinal motility and this effect is likely due to the displacement of endocannabinoids rather than to its inverse agonist properties. Interestingly, inhibitory effects of anandamide via non-CB(1) receptors and stimulatory effects via vanilloid receptors have also been proposed. SN - 0952-3278 UR - https://www.unboundmedicine.com/medline/citation/12052047/Endocannabinoids_and_the_gut_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S095232780190345X DB - PRIME DP - Unbound Medicine ER -