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Combining behavioral and pharmacological treatments for obesity.
Obes Res 2002; 10(6):560-74OR

Abstract

Weight-loss medications are currently recommended for use only as an adjunct to diet, exercise, and behavior modification. Little, however, is known about the benefits of combining behavioral and pharmacological therapies or about the mechanisms that would make these combined approaches more effective than either used alone. This article reviews the effects of adding pharmacotherapy (i.e., principally sibutramine and orlistat) to a modest program of lifestyle modification. Studies revealed that the addition of medication typically improved short- and long-term weight loss compared with lifestyle modification alone. The best results, however, were obtained when medications were combined with an intensive, group program of lifestyle modification. The two approaches may have additive effects; behavioral treatment seems to help obese individuals control the external (i.e., food-related) environment, whereas pharmacotherapy may control the internal environment by reducing hunger, cravings, or nutrient absorption. The article examines possible methods of sequencing behavioral and pharmacological therapies and offers suggestions for future research.

Authors+Show Affiliations

University of Pennsylvania School of Medicine, Philadelphia, USA. sphelan@lifespan.orgNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

12055334

Citation

Phelan, Suzanne, and Thomas A. Wadden. "Combining Behavioral and Pharmacological Treatments for Obesity." Obesity Research, vol. 10, no. 6, 2002, pp. 560-74.
Phelan S, Wadden TA. Combining behavioral and pharmacological treatments for obesity. Obes Res. 2002;10(6):560-74.
Phelan, S., & Wadden, T. A. (2002). Combining behavioral and pharmacological treatments for obesity. Obesity Research, 10(6), pp. 560-74.
Phelan S, Wadden TA. Combining Behavioral and Pharmacological Treatments for Obesity. Obes Res. 2002;10(6):560-74. PubMed PMID: 12055334.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combining behavioral and pharmacological treatments for obesity. AU - Phelan,Suzanne, AU - Wadden,Thomas A, PY - 2002/6/11/pubmed PY - 2002/11/26/medline PY - 2002/6/11/entrez SP - 560 EP - 74 JF - Obesity research JO - Obes. Res. VL - 10 IS - 6 N2 - Weight-loss medications are currently recommended for use only as an adjunct to diet, exercise, and behavior modification. Little, however, is known about the benefits of combining behavioral and pharmacological therapies or about the mechanisms that would make these combined approaches more effective than either used alone. This article reviews the effects of adding pharmacotherapy (i.e., principally sibutramine and orlistat) to a modest program of lifestyle modification. Studies revealed that the addition of medication typically improved short- and long-term weight loss compared with lifestyle modification alone. The best results, however, were obtained when medications were combined with an intensive, group program of lifestyle modification. The two approaches may have additive effects; behavioral treatment seems to help obese individuals control the external (i.e., food-related) environment, whereas pharmacotherapy may control the internal environment by reducing hunger, cravings, or nutrient absorption. The article examines possible methods of sequencing behavioral and pharmacological therapies and offers suggestions for future research. SN - 1071-7323 UR - https://www.unboundmedicine.com/medline/citation/12055334/Combining_behavioral_and_pharmacological_treatments_for_obesity_ L2 - https://doi.org/10.1038/oby.2002.77 DB - PRIME DP - Unbound Medicine ER -