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Effect of ozagrel hydrochloride, a thromboxane synthetase inhibitor, on alcoholic beverage-induced bronchoconstriction in asthmatic patients.
Prostaglandins Leukot Essent Fatty Acids 2002; 66(4):397-401PL

Abstract

Acetaldehyde is thought to be a main factor of alcohol-induced asthma. The thromboxane (TX) synthetase inhibitor, ozagrel hydrochloride, inhibits acetaldehyde-induced bronchoconstriction in asthmatic patients. The present study evaluated the involvement of TXA(2) on alcoholic beverage-induced bronchoconstriction. Four patients with alcohol-induced asthma received ozagrel (400 mg for 4 days) or placebo using a single-blind, randomized, cross-over design. On two separate study days, each subject drank the same brand and volume of alcoholic beverage (beer or Japanese sake) and bronchoconstriction was assessed as the change in peak expiratory flow (PEF). The effect of ozagrel on the aerosolized challenge of acetaldehyde was investigated in the same subjects. Although aerosolized acetaldehyde-induced bronchoconstriction was significantly prevented by ozagrel, there were no differences in the time course of the decrease in PEF or the maximum fall in PEF after alcohol intake between placebo and ozagrel. We conclude that TXA(2) is not involved in alcoholic beverage-induced bronchoconstriction.

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  • Publisher Full Text

    • Authors+Show Affiliations

    Myou S
    The Third Department of Internal Medicine, Kanazawa University School of Medicine, Japan. myous@nifty.com
    Fujimura M
    No affiliation info available
    Nishi K
    No affiliation info available
    Kita T
    No affiliation info available
    Kurashima K
    No affiliation info available
    Tachibana H
    No affiliation info available
    Ishiura Y
    No affiliation info available
    Nakao S
    No affiliation info available

    MeSH

    AcetaldehydeAdultAlcoholic BeveragesAsthmaBeerBronchial Provocation TestsBronchoconstrictionHumansMaleMethacrylatesMiddle AgedPeak Expiratory Flow RateSample SizeThromboxane-A SynthaseWine

    Pub Type(s)

    Clinical Trial
    Journal Article
    Randomized Controlled Trial

    Language

    eng

    PubMed ID

    12054909

    Citation

    Myou, Shigeharu, et al. "Effect of Ozagrel Hydrochloride, a Thromboxane Synthetase Inhibitor, On Alcoholic Beverage-induced Bronchoconstriction in Asthmatic Patients." Prostaglandins, Leukotrienes, and Essential Fatty Acids, vol. 66, no. 4, 2002, pp. 397-401.
    Myou S, Fujimura M, Nishi K, et al. Effect of ozagrel hydrochloride, a thromboxane synthetase inhibitor, on alcoholic beverage-induced bronchoconstriction in asthmatic patients. Prostaglandins Leukot Essent Fatty Acids. 2002;66(4):397-401.
    Myou, S., Fujimura, M., Nishi, K., Kita, T., Kurashima, K., Tachibana, H., ... Nakao, S. (2002). Effect of ozagrel hydrochloride, a thromboxane synthetase inhibitor, on alcoholic beverage-induced bronchoconstriction in asthmatic patients. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 66(4), pp. 397-401.
    Myou S, et al. Effect of Ozagrel Hydrochloride, a Thromboxane Synthetase Inhibitor, On Alcoholic Beverage-induced Bronchoconstriction in Asthmatic Patients. Prostaglandins Leukot Essent Fatty Acids. 2002;66(4):397-401. PubMed PMID: 12054909.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effect of ozagrel hydrochloride, a thromboxane synthetase inhibitor, on alcoholic beverage-induced bronchoconstriction in asthmatic patients. AU - Myou,Shigeharu, AU - Fujimura,Masaki, AU - Nishi,Kohichi, AU - Kita,Toshiyuki, AU - Kurashima,Kazuyoshi, AU - Tachibana,Hideki, AU - Ishiura,Yoshihisa, AU - Nakao,Shinji, PY - 2002/6/11/pubmed PY - 2003/1/10/medline PY - 2002/6/11/entrez SP - 397 EP - 401 JF - Prostaglandins, leukotrienes, and essential fatty acids JO - Prostaglandins Leukot. Essent. Fatty Acids VL - 66 IS - 4 N2 - Acetaldehyde is thought to be a main factor of alcohol-induced asthma. The thromboxane (TX) synthetase inhibitor, ozagrel hydrochloride, inhibits acetaldehyde-induced bronchoconstriction in asthmatic patients. The present study evaluated the involvement of TXA(2) on alcoholic beverage-induced bronchoconstriction. Four patients with alcohol-induced asthma received ozagrel (400 mg for 4 days) or placebo using a single-blind, randomized, cross-over design. On two separate study days, each subject drank the same brand and volume of alcoholic beverage (beer or Japanese sake) and bronchoconstriction was assessed as the change in peak expiratory flow (PEF). The effect of ozagrel on the aerosolized challenge of acetaldehyde was investigated in the same subjects. Although aerosolized acetaldehyde-induced bronchoconstriction was significantly prevented by ozagrel, there were no differences in the time course of the decrease in PEF or the maximum fall in PEF after alcohol intake between placebo and ozagrel. We conclude that TXA(2) is not involved in alcoholic beverage-induced bronchoconstriction. SN - 0952-3278 UR - https://www.unboundmedicine.com/medline/citation/12054909/Effect_of_ozagrel_hydrochloride_a_thromboxane_synthetase_inhibitor_on_alcoholic_beverage_induced_bronchoconstriction_in_asthmatic_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0952327802903650 DB - PRIME DP - Unbound Medicine ER -