Tags

Type your tag names separated by a space and hit enter

Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP.
Nat Immunol. 2002 Jul; 3(7):673-80.NI

Abstract

Whether epithelial cells play a role in triggering the immune cascade leading to T helper 2 (T(H)2)-type allergic inflammation is not known. We show here that human thymic stromal lymphopoietin (TSLP) potently activated CD11c(+) dendritic cells (DCs) and induced production of the T(H)2-attracting chemokines TARC (thymus and activation-regulated chemokine; also known as CCL17) and MDC (macrophage-derived chemokine; CCL22). TSLP-activated DCs primed naïve T(H) cells to produce the proallergic cytokines interleukin 4 (IL-4), IL-5, IL-13 and tumor necrosis factor-alpha, while down-regulating IL-10 and interferon-gamma. TSLP was highly expressed by epithelial cells, especially keratinocytes from patients with atopic dermatitis. TSLP expression was associated with Langerhans cell migration and activation in situ. These findings shed new light on the function of human TSLP and the role played by epithelial cells and DCs in initiating allergic inflammation.

Authors+Show Affiliations

DNAX, 901 California Avenue, Palo Alto, CA 94304, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12055625

Citation

Soumelis, Vassili, et al. "Human Epithelial Cells Trigger Dendritic Cell Mediated Allergic Inflammation By Producing TSLP." Nature Immunology, vol. 3, no. 7, 2002, pp. 673-80.
Soumelis V, Reche PA, Kanzler H, et al. Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP. Nat Immunol. 2002;3(7):673-80.
Soumelis, V., Reche, P. A., Kanzler, H., Yuan, W., Edward, G., Homey, B., Gilliet, M., Ho, S., Antonenko, S., Lauerma, A., Smith, K., Gorman, D., Zurawski, S., Abrams, J., Menon, S., McClanahan, T., de Waal-Malefyt Rd, R., Bazan, F., Kastelein, R. A., & Liu, Y. J. (2002). Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP. Nature Immunology, 3(7), 673-80.
Soumelis V, et al. Human Epithelial Cells Trigger Dendritic Cell Mediated Allergic Inflammation By Producing TSLP. Nat Immunol. 2002;3(7):673-80. PubMed PMID: 12055625.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP. AU - Soumelis,Vassili, AU - Reche,Pedro A, AU - Kanzler,Holger, AU - Yuan,Wei, AU - Edward,Gina, AU - Homey,Bernhart, AU - Gilliet,Michel, AU - Ho,Steve, AU - Antonenko,Svetlana, AU - Lauerma,Annti, AU - Smith,Kathleen, AU - Gorman,Daniel, AU - Zurawski,Sandra, AU - Abrams,Jon, AU - Menon,Satish, AU - McClanahan,Terri, AU - de Waal-Malefyt Rd,Rene, AU - Bazan,Fernando, AU - Kastelein,Robert A, AU - Liu,Yong-Jun, Y1 - 2002/06/10/ PY - 2002/6/11/pubmed PY - 2002/7/31/medline PY - 2002/6/11/entrez SP - 673 EP - 80 JF - Nature immunology JO - Nat. Immunol. VL - 3 IS - 7 N2 - Whether epithelial cells play a role in triggering the immune cascade leading to T helper 2 (T(H)2)-type allergic inflammation is not known. We show here that human thymic stromal lymphopoietin (TSLP) potently activated CD11c(+) dendritic cells (DCs) and induced production of the T(H)2-attracting chemokines TARC (thymus and activation-regulated chemokine; also known as CCL17) and MDC (macrophage-derived chemokine; CCL22). TSLP-activated DCs primed naïve T(H) cells to produce the proallergic cytokines interleukin 4 (IL-4), IL-5, IL-13 and tumor necrosis factor-alpha, while down-regulating IL-10 and interferon-gamma. TSLP was highly expressed by epithelial cells, especially keratinocytes from patients with atopic dermatitis. TSLP expression was associated with Langerhans cell migration and activation in situ. These findings shed new light on the function of human TSLP and the role played by epithelial cells and DCs in initiating allergic inflammation. SN - 1529-2908 UR - https://www.unboundmedicine.com/medline/citation/12055625/Human_epithelial_cells_trigger_dendritic_cell_mediated_allergic_inflammation_by_producing_TSLP_ L2 - http://dx.doi.org/10.1038/ni805 DB - PRIME DP - Unbound Medicine ER -